Sarcopenia

Dominique Meynial-Denis studied Biochemistry and Molecular Biology at the University Paul Sabatier of Toulouse, France and obtained her Ph.D. degree on intermolecular interactions between drug and plasma proteins followed by magnetic resonance spectroscopy (MRS) at the same University in 1985. Since 1986, she has worked as a scientist at the National Institute of Agricultural Research (INRA) in Clermont-Ferrand in a Department focussing on Human Nutrition. Consequently, she became a Nutritionist and specialised her research on Sarcopenia and Aging in 1994. She applied MRS to metabolic pathways of amino acids in muscle during aging. Dominique Meynial-Denis received a second Ph.D. in 1998 on amino acid fluxes throughout skeletal muscle during aging. More recently, she has mainly been interested in the effect of glutamine supplementation in advanced age. She is a member of the French Society of Enteral and Parenteral Nutrition (SFNEP), of the European Society of Clinical Nutrition and Metabolism (ESPEN), of the Société Française de Nutrition (SFN), of the International Association of Gerontology and Geriatrics (IAGG) and of the Société Francophone de Gérontologie et Gériatrie (SFGG). She is a regular referee to different international journals on Nutrition as well as Aging.

• Basics of Sarcopenia: Definition and Challenges of Sarcopenia Research. Definitions of Sarcopenia. New Data on Sarcopenia. Models of Accelerated Sarcopenia. Sarcopenia in Physical Frailty. Molecular and Cellular Aspects of Sarcopenia. The Role of Imaging Techniques in the Diagnosis of Sarcopenia. Nutrient Sensing and mTORC1 Regulation in Sarcopenia. Different Adaptation of Ubiquitin-Proteasome and Lysosome-Autophagy. Signaling in Sarcopenic Muscle. Myokines in Aging Muscle. The Contribution of Satellite Cells to Skeletal Muscle Aging. Muscle Stem Cell Microenvironment in Sarcopenia. Sarcopenia and Oxidative Stress: From the Bench to Therapeutic Strategies. Alterations in Muscle Protein Turnover in the Aging Process. Muscle Protein Turnover and Sarcopenia in the Elderly: The Effects of Nutrition. The Relationship between Muscle Mitochondrial Turnover and Sarcopenia. Skeletal Muscle Fat Infiltration with Aging: An Important Factor of Sarcopenia. Recent Advances Limiting Sarcopenia and Supporting Healthy Aging. Nutritional Modulation of Mitochondria-Associated Death Signaling in Sarcopenia. Beneficial Effects and Limitations of Strategies (Nutritional or Other) to Limit Muscle Wasting due to Normal Aging. Applications. Muscle Impairments or Diseases Due to the Frailty Induced by Sarcopenia. Declines in Whole Muscle Function with Aging: The Role of Age-Related Alterations in Contractile Properties of Single Skeletal Muscle Fibers. Sarcopenic Dysphagia, Presbyphagia, and Rehabilitation Nutrition. Complications due to Sarcopenia in Acute or Chronic Diseases. Wasting and Cachexia in Chronic Kidney Disease. Sarcopenia and Parkinson’s Disease: Molecular Mechanisms and Clinical Management. Sarcopenic Obesity in the Elderly. Sum Up and Future Research.

'This book reflects the evolving research on sarcopenia and its fundamental applications. The purpose is to present a comprehensive review of research in the field of sarcopenia. Instead of having to read through hundreds of journal articles on sarcopenia, readers can find a chapter with up-to-date summaries of evidence-based medicine and research in this book. 'Physicians, medical students, nutritionists, and non-clinical sarcopenia researchers will find this book helpful. It is written at a high scientificlevel and expects readers have baseline knowledge of sarcopenia. The author and contributors write at a level for their colleagues or peers. The chapters on molecular and cellular aspects of sarcopenia are challenging but eye opening for clinicians who do not work in lab settings. The chapters on clinical findings and management will be more readily understood by all. The result is a well-rounded, applicable knowledge of sarcopenia, brought to life by leading international sarcopenia researchers. 'No other sarcopenia book on the market that I have read compares to this one. It is comprehensive but not overwhelming, futuristic but applicable. The most unique feature is the author's ability to link multiple scientific disciplines from molecular biology to nutrition to explain one of the most prevalent and destructive syndromes in aging.' Weighted Numerical Score: 88 - 3 Stars-- Issam el bizri, Dartmouth Geisel School of Medicine