Quantum Tunnelling in Enzyme-Catalysed Reactions

Nigel S. Scrutton graduated from King's College University of London before obtaining PhD and ScD degrees at the University of Cambridge. He is currently BBSRC Professorial Fellow and Professor of Enzymology at the University of Manchester. He has a longstanding interest in structural and mechanistic enzymology and has made a number of major contributions to the field of H-tunneling in biological systems. He has also been involved in interdisciplinary research programmes addressing the mechanisms of electron and hydrogen transfer in biology. Rudolf K. Allemann obtained a Dipl. Chem from the ETH in Zurich. He then studied for a PhD at Harvard University and the ETH-Zurich where he obtained Dr. sc. Nat. in 1988. He is currently a Research Professor and head of Chemical Biology at Cardiff University. His research interests focus on the physical and chemical basis of enzyme catalysis and structural and synthetic biology. He has also been involved in the de novo design of peptides that catalyze reactions with enzyme-like characteristics. Recently, he has pioneered the development of biophotonic nanoswitches for the control of protein-DNA and protein-protein interactions.

• The Transition-State Theory Description of Enzyme Catalysis for Classically Activated ReactionsIntroduction to Quantum Behaviour – A PrimerQuantum Catalysis in EnzymesSelected Theoretical Models and Computational Methods for Enzymatic TunnellingKinetic Isotope Effects from Hybrid Classical and Quantum Path Integral ComputationsBeyond Tunnelling Corrections: Full Tunnelling Models for Enzymatic C–H Activation ReactionsQuantum Effects in Enzyme KineticsDirect Methods for the Analysis of Quantum-Mechanical Tunnelling: Dihydrofolate ReductaseProbing Coupled Motions in Enzymatic Hydrogen Tunnelling Reactions: Beyond Temperature-Dependence Studies of Kinetic Isotope EffectsComputational Simulations of Tunnelling Reactions in EnzymesTunnelling does not Contribute Significantly to Enzyme Catalysis, but Studying Temperature Dependence of Isotope Effects is UsefulThe Use of X-ray Crystallography to Study Enzymic H-tunnellingThe Strengths and Weaknesses of Model Reactions for the Assessment of Tunnelling in Enzymic ReactionsLong-Distance Electron Tunnelling in ProteinsProton-Coupled Electron Transfer: The Engine that Drives Radical Transport and Catalysis in Biology

"this book will serve as an important reference for students and practitioners alike.""the authors and especially the editors have done a great service to the field by putting together this collection of chapters."