Signal Transduction in Cancer

• Receptors.- Growth, Survival and Migration: The Trk to Cancer.- The Role of Growth Factor Signaling in Malignancy.- TGF-? Signaling Alterations in Cancer.- Notch in Malignancy.- Intracellular Pathways.- cAMP Signaling in Cancer Genesis and Treatment.- PI3K/PTEN/Akt Pathway.- Wnt Signaling in Human Cancer.- Ras Signaling, Deregulation of Gene Expression and Oncogenesis.- Role of the RB Tumor Suppressor in Cancer.- Transcription Factors.- The Rel/NF-?B/I?B Signal Transduction Pathway and Cancer.- STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies.- Steroid Hormone Receptor Signaling in Cancer.- Cell Death Pathways.- Cell Death Signaling in Malignancy.- Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies.

"While the chapters in this book are necessarily brief, all are extensively referenced and msot authors have included historical as well as more recent references. Thus this book is an excellent summary of important signalling pathways in cancer that will be useful for students and researchers. It will serve as a resource for general and specialised knowledge regarding these pathways as well as a platform for more detailed research." (Cancer Forum, 27:3)