A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci, Emeritus Professor of Haematology at University College London, London, UK.Douglas R. Higgs, MD, FRCP, FRS, Professor of Molecular Haematology & Director, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.David Keeling, Consultant in Haemophilia and Thrombosis, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals, Oxford, UK.Atul B. Mehta MA, MD, FRCP, FRC Path, Consultant Haematologist & Clinical Director, RFH Lysosomal Storage Disorders Unit, Royal Free Hospital, London, UK.

• Contributor List viiPreface to the Seventh Edition xPreface to the First Edition xi1 Stem cells and haemopoiesis 1Emma de Pater, Elaine Dzierzak2 Erythropoiesis 11Douglas R Higgs, Noémi Roy, Deborah Hay3 Iron metabolism, iron deficiency and disorders of haem synthesis 21Clara Camaschella, A Victor Hoffbrand, Chaim Hershko4 Iron overload 40Clara Camaschella, A Victor Hoffbrand, Maria Domenica Cappellini5 Megaloblastic anaemia 53A Victor Hoffbrand6 Haemoglobin and the inherited disorders of globin synthesis 72Swee Lay Thein, David Rees7 Sickle cell disease 98Anne Marsh, Elliott P Vichinsky8 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 114Paola Bianchi, Narla Mohandas9 Acquired haemolytic anaemias 138Modupe O Elebute, Rachel Kesse-Adu10 Inherited aplastic anaemia/bone marrow failure syndromes 156Inderjeet S Dokal11 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 174Judith CW Marsh, Austin G Kulasekararaj, Neal S Young, Peter Hillmen12 Red cell immunohaematology 195Geoff Daniels, Marcela Contreras, Shubha Allard13 Clinical blood transfusion 214Shubha Allard, Marcela Contreras14 Phagocytes 246John Mascarenhas, Marina Kremyanskaya, Ronald Hoffman15 Lysosomal storage disorders 270Atul B Mehta, Derralynn A Hughes16 Normal lymphocytes and non-neoplastic lymphocyte disorders 278Paul Moss, Mark Drayson17 The spleen 303Paul Moss18 The molecular basis of haematological malignancies 314Niccolo Bolli, George Vassiliou19 Laboratory diagnosis of haematological neoplasms 332Torsten Haferlach, Barbara J Bain20 Acute myeloid leukaemia 352Alan K Burnett, David Grimwade21 Adult acute lymphoblastic Llukaemia 371Clare J Rowntree, Adele K Fielding22 Childhood acute lymphoblastic leukaemia 384Ajay Vora23 Supportive care in the management of leukaemia 399Eliza Gil, Vanya Gant, Panagiotis Kottaridis24 Chronic myeloid leukaemia 419David TO Yeung, Timothy P Hughes25 The myelodysplastic syndromes 438Kavita Raj, Ghulam J Mufti26 Myeloproliferative neoplasms 474Peter J Campbell, Claire Harrison, Anthony R Green27 Chronic lymphocytic leukaemia and other chronic B-cell disorders 500Emili Montserrat, Peter Hillmen28 T-cell lymphoproliferative disorders 524Pier Luigi Zinzani, Alessandro Broccoli29 Multiple myeloma 537Jesús San-Miguel, Joan Bladé30 Amyloidosis 562Simon DJ Gibbs, Philip N Hawkins31 The classification of lymphomas: updating the WHO classification 575Elias Campo, Stefano A Pileri32 Hodgkin lymphoma 601Piers Blombery, David Linch33 Non-Hodgkin lymphoma: low grade 614William Townsend, Robert Marcus34 Non-Hodgkin lymphoma: high grade 631Jessica Okosun, Kate Cwynarski35 Stem cell transplantation 651Charles Craddock, Ronjon Chakraverty36 Normal haemostasis 676Keith Gomez, John H McVey37 The vascular function of platelets 699Stephen P Watson, Neil V Morgan, Paul Harrison38 Haemophilia and Von Willebrand disease 715Michael A Laffan, K John Pasi39 Rare inherited coagulation disorders 733Flora Peyvandi, Marzia Menegatti40 Acquired coagulation disorders 743Peter W Collins, Jecko Thachil, Cheng-Hock Toh41 Congenital platelet disorders 761Maurizio Margaglione, Paul RJ Ames42 Primary immune thrombocytopenia 773Drew Provan, Adrian C Newland43 Thrombotic thrombocytopenic purpura and haemolytic–uraemic syndrome (congenital and acquired) 783Pier Mannuccio Mannucci, Flora Peyvandi, Roberta Palla44 Heritable thrombophilia 795Trevor Baglin, David Keeling45 Acquired venous thrombosis 809Beverley J Hunt, Henry G Watson46 Antithrombotic agents 820Trevor Baglin, David Keeling47 Management of venous thromboembolism 830Trevor Baglin, David Keeling48 Haematologicalaspectsofsystemicdisease 838A Victor Hoffbrand, Atul B Mehta49 Haematological aspects of tropical diseases 854Imelda Bates, Ivy Ekem50 Neonatal haematology 870Irene Roberts, Subarna Chakravorty51 WHO Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008) 885Index 888

A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci, Emeritus Professor of Haematology at University College London, London, UK.Douglas R. Higgs, MD, FRCP, FRS, Professor of Molecular Haematology & Director, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.David Keeling, Consultant in Haemophilia and Thrombosis, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals, Oxford, UK.Atul B. Mehta MA, MD, FRCP, FRC Path, Consultant Haematologist & Clinical Director, RFH Lysosomal Storage Disorders Unit, Royal Free Hospital, London, UK.

• Contributor List viiPreface to the Seventh Edition xPreface to the First Edition xi1 Stem cells and haemopoiesis 1Emma de Pater, Elaine Dzierzak2 Erythropoiesis 11Douglas R Higgs, Noémi Roy, Deborah Hay3 Iron metabolism, iron deficiency and disorders of haem synthesis 21Clara Camaschella, A Victor Hoffbrand, Chaim Hershko4 Iron overload 40Clara Camaschella, A Victor Hoffbrand, Maria Domenica Cappellini5 Megaloblastic anaemia 53A Victor Hoffbrand6 Haemoglobin and the inherited disorders of globin synthesis 72Swee Lay Thein, David Rees7 Sickle cell disease 98Anne Marsh, Elliott P Vichinsky8 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 114Paola Bianchi, Narla Mohandas9 Acquired haemolytic anaemias 138Modupe O Elebute, Rachel Kesse-Adu10 Inherited aplastic anaemia/bone marrow failure syndromes 156Inderjeet S Dokal11 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 174Judith CW Marsh, Austin G Kulasekararaj, Neal S Young, Peter Hillmen12 Red cell immunohaematology 195Geoff Daniels, Marcela Contreras, Shubha Allard13 Clinical blood transfusion 214Shubha Allard, Marcela Contreras14 Phagocytes 246John Mascarenhas, Marina Kremyanskaya, Ronald Hoffman15 Lysosomal storage disorders 270Atul B Mehta, Derralynn A Hughes16 Normal lymphocytes and non-neoplastic lymphocyte disorders 278Paul Moss, Mark Drayson17 The spleen 303Paul Moss18 The molecular basis of haematological malignancies 314Niccolo Bolli, George Vassiliou19 Laboratory diagnosis of haematological neoplasms 332Torsten Haferlach, Barbara J Bain20 Acute myeloid leukaemia 352Alan K Burnett, David Grimwade21 Adult acute lymphoblastic Llukaemia 371Clare J Rowntree, Adele K Fielding22 Childhood acute lymphoblastic leukaemia 384Ajay Vora23 Supportive care in the management of leukaemia 399Eliza Gil, Vanya Gant, Panagiotis Kottaridis24 Chronic myeloid leukaemia 419David TO Yeung, Timothy P Hughes25 The myelodysplastic syndromes 438Kavita Raj, Ghulam J Mufti26 Myeloproliferative neoplasms 474Peter J Campbell, Claire Harrison, Anthony R Green27 Chronic lymphocytic leukaemia and other chronic B-cell disorders 500Emili Montserrat, Peter Hillmen28 T-cell lymphoproliferative disorders 524Pier Luigi Zinzani, Alessandro Broccoli29 Multiple myeloma 537Jesús San-Miguel, Joan Bladé30 Amyloidosis 562Simon DJ Gibbs, Philip N Hawkins31 The classification of lymphomas: updating the WHO classification 575Elias Campo, Stefano A Pileri32 Hodgkin lymphoma 601Piers Blombery, David Linch33 Non-Hodgkin lymphoma: low grade 614William Townsend, Robert Marcus34 Non-Hodgkin lymphoma: high grade 631Jessica Okosun, Kate Cwynarski35 Stem cell transplantation 651Charles Craddock, Ronjon Chakraverty36 Normal haemostasis 676Keith Gomez, John H McVey37 The vascular function of platelets 699Stephen P Watson, Neil V Morgan, Paul Harrison38 Haemophilia and Von Willebrand disease 715Michael A Laffan, K John Pasi39 Rare inherited coagulation disorders 733Flora Peyvandi, Marzia Menegatti40 Acquired coagulation disorders 743Peter W Collins, Jecko Thachil, Cheng-Hock Toh41 Congenital platelet disorders 761Maurizio Margaglione, Paul RJ Ames42 Primary immune thrombocytopenia 773Drew Provan, Adrian C Newland43 Thrombotic thrombocytopenic purpura and haemolytic–uraemic syndrome (congenital and acquired) 783Pier Mannuccio Mannucci, Flora Peyvandi, Roberta Palla44 Heritable thrombophilia 795Trevor Baglin, David Keeling45 Acquired venous thrombosis 809Beverley J Hunt, Henry G Watson46 Antithrombotic agents 820Trevor Baglin, David Keeling47 Management of venous thromboembolism 830Trevor Baglin, David Keeling48 Haematologicalaspectsofsystemicdisease 838A Victor Hoffbrand, Atul B Mehta49 Haematological aspects of tropical diseases 854Imelda Bates, Ivy Ekem50 Neonatal haematology 870Irene Roberts, Subarna Chakravorty51 WHO Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008) 885Index 888

A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci, Emeritus Professor of Haematology at University College London, London, UK.Douglas R. Higgs, MD, FRCP, FRS, Professor of Molecular Haematology & Director, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.David Keeling, Consultant in Haemophilia and Thrombosis, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals, Oxford, UK.Atul B. Mehta MA, MD, FRCP, FRC Path, Consultant Haematologist & Clinical Director, RFH Lysosomal Storage Disorders Unit, Royal Free Hospital, London, UK.

• Contributor List viiPreface to the Seventh Edition xPreface to the First Edition xi1 Stem cells and haemopoiesis 1Emma de Pater, Elaine Dzierzak2 Erythropoiesis 11Douglas R Higgs, Noémi Roy, Deborah Hay3 Iron metabolism, iron deficiency and disorders of haem synthesis 21Clara Camaschella, A Victor Hoffbrand, Chaim Hershko4 Iron overload 40Clara Camaschella, A Victor Hoffbrand, Maria Domenica Cappellini5 Megaloblastic anaemia 53A Victor Hoffbrand6 Haemoglobin and the inherited disorders of globin synthesis 72Swee Lay Thein, David Rees7 Sickle cell disease 98Anne Marsh, Elliott P Vichinsky8 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 114Paola Bianchi, Narla Mohandas9 Acquired haemolytic anaemias 138Modupe O Elebute, Rachel Kesse-Adu10 Inherited aplastic anaemia/bone marrow failure syndromes 156Inderjeet S Dokal11 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 174Judith CW Marsh, Austin G Kulasekararaj, Neal S Young, Peter Hillmen12 Red cell immunohaematology 195Geoff Daniels, Marcela Contreras, Shubha Allard13 Clinical blood transfusion 214Shubha Allard, Marcela Contreras14 Phagocytes 246John Mascarenhas, Marina Kremyanskaya, Ronald Hoffman15 Lysosomal storage disorders 270Atul B Mehta, Derralynn A Hughes16 Normal lymphocytes and non-neoplastic lymphocyte disorders 278Paul Moss, Mark Drayson17 The spleen 303Paul Moss18 The molecular basis of haematological malignancies 314Niccolo Bolli, George Vassiliou19 Laboratory diagnosis of haematological neoplasms 332Torsten Haferlach, Barbara J Bain20 Acute myeloid leukaemia 352Alan K Burnett, David Grimwade21 Adult acute lymphoblastic Llukaemia 371Clare J Rowntree, Adele K Fielding22 Childhood acute lymphoblastic leukaemia 384Ajay Vora23 Supportive care in the management of leukaemia 399Eliza Gil, Vanya Gant, Panagiotis Kottaridis24 Chronic myeloid leukaemia 419David TO Yeung, Timothy P Hughes25 The myelodysplastic syndromes 438Kavita Raj, Ghulam J Mufti26 Myeloproliferative neoplasms 474Peter J Campbell, Claire Harrison, Anthony R Green27 Chronic lymphocytic leukaemia and other chronic B-cell disorders 500Emili Montserrat, Peter Hillmen28 T-cell lymphoproliferative disorders 524Pier Luigi Zinzani, Alessandro Broccoli29 Multiple myeloma 537Jesús San-Miguel, Joan Bladé30 Amyloidosis 562Simon DJ Gibbs, Philip N Hawkins31 The classification of lymphomas: updating the WHO classification 575Elias Campo, Stefano A Pileri32 Hodgkin lymphoma 601Piers Blombery, David Linch33 Non-Hodgkin lymphoma: low grade 614William Townsend, Robert Marcus34 Non-Hodgkin lymphoma: high grade 631Jessica Okosun, Kate Cwynarski35 Stem cell transplantation 651Charles Craddock, Ronjon Chakraverty36 Normal haemostasis 676Keith Gomez, John H McVey37 The vascular function of platelets 699Stephen P Watson, Neil V Morgan, Paul Harrison38 Haemophilia and Von Willebrand disease 715Michael A Laffan, K John Pasi39 Rare inherited coagulation disorders 733Flora Peyvandi, Marzia Menegatti40 Acquired coagulation disorders 743Peter W Collins, Jecko Thachil, Cheng-Hock Toh41 Congenital platelet disorders 761Maurizio Margaglione, Paul RJ Ames42 Primary immune thrombocytopenia 773Drew Provan, Adrian C Newland43 Thrombotic thrombocytopenic purpura and haemolytic–uraemic syndrome (congenital and acquired) 783Pier Mannuccio Mannucci, Flora Peyvandi, Roberta Palla44 Heritable thrombophilia 795Trevor Baglin, David Keeling45 Acquired venous thrombosis 809Beverley J Hunt, Henry G Watson46 Antithrombotic agents 820Trevor Baglin, David Keeling47 Management of venous thromboembolism 830Trevor Baglin, David Keeling48 Haematologicalaspectsofsystemicdisease 838A Victor Hoffbrand, Atul B Mehta49 Haematological aspects of tropical diseases 854Imelda Bates, Ivy Ekem50 Neonatal haematology 870Irene Roberts, Subarna Chakravorty51 WHO Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008) 885Index 888