Sarcopenia

Alfonso J. Cruz-Jentoft, MD, Professor, Geriatrics, Universidad Europea de Madrid, and Director of Geriatric Medicine, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.John E. Morley, MD, Professor, Geriatrics, St Louis University Medical School, St Louis, MO, USA.

• List of Contributors viiPreface xiii1 Definitions of Sarcopenia 1Alfonso J. Cruz‐Jentoft, Beatriz Montero‐Errasquin and John E. Morley2 Epidemiology of Muscle Mass Loss with Age 11Marjolein Visser3 The Role of Mitochondria in Age‐Related Sarcopenia 19Luigi Ferrucci, Marta Zampino, Paul Coen and Bret H. Goodpaster4 Motor Unit Remodeling 35Ben Kirk and Mathew Piasecki5 Nutrition, Protein Turnover and Muscle Mass 45Stéphane Walrand, Christelle Guillet and Yves Boirie6 Recognizing Persons at Risk for Sarcopenia 63John E. Morley7 Adverse Outcomes and Functional Consequences of Sarcopenia 71Jean Woo8 A Lifecourse Approach to Sarcopenia 77Richard Dodds and Avan Aihie Sayer9 Acute Sarcopenia 95Beatrice Gasperini, Stefano Volpato and Antonio Cherubini10 Sarcopenia, Frailty, and Intrinsic Capacity 115Jurgen M. Bauer and Cornel Sieber11 Osteosarcopenia 127Ben Kirk, Jesse Zanker, Steven Phu and Gustavo Duque12 Sarcopenic Obesity 147Mauro Zamboni, Federica Macchi, Nicole Nori and Andrea P. Rossi13 Sarcopenia and Cognitive Impairment 157Liang‐Kung Chen14 Sarcopenia and Other Chronic Organ Diseases 175Hidenori Arai15 Imaging of Skeletal Muscle 185Thomas F. Lang16 Measurements of Muscle Mass, Equations and Cut‐off Points 199Marjolein Visser and Laura Schaap17 Deuterated Creatine Dilution to Assess Muscle Mass (D3‐Cr Muscle Mass) in Humans: Methods, Early Results, and Future Directions 227Peggy M. Cawthon and William J. Evans18 Measurement of Muscle Strength and Power 239Michael Drey, Sandra Helmers and Jürgen M. Bauer19 Measurements of Physical Performance 253Laura Orlandini, Yves Rolland and Matteo Cesari20 Biomarkers for Physical Frailty and Sarcopenia: A “Two‐Body Problem” 271Anna Picca, Riccardo Calvani and Emanuele Marzetti21 Quality of Life and Sarcopenia 279Charlotte Beaudart, Jean‐Yves Reginster, Olivier Bruyère and Anton Geerinck22 Exercise Interventions to Prevent and Improve Sarcopenia 305Mark D. Peterson and Jose A. Serra23 Nutritional Approaches to Treat Sarcopenia 335Tommy Cederholm, Jurgen M. Bauer and Alfonso J. Cruz‐Jentoft24 Beta‐hydroxy‐beta‐methylbutyrate (HMB) and Sarcopenia 355Francesco Landi, Riccardo Calvani, Anna Picca and Emanuele Marzetti25 The Future of Drug Treatments 367Francesco Landi, Graziano Onder and Rolland Yves26 Sarcopenia: Is It Preventable? 403Stany Perkisas, Keliane Liberman, Ivan Bautmans and Maurits Vandewoude27 Financial Impact of Sarcopenia 421Kristina Norman28 Sarcopenia Management for Clinicians 433Renuka Visvanathan and Solomon YuIndex 441

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