Biology of Extracellular Molecular Chaperones

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: Péter Csermely.

• Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5–7 June 2007. Editors: Derek J. Chadwick (Organizer) and Jamie Goode.This symposium is based on a proposal made by Brian Henderson, R. John Ellis and A. Graham PockleyPéter Csermely Chair's introduction.Jodie Haak and Kevin C. Kregel 1962–2007: a cell stress odyssey.Discussion.Peter A. Lund and R. John Ellis The chaperone function: meanings and myths.Discussion.Péter Csermely, Tamás Korcsmáros, István A. Kovács, Máté S. Szalay and Csaba Soti Systems biology of molecular chaperone networks.Discussion.Radhey S. Gupta , Nallur B. Ramachandra, Timothy Bowes and Bhag Singh Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10.Discussion.Martha Triantafilou, Daniel Sawyer, Abdiaziz Nor, Emmanouil Vakakis and Kathy Triantafilou Cell surface molecular chaperones as endogenous modulators of the innate immune response.Discussion.A. Graham Pockley and Gabriele Multhoff Cell stress proteins in extracellular fluids: friend or foe?Discussion.Francisco J. Quintana and Irun R. Cohen HSP60 speaks to the immune system in many voices.Discussion.Stuart K. Calderwood, Jianlin Gong, Jimmy R. Theriault, Salamatu S. Mambula and Philip J. Gray Jnr Cell stress proteins: novel immunotherapeutics.Discussion.General discussion.Brian Henderson Cell stress proteins as modulators of bacteria–host interactions.Discussion.Anthony R. M. Coates, Ana Cehovin and Yanmin Hu Chaperonin 60 and macrophage activation.Discussion.Alexzander Asea Hsp70: a chaperokine.Discussion.Hajime Nakamura Extracellular functions of thioredoxin.Discussion.Carol L. Miller-Graziano, Asit De, Krzysztof Laudanski, Tara Herrmann and Sanjukta Bandyopadhyay HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function.Discussion.Gabriel S. Panayi and Valerie M. Corrigall BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis.Discussion.Final discussion.Index of contributors.Subject index.

"This is a useful addition to the literature on chaperones … .It provides an excellent source of information for anyone who needs more than just basic knowledge about this area of biology." (Doodys Book Reviews, December 2008)