Tumor Microenvironment

Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals, including Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

• 1.   The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control.- 2.     Dormancy in the Tumor Microenvironment.- 3.    Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy.- 4.    Studying the tumor microenvironment in zebrafish.- 5. Pre-metastatic niche formation by neutrophils in different organs.- 6.  Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors.- 7.  The dog as a model to study the tumor microenvironment.- 8.  EFFEROCYTOSIS AND THE STORY OF “FIND ME’’, ‘’EAT ME” AND “DON’T EAT ME” SIGNALING IN THE TUMOR MICRO ENVIRONMENT.- 9.  Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models.- 10.  Mitochondria and the tumor microenvironment in blood cancer.- 11. Telocytes in the tumor microenvironment.- 12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment.- 13.  Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer.- 14.  Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer.- 15.  The adrenergic nerve network in cancer.- 16.  Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer.- 17.Brain metastases and tumor microenvironment.- 18.  MIGRATION STIMULATING FACTOR (MSF).  ITS ROLE IN THE TUMOUR.- MICROENVIRONMENT.- 19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer.- 20.  Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression.- 21.  Progesterone receptor signaling in the breast tumor microenvironment.- 22.  Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen.- 23.  Sex-based differences in the tumor microenvironmet.