This cutting-edge, interdisciplinary volume describes established and state of the art approaches for exploring the pathways that influence and control appetite, including: behavioural, electrophysiological, neuroanatomical, gene knockout and pharmacological techniques. The book presents key peptide and neurotransmitter systems, together with newly emerging concepts of metabolic signalling and hypothalamic inflammation. The impact of early life experience on neuroendocrine appetite circuits is also looked at, including early programming of these circuits by circulating hormones. Finally, new emerging therapeutic approaches to appetite suppression are discussed, including those linked to bariatric (weight loss) surgery.Neuroendocrinology of Appetite is especially focused on established and emerging technologies and approaches for investigating appetite control. It is written so as to provide an overview of sufficient depth for an undergraduate or new scientist in the field to come up to speed in the complementary approaches used by researchers in this field. Taking an interdisciplinary approach, the book aims to appeal to all those with a basic, clinical or therapeutic interest in research into obesity and eating disorders.
Professor Suzanne L Dickson, The Sahlgrenska Academy of the University of Gothenberg, SwedenProfessor Julian G. Mercer, Rowett Institute of Nutrition and Health, University of Aberdeen, UK
Foreword viiList of Contributors ixSeries Preface xiAbout the Companion Website xiii1 Neuroanatomy of Feeding Pathways 1Brian J. Oldfield, Paul N. Mirabella, and Aneta Stefanidis2 Afferent Endocrine Control of Eating 24Wolfgang Langhans and Jens Juul Holst3 Ontogeny of Neuroendocrine Feeding Circuits 55Sophie Croizier and Sebastien G. Bouret4 Hypothalamic Peptides and Meal Patterns 76Yada Treesukosol and Timothy H. Moran5 Food Hedonics: Insight from Animal Models 90Karolina P. Skibicka and Scott E. Kanoski6 Functional and Anatomical Dissection of Feeding Circuits 112Deniz Atasoy and Scott M. Sternson7 Exploring Appetite and Hypothalamic Circuitry through Manipulating Gene Expression 134Tara Jois and Mark W. Sleeman8 Electrophysiology of the Appetite‐Regulating Circuits of the Hypothalamus 151Nancy Sabatier, John Menzies, and Gareth Leng9 Functional Neuroimaging of Appetite and Gut–Brain Interactions 174Paul A.M. Smeets and Hubert Preissl10 Appetite Disorders: From Binge Eating to Anorexia Nervosa 201Mathieu Méquinion, Susanne la Fleur, and Odile Viltart11 Future Prospects of the Management of Appetite Disorders Bariatric Surgery 224Carel le Roux and Karl Neff12 Discovery of New Drugs for Weight Loss and Prevention of Weight Regain 247Anders Lehmann, Udo Bauer, Stephan Hjorth, Rudolph L. Leibel and Michael RosenbaumIndex 000