Tumor Microenvironment

The Main Driver of Metabolic Adaptation

Häftad, Engelska, 2021

2 229 kr

Beställningsvara. Skickas inom 10-15 vardagar

Fri frakt för medlemmar vid köp för minst 249 kr.

Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics.In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells.

Produktinformation

Utgivningsdatum2021-03-05
Mått178 x 254 x 23 mm
Vikt954 g
FormatHäftad
SpråkEngelska
SerieAdvances in Experimental Medicine and Biology
Antal sidor443
FörlagSpringer Nature Switzerland AG
ISBN9783030340278

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Onkologi inom Medicin
Medicinsk utrustning och medicinska tekniker inom Medicin
Cellbiologi inom Naturvetenskap och teknik
Fysiologi inom Medicin

Preface.- Tumor microenvironment a job of several holders.- Tumor microenvironment- a selective pressure boosting cancer.- Lactate and lactate transporters as key players in the maintenance of the Warburg effect.- Section 1. Adaptive metabolic features are sustained by tumor microenvironment.- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis.- Gut microbiota and cancer of the host: colliding interests.- Metabolic plasticity of tumor cells: how they do adapt to food deprivation.- Multifaceted oncogenic role of adipocytes in the tumour microenvironment.- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology.- Monocytes and macrophages in cancer: unsuspected roles.- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression.- Microenvironment driven metabolic adaptation in melanoma.- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis.- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt.- The bone marrow niche - the tumor microenvironment that ensures leukemia progression.- Section 3. Metabolic fitness and therapy response in cancer.- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer.- The metabolic remodelling in lung cancer and its putative consequence in therapy response.- Hydrogen sulfide metabolism and signaling in the tumor microenvironment.- Using metabolic adaptation to design new drugs.- Metabolomics- a new way of screening cancer.- NMR as a tool for metabolomics.- Section 5. Animal models- addressing cancer microenvironment.- Animal models to study cancer and its microenvironment.- Modulating the metabolic phenotype of cancer microenvironment.- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae.- Section 6. In vitroand ex vivo cancer models.- In vitro and ex vivo models- the tumor microenvironment in a flask.- Index.