Inflammatory Bowel Disease

Derek J. Chadwick and Jamie A. Goode are editors for Inflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune Systems and other scientific titles.

• Symposium on Inflammatory bowel disease-crossroads of microbes, epithelium and immune systems, held at the Novartis Foundation, London, 25 - 27 November 2003Editors: Derek Chadwick (Organizer) and Jamie GoodeThis symposium is based on a proposal made by Derek Jewell and Bill RoedigerDerek Jewell Chair's introduction 1John D. Rioux Progress towards identifying inflammatory bowel disease susceptibility genes 3Discussion 11T. Ahmad Phenotype-determining genes in inflammatory bowel disease 17Discussion 29Dermot Kelleher, Richard Farrell and Ross McManus Pharmacogenetics of inflammatory bowel disease 41Discussion 53G.T. Macfarlane, E. Furrie and S. Macfarlane Bacterial milieu and mucosal bacteria in ulcerative colitis 57Discussion 64Y. R. Mahida and R. N. Cunliffe Defensins and mucosal protection 71Discussion 77W. E.W. Roediger Intestinal mycoplasma in Crohn's disease 85Discussion 93John H. Cummings and San Choon Kong Probiotics, prebiotics and antibiotics in inflammatory bowel disease 99Discussion 112Andrei I. Ivanov, Asma Nusrat and Charles A. Parkos The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption 115Discussion 124Peter R. Gibson Apoptosis or necrosis ö colonic epithelial cell survival 133Discussion 145Ken Takeuchi, Laurence Maiden and Ingvar Bjarnason Genetic aspects of intestinal permeability in inflammatory bowel disease 151Discussion 159Fiona Powrie and Holm Uhlig Animal models of intestinal inflammation: clues to the pathogenesis of inflammatory bowel disease 164Discussion 174Holm H. Uhlig, Christian Mottet and Fiona Powrie Homing of intestinal immune cells 179Discussion 188S. Ghosh Anti-TNF therapy in Crohn's disease 193Discussion 205Final discussion 211Index of contributors 219Subject index 221

"This is a well written book that provides a succinct, easy to read summary of the current concepts in IBD. The discussions following each chapter are invaluable." (Doody's Book Review Service)