Tumor Microenvironment

Jacinta Serpa is an Assistant Professor and Senior Researcher at the Universidade Nova de Lisboa.

• Preface.- Tumor microenvironment a job of several holders.- Tumor microenvironment- a selective pressure boosting cancer.- Lactate and lactate transporters as key players in the maintenance of the Warburg effect.- Section 1. Adaptive metabolic features are sustained by tumor microenvironment.- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis.-  Gut microbiota and cancer of the host: colliding interests.- Metabolic plasticity of tumor cells: how they do adapt to food deprivation.- Multifaceted oncogenic role of adipocytes in the tumour microenvironment.- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology.- Monocytes and macrophages in cancer: unsuspected roles.- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression.-  Microenvironment driven metabolic adaptation in melanoma.- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis.- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt.- The bone marrow niche - the tumor microenvironment that ensures leukemia progression.- Section 3. Metabolic fitness and therapy response in cancer.- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer.- The metabolic remodelling in lung cancer and its putative consequence in therapy response.- Hydrogen sulfide metabolism and signaling in the tumor microenvironment.- Using metabolic adaptation to design new drugs.- Metabolomics- a new way of screening cancer.- NMR as a tool for metabolomics.- Section 5. Animal models- addressing cancer microenvironment.- Animal models to study cancer and its microenvironment.- Modulating the metabolic phenotype of cancer microenvironment.- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae.- Section 6. In vitroand ex vivo cancer models.- In vitro and ex vivo models- the tumor microenvironment in a flask.- Index.