Principles of Molecular Medicine

• Genetics.- Mendelian Inheritance.- Nontraditional Inheritance.- Identifying Causal Genetic Factors.- Cancer Genetics and Molecular Oncology.- Pharmacogenetics.- Hemophilia as a Model Disease for Gene Therapy of Genetic Disorders.- Genetic Counseling.- Animal Models in Biomedical Research.- Ethical, Legal, and Social Implications.- Cardiology.- Congenital Heart Disease.- Inherited Cardiomyopathies.- Heart Failure.- Aortic Diseases.- Atherosclerotic Coronary Disease.- Lipid Metabolism and Coronary Artery Disease.- Hypertension.- Cardiac Hypertrophy.- Arrhythmias.- Genomics.- Cardiovascular Gene Therapy.- Pulmonary Diseases.- Idiopathic Interstitial Pneumonias.- Asthma.- Pulmonary Emphysema.- Pulmonary Hypertension.- Acute Lung Injury.- Primary Ciliary Dyskinesia.- Cystic Fibrosis.- Gene Therapy for Lung Diseases.- Sarcoidosis.- Disorders of Pulmonary Surfactant Homeostasis.- Endocrinology.- Mechanisms of Hormone Action.- Diabetes Mellitus.- Pituitary Function and Neoplasia.- Growth Hormone Deficiency Disorders.- Thyroid Disorders.- Disorders of the Parathyroid Gland.- Congenital Adrenal Hyperplasia.- Adrenal Diseases.- Multiple Endocrine Neoplasia Type 1.- Multiple Endocrine Neoplasia Type 2.- Disorders of Sex Determination and Differentiation.- Sex Chromosome Disorders.- Disorders of Pubertal Development.- Defects of Androgen Action.- Molecular Endocrinology of the Testis.- Ovarian Diseases.- Metabolic Disorders.- Gastrointestinal Regulation of Food Intake.- Cellular Regulation of Lipolysis.- Fat-Induced Insulin Resistance and Atherosclerosis.- Metabolic and Molecular Aspects of Sarcopenia.- Adipose Tissue Development and Metabolism.- Gastroenterology.- Hepatitis C.- Molecular Diagnostics in Hepatitis B.- Hereditary Hemochromatosis.- Pancreatic Exocrine Dysfunction.- Small and Large Bowel Dysfunction.- The Molecular Mechanisms of Helicobacter pylori-Associated Gastroduodenal Disease.- Nephrology.- Nitric Oxide Synthase and Cyclooxygenase in the Kidneys.- Hypertensionand Sodium Channel Turnover.- Nephrogenic Diabetes Insipidus st[Water and Urea Transport.- Glomerulonephritis and Smad Signaling.- Interstitial Nephritis.- The Pathophysiology of Acute Renal Failure.- Loss of Lean Body Mass in Uremia.- Mechanisms of Renal Allograft Rejection.- Musculoskeletal.- Muscle Development and Differentiation.- Skeletal Muscle Structure and Function.- Stem Cells and Muscle Regeneration.- Skeletal Muscle Hypertrophy and Response to Training.- Muscular Dystrophies.- Rhabdomyosarcomas.- Oncology.- Apoptosis.- Colorectal Cancer.- Breast Cancer.- Lung Cancer.- Discoveries and Frontiers in Prostate Cancer Translational Sciences.- Cutaneous Melanoma.- Applications of Gene Expression Profiling to the Study of Malignant Gliomas.- Acute Myeloid Leukemias.- Acute Lymphoblastic Leukemia.- Chronic Myelogenous Leukemia.- Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia.- Multiple Myeloma.- HIV-1, AIDS, and Related Malignancies.- Hematology.- Disorders of the Red CellMembrane.- Paroxysmal Nocturnal Hemoglobinuria.- Iron Metabolism.- Correction of Genetic Blood Defects by Gene Transfer.- Bone Marrow Failure Syndromes.- Coagulation Disorders.- Advances in Transfusion Safety.- Immunology And Infectious Diseases.- Immunomodulation.- HIV Molecular Biology, Treatment Resistance.- Cellular and Molecular Aspects of Pneumonia.- Molecular Pathogenesis of Fungal Infections.- Dermatology.- Psoriasis.- Atopic Dermatitis.- Pemphigus Foliaceus, Pemphigus Vulgaris, Paraneoplastic Pemphigus, Bullous Pemphigoid, Herpes Gestationis, and Cicatricial Pemphigoid.- Systemic Lupus Erythematosus.- Systemic Sclerosis.- Diseases With Signaling and Transcriptional Abnormalities.- Genetic Skin Diseases With Neoplasia.- Melanoma and Nevi.- Disorders of Hypopigmentation.- Epidermolysis Bullosa.- Connective Tissue Disorders.- Genetic Epidermal Diseases.- Genetic Hair and Nail Defects.- Metabolic Genetic DisordersWith Prominent Skin Findings.- Heritable Conditions Affecting Tissues of the Oral Cavity.- Neurology.- The Genetic Basis of Human Cerebral Cortical Malformations.- Muscular Dystrophies.- Channelopathies of the Nervous System.- Charcot-Marie-Tooth Disease and Related Peripheral Neuropathies.- Amyotrophic Lateral Sclerosis and Related Motor Neuron Disorders.- Trinucleotide Repeat Disorders.- Parkinson’s Disease.- Genetics and Neurobiology of Alzheimer’s Disease and Frontotemporal Dementias.- Prion Diseases.- Narcolepsy and Other Neurological Sleep Disorders.- Neurofibromatosis 1 and 2.- Axonal Regeneration and Recovery From Chronic Central Nervous System Injury.- Psychiatry.- Molecular Mechanisms Regulating Behavior.- The Complex Genetics of Psychiatric Disorders.- Treating Depression.- Anxiety Disorders.- Trauma Spectrum Disorders.- Schizophrenia.- Disorders of Substance Abuse and Dependence.- Autism and Related Disorders.

Winner of the Book of the Year Award from Doody's Health Science Book Review Journal "The selection of topics, the ability of the contributors to present complex topics in a clear, concise manner, and the format should all contribute to making this book the standard text and reference in its field. It should be in the collection of every medical library and on the bookshelf of every physician interested in keeping up with the transformation of medicine by molecular genetics." 5 Stars-Doody's Health Science Book Review Journal. "...bridge[s] the current gap between basic science and the bedside. It will thus be useful to researchers and clinicians alike. With more than 100 chapters covering a wide variety of topics, its distinguished cohort of section editors, and its abundant tables and illustrations, it provides an accessible and much needed manual to the present and the future of molecular genetics." -Francis S. Collins, MD, PhD "...a first-class reference textbook. The format of this book is easy to follow and is relevant to the way in which medicine is currently practiced. Its division into the traditional disciplines of medicine makes it easy to identify how molecular developments have enhanced our medical knowledge, diagnostic potentials and therapeutic options...The editor-in-chief, his section editors and the contributing authors should all be congratulated on a superb job." -Molecular Medicine Today "Because molecular medicine has already started to become an integral part of medical practice, there is a growing need to integrate it into the medical school curriculum and medical education in general. Principles of Molecular Medicine is well suited to serving this purpose...closing the gap between basic science and the bedside. The book is organized according to organ systems and comprises more than 120 chapters, each written by outstanding specialists...The various facets of human hereditary disorders, including genetic counseling and molecular diagnostic testing, are clearly and comprehensively presented...the book is well written and attractive...[and] is a valuable resource that will certainly appeal to clinicians, researchers, teachers, and students alike. It will also be of value to those involved in a particular area of molecular medicine who need a reference manual in which to find information on aspects of the field in which they are less familiar...a valuable reference for anyone with an interest in the achievements and the potential of molecular medicine." -Michael Gooses, MD review in the May 20, 1999 issue of the New England Journal of Medicine "...succeeds in giving a remarkable, mostly up-to-date overview of molecular medicine such as has not been available between two covers hitherto." -New England Journal of Medicine