The Origins of Genome Architecture

Inbunden, Engelska, 2007

2 849 kr

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Published by Sinauer Associates, an imprint of Oxford University Press. With official genomic blueprints now available for hundreds of species, and thousands more expected in the near future, the field of biology has been forever transformed. Such readily accessible data have encouraged the proliferation of adaptive arguments for the evolution of gene and genomic features, often with little or no attention being given to simpler and more powerful alternative explanations. By integrating the central observations from molecular biology and population genetics relevant to comparative genomics, Lynch shows why the details matter.Presented in a nontechnical fashion, at both the population-genetic and molecular-genetic levels, this book offers a unifying explanatory framework for how the peculiar architectural diversity of eukaryotic genomes and genes came to arise. Under Lynch's hypothesis, the genome-wide repatterning of eukaryotic gene structure, which resulted primarily from nonadaptive processes, provided an entirely novel resource from which natural selection could secondarily build new forms of organismal complexity.

Produktinformation

Utgivningsdatum2007-03-03
Mått246 x 188 x 30 mm
Vikt1 111 g
FormatInbunden
SpråkEngelska
Antal sidor512
FörlagOUP USA
ISBN9780878934843

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Biovetenskap inom Naturvetenskap och teknik

Michael Lynch is Distinguished Professor of Biology at Indiana University. He received his B.S. in Biology from St. Bonaventure University, and his Ph.D. in Ecology from the University of Minnesota. Dr. Lynch has served as President of both the Society for the Study of Evolution and the American Genetic Association, and is a past council member of the Society for Molecular Biology and Evolution, and a fellow of the American Academy of Arts and Sciences. His research is focused on mechanisms of evolution at the gene, genomic, cellular, and phenotypic levels, with special attention being given to the roles of mutation, random genetic drift, and recombination.

The Origin of Eukaryotes.- Genome Size and Organismal Complexity.- The Human Genome.- Why Population Size Matters.- Three Keys to Chromosomal Integrity.- The Nucleotide-composition Landscape.- Mobile Genetic Elements.- Genomic Expansion by Gene Duplication.- Genes in Pieces.- Transcription and Regulatory-region Complexity.- Expansion and Contraction of Organelle Genomes.- Sex Chromosome Evolution.- Genomfart.

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