Reactive Oxygen Species

Network Pharmacology and Therapeutic Applications

Häftad, Engelska, 2022

Av Harald H. H. W. Schmidt, Pietro Ghezzi, Antonio Cuadrado

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Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants.

Produktinformation

Utgivningsdatum2022-02-24
Mått155 x 235 x 22 mm
Vikt736 g
FormatHäftad
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor425
FörlagSpringer Nature Switzerland AG
ISBN9783030685126

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Kemi inom Naturvetenskap och teknik
Hjärt- och kärlsjukdomar inom Medicin
Biovetenskap inom Naturvetenskap och teknik
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Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine.- Demystifying oxidative stress.- Oxidants in Physiological Processes.- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies.- Part II Targeting antioxidant responses.- Development of Telintra as an Inhibitor of Glutathione S-Transferase P.- Perspectives on the Clinical Development of NRF2-Targeting Drugs.- Part III: Inhibiting ROS formation and toxification.- NOX Inhibitors: From Bench to Naxibs to Bedside.- Nitric Oxide Synthase Inhibitors into the Clinic at Last.- Xanthine Oxidoreductase Inhibitors.- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches.- Inhibition of Myeloperoxidase.- Part IV: Stimulating/substituting ROS.- Effects of Mammalian Thioredoxin Reductase Inhibitors.- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation.- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers.- Part V: Repairing ROS damage.- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander.- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.