This text contains the papers presented at the 2nd International Symposium on Retinal Pigment Epithelium and at the 4th Meeting of the European Macula Group. The following topics are covered: functions of RPE and Bruch's membrane; RPE cells proliferation and transplantation; fundus imaging; choroidal disorders; central serous chorioretinopathy and other maculopathies; age-related macular degeneration; choroidal neovascularization; diabetes and retinal vascular disorders; macular surgery. In this text, those interested in retinal diseases can find recent findings of clinical and laboratory research, presented by prominent experts in the field.