Del i serien Handbook of Experimental Pharmacology

Reactive Oxygen Species

Network Pharmacology and Therapeutic Applications

Inbunden, Engelska, 2021

AvHarald H. H. W. Schmidt,Pietro Ghezzi,Antonio Cuadrado

2 849 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt för medlemmar vid köp för minst 249 kr.

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants.

Produktinformation

Utgivningsdatum2021-02-24
Mått155 x 235 x 28 mm
Vikt896 g
FormatInbunden
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor425
FörlagSpringer Nature Switzerland AG
ISBN9783030685096

Tillhör följande kategorier

Kemi inom Naturvetenskap och teknik
Hjärt- och kärlsjukdomar inom Medicin
Biovetenskap inom Naturvetenskap och teknik
Farmakologi inom Medicin

Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine.- Demystifying oxidative stress.- Oxidants in Physiological Processes.- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies.- Part II Targeting antioxidant responses.- Development of Telintra as an Inhibitor of Glutathione S-Transferase P.- Perspectives on the Clinical Development of NRF2-Targeting Drugs.- Part III: Inhibiting ROS formation and toxification.- NOX Inhibitors: From Bench to Naxibs to Bedside.- Nitric Oxide Synthase Inhibitors into the Clinic at Last.- Xanthine Oxidoreductase Inhibitors.- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches.- Inhibition of Myeloperoxidase.- Part IV: Stimulating/substituting ROS.- Effects of Mammalian Thioredoxin Reductase Inhibitors.- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation.- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers.- Part V: Repairing ROS damage.- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander.- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.