Quantitative Methods for Precision Medicine

• Utgivningsdatum: 2022-12-26
• Mått: 156 x 234 x 24 mm
• Vikt: 620 g
• Format: Inbunden
• Språk: Engelska
• Serie: Chapman & Hall/CRC Biostatistics Series
• Antal sidor: 290
• Förlag: Taylor & Francis Inc
• ISBN: 9781482219456

• Farmakologi

Rongling Wu develops a transdisciplinary approach for building up multilayer, multiscale and multifunctional bridges that link genotype to phenotype. Dr. Wu asks, answers, and disseminates biologically meaningful questions in the boundaries of statistics, genetics, ecology, and evolution. He invented a statistical method called functional mapping to reveal the genetic architecture of developmental trajectories and incorporated this approach into the context of eco-evo-devo research aimed to unveil the genetic and ecological mechanisms underpinning evolutionary novelties. More recently, Dr. Wu has integrated evolutionary game theory and predator-prey theory through naturally omnipresent allometric scaling law into graph theory to create a new theory – functional game-graph theory. This new theory can unravel the internal workings of complex systems at an unprecedented level of detail by charting and tracing the causal, signed, and weighted roadmap of relationships among high- or even ultrahigh-dimensional variables from any data domains. The second part of this book represents the application of this theory to pharmacogenomic research. Dr. Wu received his PhD in forest genetics at the University of Washington in 1995. He was appointed as Assistant Professor of Statistics at the University of Florida in 2000 and awarded the University Foundation Professorship in 2007. Since 2008, Dr. Wu has been Professor of Public Health Sciences and Statistics, promoted to Distinguished Professor in 2015, and served as Director of the Center of Statistical Genetics at The Pennsylvania State University. Dr. Wu is a Fellow of the American Statistical Association and a Fellow of American Association for the Advancement of Science.Dr. Sang and Ms. Feng are collaborators of this book writing project under the leadership of Dr. Wu. Dr. Sang got his PhD degree at Beijing Forestry University in 2019 and is currently working as Lecturer of Medical Informatics at Nantong University Medical School, China. Ms. Feng is a PhD candidate in computational biology at Beijing Forestry University and going to graduate in 2023. The research interest of both Dr. Sang and Ms. Feng lies in the statistical modeling of computational biology and its applications to a broader area of agriculture, forestry, medicine, and beyond.

"This book, a valuable addition to the Chapman & Hall/CRC Biostatistics Series, caters to researchers and graduate students with an interest in advanced statistical genetics models and methods. The author, distinguished Professor Rongling Wu, leverages his extensive experience in the field to build upon the pioneering research presented in his previous works, Statistical Genetics of Quantitative Traits and Statistical and Computational Pharmacogenomics. This book offers a comprehensive array of statistical models and methods tailored specifically for pharmacogenomic research, equipping practitioners with innovative genetic research tools that contribute significantly to the evolution of precision medicine. . . . offers an in-depth exploration of quantitative methods in precision medicine, with a particular emphasis on pharmacogenomics. The book addresses a wide array of theoretical and practical issues within precision medicine, targeted toward readers with a strong statistical background working in diverse fields such as biology, medicine, bioinformatics, and drug design. Serving as an indispensable resource for those interested in statistical and computational modeling of biological systems, its selfcontained chapters make it ideal for individual study, as a source of graduate-level project topics, or as a reference for professionals seeking to apply statistical and computational modeling to foster innovation."~Arthur Berg, Journal of the American Statistical Association

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