Privileged Scaffolds in Medicinal Chemistry

Dr Carmen Gil is staff scientist at Center for Biological Research of Spanish National Council for Research (CSIC) with a background in Medicinal Chemistry and Pharmacy. She received her Ph.D. from Complutense University of Madrid in 2001. After a postdoctoral appointment at Bonn University (Germany) she joined the CSIC. Her research is oriented to the discovery and development of new small-molecules as innovative target-based drugs and her research areas have been focused on phosphodiesterase and kinase inhibitors as innovative drug candidates for neurodegenerative diseases. She is involved in different projects that apply her background and experience in the development of specific parasite phosphodiesterase and kinase inhibitors in the fight for neglected parasitic diseases. She is author of more than sixty scientific publications, has four active patents in the field and has contributed to several books. University of Notre Dame

• Privileged scaffolds in medicinal chemistry: An introduction;Privileged scaffolds in medicinal chemistry: A computational approach;The beta-Lactam (Azetidin-2-one) as a privileged ring in medicinal chemistry;(Benz)imidazoles;Pyrazoles;Quinolones: Privileged scaffolds in medicinal chemistry;Isoquinolines;Rhodanine;Heterocycles containinf nitrogen and sulfur as potent biologically active scaffolds;Thiirane class of gelatinase inhibitors as a privileged tempate that cross the blood-brain barrier;Coumarins;Xanthones are privileged scaffolds in medicinal chemistry - but are they over privileged?;Natural product scaffolds of value in medicinal chemistry;Ergot alkaloids;Cyclic Peptides as Privileged structures;Spirocycles as privileged structural motifs in medicinal chemistry;

Many of the chapters have a very readable format; the (mainly) heterocycle core structure is presented, physicochemical properties are given, then synthetic routes to such molecules are shown followed by case studies on many actual drugs based on these scaffolds. Such presentation renders this book appealing to heterocycle, natural product, and medicinal chemists and would be extremely useful pedagogically e.g., for teaching to masters and advanced undergraduate-level students or presenting as case studies in group meetings with postgraduate students. This is certainly a book that would be of interest to researchers and as a reference text in university and industry libraries.