Evolution and Selection of Quantitative Traits

Inbunden, Engelska, 2018

AvBruce Walsh,Michael Lynch,USA) Walsh, Bruce (Professor, Professor, Department of Ecology and Evolutionary Biology, The University of Arizona,USA) Lynch, Michael (Professor and Director, Professor and Director, Biodesign Center for Mechanisms of Evolution, Arizona State University

2 599 kr

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Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences.

Produktinformation

Utgivningsdatum2018-07-12
Mått223 x 284 x 62 mm
Vikt3 878 g
FormatInbunden
SpråkEngelska
Antal sidor1 496
FörlagOUP OXFORD
ISBN9780198830870

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik

Bruce Walsh is Professor of Ecology and Evolutionary Biology at the University of Arizona. He has taught advanced classes on quantitative genetics in 25 different countries and his research interests are at the interface of biology, genetics, mathematical modelling, and statistics. He is also an avid lepidopterist, having described over two dozen species of new moths and has three species named after him.Michael Lynch is Professor in the Schoool of Life Sciences at Arizona State University and is Center Director of the Biodesign Center for Mechanims of Evolution. His research is focused on mechanisms of evolution at the gene, genomic, cellular, and phenotypic levels, with special attention being given to the roles of mutation, random genetic drift, and recombination. He is a member of the US National Academy of Sciences, and a fellow of the American Academy of Arts and Sciences.

PrefaceIIntroduction1: Changes in quantitative traits over timeIIEvolution at one and two loci2: Neutral evolution in one- and two-locus systems3: The genetic effective size of a population4: The nonadaptive forces of evolution5: The population genetics of selection6: Theorems of natural selection: Results of Price, Fisher, and Robertson7: Interaction of selection, mutation, and drift8: Hitchhiking and selective sweeps9: Using molecular data to detect selection: Signatures from recent single events10: Using molecular data to detect selection: Signatures from multiple historical eventsIIIDrift and quantitative traits11: Changes in genetic variance induced by drift12: The neutral divergence of quantitative traitsIVShort-term response on a single character13: Short-term changes in the mean: 1. The breeder's equation14: Short-term changes in the mean: 2. Truncation and threshold selection15: Short-term changes in the mean: 3. Permanent versus transient response16: Short-term changes in the variance: 1. Changes in the additive variance17: Short-term changes in the variance: 2. Changes in environmental variance18: Analysis of short-term selection experiments: 1. Least-squares approaches19: Analysis of short-term selection experiments: 2. Mixed-model and bayesian approaches20: Selection response in natural populationsVSelection in structured populations21: Family-based selection22: Associative effects: Competition, social interactions, group and kin selection23: Selection under inbreedingVIPopulation-genetic models of trait response24: The infinitesimal model and its extensions25: Long-term response: 1. Deterministic aspects26: Long-term response: 2. Finite population size and mutation27: Long-term response: 3. Adaptive walks28: Maintenance of quantitative genetic variationVIIMeasuring selection on traits29: Individual fitness and the measurement of univariate selecton30: Measuring multivariate selectionVIIIAppendicesA1: Diffusion theoryA2: Introduction to Bayesian AnalysisA3: Markov Chain Monte Carlo and Gibbs samplingA4: Multiple comparisons: Bonferroni corrections, false-discovery rates, and meta-analysisA5: The geometry of vectors and matrices: Eigenvalues and eigenvectorsA6: Derivatives of vectors and vector-valued functionsLiterature CitedAuthor IndexOrganism and Trait IndexSubject Index

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Genetics and Analysis of Quantitative Traits

USA) Walsh, Prof Bruce (Professor, Ecology & Evolutionary Biology, University of Arizona, UK) Visscher, Prof Peter M. (Professor of Quantitative Genetics, University of Oxford, USA) Lynch, Prof Michael (Director, Center for Mechanisms of Evolution, Arizona State University, Bruce Walsh, Peter M. Visscher, Michael Lynch, Peter M Visscher

Inbunden

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