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The student of Cushing's Disease and the HPA axis will find elucidation of the latest basic scientific advances, coupled with patient friendly guidelines for clinical diagnosis and management of an extremely challenging neuroendocrine disorder.
1. Ontogeny of the pituitary corticotroph system.- 2. Proopiomelanocortin gene expression in man.- 3. Multifactorial regulation of the corticotroph axis: animal models.- 4. CRH-receptors and their ligands.- 5. ACTH precursors in different pathological conditions.- 6. Interactions between the hypothalamo-pituitary-adrenal axis and the immunological system.- 7. Pituitary corticotroph SOCS-3: an important regulator of POMC gene expression.- 8. The melanocortin pathway and food intake.- 9. The ACTH receptor and its mutations.- 10. Leptin and the hypothalamo-pituitary-adrenal axis.- 11. Cushing’s syndrome due to aberrant adrenal hormone receptors.- 12. Cushing’ s syndrome - The diagnosis and diffrential diagnosis.- 13. Lost and found: The pars intermedia of the human pituitary and its role in the histogenesis of silent “corticotroph” adenomas.- 14. Therapeutic strategies in Cushing’ s disease.- 15. Syndromes of glucocorticoid resistance.
