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The purpose of this book is to bring together the many different aspects of and recent discoveries in the understanding of pancreatic endocrine development and its close links to endocrine cell physiology and dysfunction in diabetes. The intention is to combine the knowledge from clinical observations in certain diabetic syndromes with the rapidly growing insights derived from basic molecular biological investigation. At the end of the book, future impacts of these studies are outlined in which the knowledge that is gained from basic studies will be translated into new forms of treatment for diabetes. It is hoped that this book will serve established investigators, newcomers to the diabetes research community, and clinicians interested in the molecular basis of the syndromes that they encounter.
1. An Historical and Phylogenetic Perspective of Islet-Cell Development.- 2. Glucose Signalling to Transcription Factors of the Insulin Gene.- 3. ?-Cell Dysfunction and Chronic Hyperglycaemia.- 4. Glucose Toxicity of the Pancreatic ?-cell.- 5. The ?-Cell and Regulation of Glucagon Gene Transcription.- 6. The KATP Channel and the Sulfonylurea Receptor.- 7. Glucagon-Like Peptide-1: An Insulinotropic Hormone with Potent Growth Factor Actions at the Pancreatic Islets of Langerhan.- 8. Communication of Islet Cells: Molecules and Functions.- 9. Soluble Factors Important for Pancreas Development.- 10. Role of Mesenchymal-Epithelial Interactions in Pancreas Development.- 11. Homeodomain Proteins in Pancreas Development.- 12. bHLH Factors and Notch in Pancreatic Development.- 13. Identification, Biological Functions, and Contribution to Human Diabetes of Islet-Brain 1.- 14. Pax4 and Pax6 in Islet Differentiation.- 15. The Role of the Hepatocyte Nuclear Factor Network in Glucose Homeostasis.- 16. Regulation of PDX-1 Gene Expression.- 17. Mechanisms of Postnatal ?-Cell Mass Regulation.- 18. Genetic Models of Insulin Resistance: Alterations in ?-Cell Biology.- 19. Clinical Consequences of Genetic Defects in ?-Cell Genes.- 20. Pathophysiology of Glut2 in Diabetes Mellitus.- 21. Use of a Cre-LoxP Strategy in Mice to Determine the Cell-Specific Roles of Glucokinase in MODY-2.- 22. Development of ?-Cell Lines for Transplantation in Type 1 Diabetes Mellitus.- 23. Gene Therapeutic Approaches for ?-Cell Replacement.- Colour Figures.
'A very interesting text for both research and clinical endocrinologists.' Journal of Pediatric Endocrinology and Metabolism, 15:4 (2002)
