Toxicogenomics in Predictive Carcinogenicity

Dr Michael D. Waters is currently a Consultant with Integrated Laboratory Systems Inc. He is also an Adjunct Professor of Toxicology at the University of North Carolina at Chapel Hill and of Pharmacology and Toxicology at Duke University. He is Editor of Mutation Research - Reviews in Mutation Research. He has over 35 years of experience as a biochemist, genetic toxicologist, toxicogenomics and information scientist. Over the last 20 years Dr Waters has also worked extensively on database development; designing and conducting genotoxicity assays and chemoprevention studies in in vitro models; and studying genomics, clinical and toxicologic pathology.Dr Russell S. Thomas is Director of the National Center for Computational Toxicology with the U.S. Environmental Protection Agency. Prior to this he was Director of the Institute for Chemical Safety Sciences at The Hamner Institutes for Health Sciences for over 10 years. Dr. Thomas also maintains an adjunct faculty appointment in the Division of Pharmacogenomics and Individualized Therapy at the University of North Carolina at Chapel Hill. Dr. Thomas has additionally been active in molecular biology and genomics research at the McArdle Cancer Research Laboratory at the University of Wisconsin.

• Introduction to Predictive Toxicogenomics for Carcinogenicity;Genomic Biomarkers in Cell-based Drug Screening;Toxicogenomics In Vitro: Gene Expression Signatures for Differentiating Genotoxic Mechanisms;In Vivo Signatures of Genotoxic and Non-Genotoxic Chemicals;Transcriptomic Dose-Response Analysis for Mode of Action and Risk Assessment;Using transcriptomics to evaluate thresholds in genotoxicity dose-response;Dissecting Modes of Action of Non-Genotoxic Carcinogens;Human Embryonic Stem Cells as Biological Models to Examine the Impact of Xenobiotics on the Genome and Epigenome;Novel Data Streams in the Assessment of Mutagenicity and Carcinogenicity: Implications for Cancer Hazard Assessment;Conazoles and Cancer, a Review;Application of Transcriptomics in Exposed Human Populations: Benzene as an Example;Toxicogenomics Case Study: Furan;The Parallelogram Approach to Assess Human Relevance of Toxicogenomics Derived Toxicity Pathways in Human Health Risk Assessment;Bioinformatics of Genomics in the Assessment of Cancer;