Del 283 - Novartis Foundation Symposia

Vascular Development

Inbunden, Engelska, 2007

AvDerek J. Chadwick,Jamie A. Goode,Derek J Chadwick,Jamie A Goode

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The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups.The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues.The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation.While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues.With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Produktinformation

Utgivningsdatum2007-07-20
Mått158 x 235 x 17 mm
Vikt544 g
FormatInbunden
SpråkEngelska
SerieNovartis Foundation Symposia
Antal sidor260
FörlagJohn Wiley & Sons Inc
ISBN9780470034286

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Christer Betsholtz Chair’s introduction 1Maria Grazia Lampugnani and Elisabetta Dejana The control of endothelial cell functions by adherens junctions 4Discussion 13Maike Schmidt, Ann De Mazière, Tanya Smyczek, Alane Gray, Leon Parker, Ellen Filvaroff, Dorothy French, Suzanne van Dijk, Judith Klumperman and Weilan Ye The role of Egfl 7 in vascular morphogenesis 18Discussion 28Max Levin, Andrew J. Ewald, Martin McMahon, Zena Werb and Keith Mostov A model of intussusceptive angiogenesis 37Discussion 42Tomáš Kucera, Jan Eglinger, Boris Strilic and Eckhard LammertVascular lumen formation from a cell biological perspective 46Discussion 56Christopher J. Drake, Paul A. Fleming and W. Scott ArgravesThe genetics of vasculogenesis 61Discussion 71Steven Suchting, Catarina Freitas, Ferdinand le Noble, Rui Benedito, Christiane Bréant, Antonio Duarte and Anne Eichmann Negative regulators of vessel patterning 77Discussion 80Taija Mäkinen and Kari Alitalo Lymphangiogenesis in development and disease 87Discussion 98Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos and Gavin Thurston Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis 106Discussion 121Georg Breier, Alexander H. Licht, Anke Nicolaus, Anne Klotzsche, Ben Wielockx and Zuzana Kirsnerova HIF in vascular development and tumour angiogenesis 126Discussion 133Karina Yaniv, Sumio Isogai, Daniel Castranova, Louis Dye, Jiro Hitomi and Brant M. Weinstein Imaging the developing lymphatic system using the zebrafish 139Discussion 148Frances High and Jonathan A. Epstein Signalling pathways regulating cardiac neural crest migration and differentiation 152Discussion 161Ralf H. Adams Investigation of the angiogenic programme with tissue-specific and inducible genetic approaches in mice 165Discussion 171Gary K. Owens Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity 174Discussion 191Andrea Lundkvist, Sunyoung Lee, Luisa Iruela-Arispe, Christer Betsholtz and Holger Gerhardt Growth factor gradients in vascular patterning 194Discussion 201Deborah A. Freedman, Yasushige Kashima and Kenneth S. ZaretEndothelial cell promotion of early liver and pancreas development 207Discussion 216Jörg Wilting, Kerstin Buttler, Jochen Rössler, Susanne Norgall, Lothar Schweigerer, Herbert A. Weich and Maria PapoutsiEmbryonic development and malformation of lymphatic vessels 220Discussion 227Joaquim Miguel Vieira, Quenten Schwarz and Christiana RuhrbergRole of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse 230Discussion 235Final discussion 238Tracheal tube development in Drosophila 238Closing remarks 240Contributor index 242Subject index 244