• Part I Age-Related Macular Degeneration (AMD).- Apolipoprotein E Isoforms and AMD.- Role of Chemokines in Shaping Macrophage Activity in AMD.- Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).- Gene Structure of the 10q26 locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?.- Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.- Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.- A Brief Discussion on Lipid Activated Nuclear Receptors and Their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).- Extracellular Matrix Alterations and Deposit Formation in AMD.- The NLRP3 Inflammasome and its Role in Age-related Macular Degeneration.- Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration.- Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease.- VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration.- Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration.- Gene-diet Interactions in Age-Related Macular Degeneration.- Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration.- Nanoceria: A Potential Therapeutic for Dry AMD.- β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases.- Part II Macular Dystrophies/Inherited Macular Degeneration.- Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.- Mouse Models of Stargardt 3 Dominant Macular Degeneration.- Current Progress in Deciphering Importance of VLC-PUFA in the Retina.- Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-related Macular Degeneration and Potential Therapies.- Part III Inherited Retinal Degenerations.- Hsp90 as a Potential Therapeutic Target in RetinalDisease.- Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes.- A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.- Ablation of Chop Transiently Enhances Photoreceptor Survival But Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin.- Identification of a Novel Gene on 10q22 Causing Autosomal Dominant Retinitis Pigmentosa (adRP).- FAM161A and TTC8 Are Differentially Expressed in Non-allelelic Early Onset Retinal Degeneration.- Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.- RDS Functional Domains and Dysfunction in Disease.- TULP1 Missense Mutations Induces the Endoplasmic Reticulum Unfolded Protein Response Stress Complex (ER-UPR).- Understanding Cone Photoreceptor Cell Death in Achromatopsia.- Geranylgeranylacetone Suppresses N-methyl-N-nitrosourea-induced Photoreceptor Cell Loss in Mice.- My Retina Tracker™: An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases and their Genetic Relatives – A New Resource.- A Mini-Review: Animal Models of GUCY2D Leber Congenital Amaurosis (LCA1).- A Comprehensive Review of Mutations in the MERTK Proto-oncogene.- Part IV In Vivo Imaging and Other Diagnostic Advances.- New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo.- Reliability and repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia.- Quantitative Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is Not Increased in Non-Lesion Areas of Retina.- Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa.- Intra-familial Similarity of Wide-Field Fundus Autofluorescence in InheritedRetinal Dystrophy.- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy.- The Development of a Cat Model of Retinal Detachment and Re-Attachment.- Part V Mechanisms of Degeneration.- The Role of X-Chromosome Inactivation in Retinal Development and Disease.- A Non-canonical Role for β-Secretase in the Retina.- The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors.- The Rate of Vitamin A Dimerization in Lipofuscinogenesis, Fundus Autofluorescence, Retinal Senescence and Degeneration.- Can Vitamin A be Improved to Prevent Blindness due to Age-Related Macular Degeneration, Stargardt Disease and Other Retinal Dystrophies?.- Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina.- Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets.- Neuronal Nitric Oxide Synthase as a Trigger of the N-methyl-N-nitrosourea-induced Photoreceptor Cell Death.- Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases.- Aging and Vision.- Part VI Neuroprotection, Small Molecules & Related Therapeutic Approaches.- The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair.- Retinal Caveolin-1 Modulates Neuroprotective Signaling.- Photoreceptor Neuroprotection: Regulation of Akt activation through Serine/Threonine Phosphatases, PHLPP and PHLPPL.- The Role of AMPK pathway in Neuroprotection.- Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1.- Near-Infrared Photobiomodulation in Retinal Injury and Disease.- Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns.- Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models.- Histone Deacetylase: Therapeutic Targets in Retinal Degeneration.- Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases.- Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury.- Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa.- Part VII Gene Therapy & Antisense.- Gene Therapy for MERTK-Associated Retinal Degenerations.- Tamoxifen-containing Eye Drops Successfully Trigger Cre-mediated Recombination in the Entire Eye.- Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages.-          Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin.- Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies.- Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.- Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes.-Part VIII Stem Cells & Cell-based Therapies.- Regenerative Medicine: Solution in Sight.- Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-derived Retinal Pigment Epithelium Cells.- Human Retinal Pigment Epithelium Stem Cell (RPESC).- Embryonic Stem Cell‐Derived Microvesicles: Could They Be Used for Retinal Regeneration?.- Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders.- Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina.- Interkinetic Nuclear Migration in the Regenerating Retina.- Part IX Photoreceptors & Inner Retina.- Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.- A Novel Approach to Identify Photoreceptor Compartment-Specific Tulp1 Binding Partners.- Thyroid Hormone Signaling and Cone Photoreceptor Viability.- In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.- The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium.- Regulation of Retinal Development Via the Epigenetic Modification of Histone.- The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis.- Identification of Tyrosine O Sulfated Proteins in Cow Retina and the 661W Cell Line.- The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.-Characterization of Antibodies to Identify Cellular Expression of Dopamine.- Receptor 4.- A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.- JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo and After Hypoxia In Vitro.- Cell Fate of Müller Cells During Photoreceptor Regeneration in an MNU-induced Retinal Degeneration Model of Zebrafish.- Polymodal Sensory Integration in Retinal Ganglion Cells.- Pigment Epithelium-derived Factor, a Protective Factor for Photoreceptors In Vivo.- Part X Retinal Pigment Epithelium (RPE).- The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells.- Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo.- Cre Recombinase: You Can’t Live with It, and You Can’t Live without It.- Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells.- Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: maxiK, Cav1.3 and Bestrophin-1.- Lysosomal Trafficking Regulator (LYST).- Live-cell Imaging of Phagosome Motility in Primary Mouse RPE Cells.- RPE Cell and Sheet Properties in Normal and Diseased Eyes.- Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival After Hydrogen Peroxide Damage is Mediated by P38 Kinase.- Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis.- Modulation of V-ATPase by βA3/A1-crystallin in the Retinal Pigment Epithelial Cells.- Proteomic Profiling of Cigarette Smoke Induced Changes in Retinal Pigment Epithelium Cells.- Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress.

“Edited by half a dozen experts, this scientific compendium covers experimental and research topics that happen behind the scenes in the ophthalmology world. … This book is intended for full-time retinal researchers, or clinicians participating in clinical trials who want more insight into retinal research.” (EuroTimes, March, 2017)

• Part I Age-Related Macular Degeneration (AMD).- Apolipoprotein E Isoforms and AMD.- Role of Chemokines in Shaping Macrophage Activity in AMD.- Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).- Gene Structure of the 10q26 locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?.- Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.- Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.- A Brief Discussion on Lipid Activated Nuclear Receptors and Their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).- Extracellular Matrix Alterations and Deposit Formation in AMD.- The NLRP3 Inflammasome and its Role in Age-related Macular Degeneration.- Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration.- Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease.- VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration.- Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration.- Gene-diet Interactions in Age-Related Macular Degeneration.- Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration.- Nanoceria: A Potential Therapeutic for Dry AMD.- β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases.- Part II Macular Dystrophies/Inherited Macular Degeneration.- Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.- Mouse Models of Stargardt 3 Dominant Macular Degeneration.- Current Progress in Deciphering Importance of VLC-PUFA in the Retina.- Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-related Macular Degeneration and Potential Therapies.- Part III Inherited Retinal Degenerations.- Hsp90 as a Potential Therapeutic Target in RetinalDisease.- Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes.- A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.- Ablation of Chop Transiently Enhances Photoreceptor Survival But Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin.- Identification of a Novel Gene on 10q22 Causing Autosomal Dominant Retinitis Pigmentosa (adRP).- FAM161A and TTC8 Are Differentially Expressed in Non-allelelic Early Onset Retinal Degeneration.- Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.- RDS Functional Domains and Dysfunction in Disease.- TULP1 Missense Mutations Induces the Endoplasmic Reticulum Unfolded Protein Response Stress Complex (ER-UPR).- Understanding Cone Photoreceptor Cell Death in Achromatopsia.- Geranylgeranylacetone Suppresses N-methyl-N-nitrosourea-induced Photoreceptor Cell Loss in Mice.- My Retina Tracker™: An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases and their Genetic Relatives – A New Resource.- A Mini-Review: Animal Models of GUCY2D Leber Congenital Amaurosis (LCA1).- A Comprehensive Review of Mutations in the MERTK Proto-oncogene.- Part IV In Vivo Imaging and Other Diagnostic Advances.- New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo.- Reliability and repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia.- Quantitative Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is Not Increased in Non-Lesion Areas of Retina.- Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa.- Intra-familial Similarity of Wide-Field Fundus Autofluorescence in InheritedRetinal Dystrophy.- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy.- The Development of a Cat Model of Retinal Detachment and Re-Attachment.- Part V Mechanisms of Degeneration.- The Role of X-Chromosome Inactivation in Retinal Development and Disease.- A Non-canonical Role for β-Secretase in the Retina.- The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors.- The Rate of Vitamin A Dimerization in Lipofuscinogenesis, Fundus Autofluorescence, Retinal Senescence and Degeneration.- Can Vitamin A be Improved to Prevent Blindness due to Age-Related Macular Degeneration, Stargardt Disease and Other Retinal Dystrophies?.- Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina.- Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets.- Neuronal Nitric Oxide Synthase as a Trigger of the N-methyl-N-nitrosourea-induced Photoreceptor Cell Death.- Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases.- Aging and Vision.- Part VI Neuroprotection, Small Molecules & Related Therapeutic Approaches.- The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair.- Retinal Caveolin-1 Modulates Neuroprotective Signaling.- Photoreceptor Neuroprotection: Regulation of Akt activation through Serine/Threonine Phosphatases, PHLPP and PHLPPL.- The Role of AMPK pathway in Neuroprotection.- Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1.- Near-Infrared Photobiomodulation in Retinal Injury and Disease.- Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns.- Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models.- Histone Deacetylase: Therapeutic Targets in Retinal Degeneration.- Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases.- Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury.- Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa.- Part VII Gene Therapy & Antisense.- Gene Therapy for MERTK-Associated Retinal Degenerations.- Tamoxifen-containing Eye Drops Successfully Trigger Cre-mediated Recombination in the Entire Eye.- Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages.-          Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin.- Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies.- Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.- Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes.-Part VIII Stem Cells & Cell-based Therapies.- Regenerative Medicine: Solution in Sight.- Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-derived Retinal Pigment Epithelium Cells.- Human Retinal Pigment Epithelium Stem Cell (RPESC).- Embryonic Stem Cell‐Derived Microvesicles: Could They Be Used for Retinal Regeneration?.- Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders.- Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina.- Interkinetic Nuclear Migration in the Regenerating Retina.- Part IX Photoreceptors & Inner Retina.- Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.- A Novel Approach to Identify Photoreceptor Compartment-Specific Tulp1 Binding Partners.- Thyroid Hormone Signaling and Cone Photoreceptor Viability.- In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.- The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium.- Regulation of Retinal Development Via the Epigenetic Modification of Histone.- The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis.- Identification of Tyrosine O Sulfated Proteins in Cow Retina and the 661W Cell Line.- The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.-Characterization of Antibodies to Identify Cellular Expression of Dopamine.- Receptor 4.- A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.- JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo and After Hypoxia In Vitro.- Cell Fate of Müller Cells During Photoreceptor Regeneration in an MNU-induced Retinal Degeneration Model of Zebrafish.- Polymodal Sensory Integration in Retinal Ganglion Cells.- Pigment Epithelium-derived Factor, a Protective Factor for Photoreceptors In Vivo.- Part X Retinal Pigment Epithelium (RPE).- The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells.- Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo.- Cre Recombinase: You Can’t Live with It, and You Can’t Live without It.- Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells.- Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: maxiK, Cav1.3 and Bestrophin-1.- Lysosomal Trafficking Regulator (LYST).- Live-cell Imaging of Phagosome Motility in Primary Mouse RPE Cells.- RPE Cell and Sheet Properties in Normal and Diseased Eyes.- Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival After Hydrogen Peroxide Damage is Mediated by P38 Kinase.- Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis.- Modulation of V-ATPase by βA3/A1-crystallin in the Retinal Pigment Epithelial Cells.- Proteomic Profiling of Cigarette Smoke Induced Changes in Retinal Pigment Epithelium Cells.- Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress.

“Edited by half a dozen experts, this scientific compendium covers experimental and research topics that happen behind the scenes in the ophthalmology world. … This book is intended for full-time retinal researchers, or clinicians participating in clinical trials who want more insight into retinal research.” (EuroTimes, March, 2017)

• Part I Age-Related Macular Degeneration (AMD).- Apolipoprotein E Isoforms and AMD.- Role of Chemokines in Shaping Macrophage Activity in AMD.- Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).- Gene Structure of the 10q26 locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?.- Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.- Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.- A Brief Discussion on Lipid Activated Nuclear Receptors and Their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD).- Extracellular Matrix Alterations and Deposit Formation in AMD.- The NLRP3 Inflammasome and its Role in Age-related Macular Degeneration.- Oxidative Stress and the Nrf2 Anti-Oxidant Transcription Factor in Age-Related Macular Degeneration.- Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease.- VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration.- Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration.- Gene-diet Interactions in Age-Related Macular Degeneration.- Challenges in the Development of Therapy for Dry Age-Related Macular Degeneration.- Nanoceria: A Potential Therapeutic for Dry AMD.- β-amyloidopathy in the Pathogenesis of Age-Related Macular Degeneration in Correlation with Neurodegenerative Diseases.- Part II Macular Dystrophies/Inherited Macular Degeneration.- Different Mutations in ELOVL4 Affect Very Long Chain Fatty Acid Biosynthesis to Cause Variable Neurological Disorders in Humans.- Mouse Models of Stargardt 3 Dominant Macular Degeneration.- Current Progress in Deciphering Importance of VLC-PUFA in the Retina.- Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-related Macular Degeneration and Potential Therapies.- Part III Inherited Retinal Degenerations.- Hsp90 as a Potential Therapeutic Target in RetinalDisease.- Leber Congenital Amaurosis: Genotypes and Retinal Structure Phenotypes.- A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.- Ablation of Chop Transiently Enhances Photoreceptor Survival But Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin.- Identification of a Novel Gene on 10q22 Causing Autosomal Dominant Retinitis Pigmentosa (adRP).- FAM161A and TTC8 Are Differentially Expressed in Non-allelelic Early Onset Retinal Degeneration.- Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.- RDS Functional Domains and Dysfunction in Disease.- TULP1 Missense Mutations Induces the Endoplasmic Reticulum Unfolded Protein Response Stress Complex (ER-UPR).- Understanding Cone Photoreceptor Cell Death in Achromatopsia.- Geranylgeranylacetone Suppresses N-methyl-N-nitrosourea-induced Photoreceptor Cell Loss in Mice.- My Retina Tracker™: An On-line International Registry for People Affected with Inherited Orphan Retinal Degenerative Diseases and their Genetic Relatives – A New Resource.- A Mini-Review: Animal Models of GUCY2D Leber Congenital Amaurosis (LCA1).- A Comprehensive Review of Mutations in the MERTK Proto-oncogene.- Part IV In Vivo Imaging and Other Diagnostic Advances.- New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo.- Reliability and repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia.- Quantitative Autofluorescence in Best Vitelliform Macular Dystrophy: RPE Lipofuscin is Not Increased in Non-Lesion Areas of Retina.- Interpretation of Flood-Illuminated Adaptive Optics Images in Subjects with Retinitis Pigmentosa.- Intra-familial Similarity of Wide-Field Fundus Autofluorescence in InheritedRetinal Dystrophy.- Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy.- The Development of a Cat Model of Retinal Detachment and Re-Attachment.- Part V Mechanisms of Degeneration.- The Role of X-Chromosome Inactivation in Retinal Development and Disease.- A Non-canonical Role for β-Secretase in the Retina.- The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors.- The Rate of Vitamin A Dimerization in Lipofuscinogenesis, Fundus Autofluorescence, Retinal Senescence and Degeneration.- Can Vitamin A be Improved to Prevent Blindness due to Age-Related Macular Degeneration, Stargardt Disease and Other Retinal Dystrophies?.- Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina.- Cell Cycle Proteins and Retinal Degeneration: Evidences of New Potential Therapeutic Targets.- Neuronal Nitric Oxide Synthase as a Trigger of the N-methyl-N-nitrosourea-induced Photoreceptor Cell Death.- Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases.- Aging and Vision.- Part VI Neuroprotection, Small Molecules & Related Therapeutic Approaches.- The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair.- Retinal Caveolin-1 Modulates Neuroprotective Signaling.- Photoreceptor Neuroprotection: Regulation of Akt activation through Serine/Threonine Phosphatases, PHLPP and PHLPPL.- The Role of AMPK pathway in Neuroprotection.- Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1.- Near-Infrared Photobiomodulation in Retinal Injury and Disease.- Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns.- Small Molecules that Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models.- Histone Deacetylase: Therapeutic Targets in Retinal Degeneration.- Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases.- Transscleral Controlled Delivery of Geranylgeranylaceton Using a Polymeric Device Protects Rat Retina Against Light Injury.- Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa.- Part VII Gene Therapy & Antisense.- Gene Therapy for MERTK-Associated Retinal Degenerations.- Tamoxifen-containing Eye Drops Successfully Trigger Cre-mediated Recombination in the Entire Eye.- Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages.-          Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin.- Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies.- Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins.- Evaluation of Ocular Gene Therapy in an Italian Patient Affected by Congenital Leber Amaurosis Type 2 Treated in Both Eyes.-Part VIII Stem Cells & Cell-based Therapies.- Regenerative Medicine: Solution in Sight.- Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-derived Retinal Pigment Epithelium Cells.- Human Retinal Pigment Epithelium Stem Cell (RPESC).- Embryonic Stem Cell‐Derived Microvesicles: Could They Be Used for Retinal Regeneration?.- Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders.- Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina.- Interkinetic Nuclear Migration in the Regenerating Retina.- Part IX Photoreceptors & Inner Retina.- Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.- A Novel Approach to Identify Photoreceptor Compartment-Specific Tulp1 Binding Partners.- Thyroid Hormone Signaling and Cone Photoreceptor Viability.- In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.- The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium.- Regulation of Retinal Development Via the Epigenetic Modification of Histone.- The Potential Role of Flavins and Retbindin in Retinal Function and Homeostasis.- Identification of Tyrosine O Sulfated Proteins in Cow Retina and the 661W Cell Line.- The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.-Characterization of Antibodies to Identify Cellular Expression of Dopamine.- Receptor 4.- A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.- JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo and After Hypoxia In Vitro.- Cell Fate of Müller Cells During Photoreceptor Regeneration in an MNU-induced Retinal Degeneration Model of Zebrafish.- Polymodal Sensory Integration in Retinal Ganglion Cells.- Pigment Epithelium-derived Factor, a Protective Factor for Photoreceptors In Vivo.- Part X Retinal Pigment Epithelium (RPE).- The mTOR Kinase Inhibitor INK128 Blunts Migration of Cultured Retinal Pigment Epithelial Cells.- Live Imaging of LysoTracker-Labelled Phagolysosomes Tracks Diurnal Phagocytosis of Photoreceptor Outer Segment Fragments in Rat RPE Tissue Ex Vivo.- Cre Recombinase: You Can’t Live with It, and You Can’t Live without It.- Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells.- Contribution of Ion Channels in Calcium Signaling Regulating Phagocytosis: maxiK, Cav1.3 and Bestrophin-1.- Lysosomal Trafficking Regulator (LYST).- Live-cell Imaging of Phagosome Motility in Primary Mouse RPE Cells.- RPE Cell and Sheet Properties in Normal and Diseased Eyes.- Valproic Acid Induced Human Retinal Pigment Epithelial Cell Death as Well as its Survival After Hydrogen Peroxide Damage is Mediated by P38 Kinase.- Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis.- Modulation of V-ATPase by βA3/A1-crystallin in the Retinal Pigment Epithelial Cells.- Proteomic Profiling of Cigarette Smoke Induced Changes in Retinal Pigment Epithelium Cells.- Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress.

“Edited by half a dozen experts, this scientific compendium covers experimental and research topics that happen behind the scenes in the ophthalmology world. … This book is intended for full-time retinal researchers, or clinicians participating in clinical trials who want more insight into retinal research.” (EuroTimes, March, 2017)