Studies on Retinal and Choroidal Disorders

Robert D Stratton, MD is the Founder of Erie Retinal Surgery from 1984 to 2008 and past Head of the Division of Retinal Surgery, Department of Ophthalmology, University of Florida School of Medicine from 1980 to 1984 . He is a fellow of the American Board of Ophthalmology, the American Academy of Ophthalmology, and the American College of Surgeons. Dr. Stratton's interests include vitreous and retinal diseases and surgery, and has 30 years experience in clinical practice. He is currently Courtesy Assistant Professor in the Department of Ophthalmology, University of Florida and Adjunct Assistant Professor in the Division of Small Animal Clinical Sciences, School of Veterinary Medicine, University of Florida. William W Hauswirth , PhD, is the Rybaczki-Bullard Professor of Ophthalmology and Molecular Genetics at the University of Florida College of Medicine. Dr. Hauswirth is, in part, responsible for determining the mechanism of replication of adeno-associated virus (AAV) DNA and the discovery of mitochondrial DNA heteroplasmy in mammals, the basis of mitochondrial disease. He collaborated on the first successful rescue of a dominant genetic disease in animals and the first restoration of vision for a recessive retinal disease. He also demonstrated that AAV mediated gene therapy could cure red-green color blindness in monkeys. Dr Hauswirth's current interests involve the delivery and testing of potentially therapeutic genes for many eye diseases in natural and transgenic animal models of human disease. Thomas W. Gardner is Professor of Ophthalmology and Visual Sciences and Molecular and Integrative Physiology at the University of Michigan in Ann Arbor, Michigan. He was previously the Jack and Nancy Turner Professor of Ophthalmology and Cellular and Molecular Physiology at the Penn State College of Medicine. Dr. Gardner's interests include vitreoretinal diseases and surgery, and clinical and experimental diabetic retinopathy. He currently serves as Associate Editor of Diabetes and Acta Ophthalmologica and on the editorial board of the Journal of Ocular Biology, Diseases and Informatics. He served previously on the editorial board of Diabetes, and is the former Editor-in-Chief of Current Eye Research.

• Review of Emerging Treatments for Age-Related Macular Degeneration.- Complement Pathways and Oxidative Stress in Models of Age-Related Macular Degeneration.- Oxidative Modifications As Triggers of AMD Pathology.- Role of Malondialdehyde in the Age-Related Macular Degeneration.- Bisretinoid Lipofuscin in the Retinal Pigment Epithelium: Oxidative Processes and Disease Implications.- Age-related Changes in RPE Lipofuscin Leads to Hydrophobic Polymers.- Docosahexaenoic Acid Signalolipidomics in the Homeostatic Modulation of Photoreceptor/Retinal Pigment Epithelial Cell Integrity During Oxidative Stress.- Role of Photoreceptor Retinol Dehydrogenases in Detoxification of Lipid Oxidation Products.- Glutathione Metabolism and its Contribution to Anti-Apoptotic Properties of α-Crystallins in the Retina.- The Role of Mitochondrial Oxidative Stress in Retinal Dysfunction.- Endoplasmic Reticulum Response to Oxidative Stress in RPE.- The Role of Iron in Retinal Diseases.- Mechanisms of Pathological VEGF Production in the Retina and Modification with VEGF-Antagonists.- NADPH Oxidase in Choroidal Neovascularization.- Deposition and Oxidation of Lipoproteins in Bruch’s Membrane and Choriocapillaris are “Age-Related” Risk Factors with Implications in Age-Related Macular Degeneration.- Hepatocyte Growth Factor Protection of Retinal Pigment Epithelial Cells.- The Role of Oxidative Stress in the Retinal Lesion of Ccl2/Cx3cr1 Deficiency Mouse.- Oxidative Stress and Systemic Changes in Age-Related Macular Degeneration.- Cerium Oxide Nanoparticle Reduction of Oxidative Damage in Retina.- Transformation of Progenitor Cells for Treatment of Retinal Disease.- Natural Compounds in Retinal Diseases.- Serotonin 5-HT1A Receptor Agonists in Oxidative Stress and Retinal Disease.- Anti-VEGF Monotherapy Treatment Strategies for Neovascular AMD.- Combination Treatment Strategies in Neovascular AMD.- Dysfunction of Circulating Endothelial Progenitor Cellsin Diabetic Retinopathy.- Nitric Oxide Synthase in Retinal Vascular Diseases.- Lipid Hydroperoxide Induced Leukocyte-Endothelium Interaction in the Retinal Microcirculation.- The Role of Reactive Oxygen Species and Oxidative Signaling in Retinopathy of Prematurity.- VEGF Inhibitor Induced Oxidative Stress in Retinal Ganglion Cells.- The Role of the Macular Carotenoids as a Blue Light Filter and an Antioxidant.- Macular Pigment Carotenoids and Their Roles in Human Eye Health and Diseases.