GnRH Neuron and its Control

Editors:Allan E. Herbison, University of Otago, New Zealand. Tony M. Plant, University of Pittsburgh, USA.

• List of Contributors viiSeries Preface xiPreface xiiiAbout the Companion Website xvPart I Historical Introduction to the GnRH Neuron1 The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built 3Tony M. Plant and Allan E. HerbisonPart II GnRH Neuron Development2 Prenatal Development of GnRH Neurons 15Yufei Shan and Susan Wray3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin–GnRH NeuronalNetwork 43Hiroko Tsukamura, Kei‐ichiro Maeda and Yoshihisa Uenoyama4 Postnatal Development of GnRH Neuronal Function 61Ei TerasawaPart III GnRH Neuron Biology5 Regulation of GnRH Gene Expression 95Hanne M. Hoffmann and Pamela L. Mellon6 Morphology of the Adult GnRH Neuron 121Rebecca E. Campbell7 The Anatomy of the GnRH Neuron Network in the Human 149Katalin Skrapits and Erik Hrabovszky8 Electrophysiology of Rodent GnRH Neurons 177Richard Piet and Allan E. Herbison9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish 203Yoshitaka OkaPart IV Regulation of GnRH Neuron Function10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH NeuronalFunction 227Vincent Prevot and Ariane Sharif11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons 259Michael Candlish, Philipp Wartenberg and Ulrich Boehm12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats 289Robert L. Goodman, Satoshi Okhura, Hiroaki Okamura,  Lique M. Coolen and Michael N. Lehman13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen 325Iain Clarke14 Influence of Stress on the GnRH Neuronal Network 357Pasha Grachev and Kevin T. O’Byrne15 Metabolic Regulation of GnRH Neurons 383Maggie C. Evans and Greg M. Anderson16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel CentralMechanisms Governing Mammalian Reproduction 411Sébastien Milesi, Paul Klosen and Valerie SimonneauxPart V GnRH in the Clinic17 Human Genetics of GnRH Neuron Function 445A. Kemal Topaloglu and L. Damla Kotan18 Modulators of GnRH Secretion and Therapeutic Applications 469Claire L. Newton, Ross C. Anderson and Robert P. MillarIndex 499

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