Recent Advances in iPSC Technology

Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

• 1. Modeling the Cardiovascular Toxicities of Anticancer Therapies in the Era of Precision Medicine2. Looking at Induced Pluripotent Stem Cell (iPSCs) Differentiation Through the Lens of The Non-Coding Genome3. In Vitro Blood-Brain Barrier Model Derived from Human Ips Cells and Its Applications4. The Progress in The Study of Reprogramming to Acquire the Features of Stem Cells In iPSCs and Cancers5. An Introduction to The Mathematical Modelling of iPSCs6. Use of iPSCs-Derived Brain Organoids to Study Human Brain Evolution7. Self-Renewal in Induced Pluripotent Stem Cells8. Strategies for iPSCs Expansion9. An Overview of Reprogramming Approaches to Derive Integration-Free Induced Pluripotent Stem Cells for Prospective Biomedical Applications10. Induced Pluripotent Stem Cells Versus Embryonic Stem Cells: A Comprehensive Overview of Differences and Similarities

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