A. VICTOR HOFFBRAND, Emeritus Professor of Haematology, University College London, UK. CONTRIBUTING AUTHORS PRATIMA CHOWDARY, Professor of Haemophillia and Haemostasis, University College London; Consultant Haematologist, KD Haemophilia and Thrombosis Centre, Royal Free Hospital, London. GRAHAM COLLINS, Associate Professor of Haematology and Consultant Haematologist, Oxford Cancer and Haematology Centre, Oxford, UK. JUSTIN LOKE, AACR-CRUK Transatlantic Fellow, Dana-Farber Cancer Institute, Boston, USA and University of Birmingham, Birmingham, UK.

• Preface to the Ninth Edition ivAbout the Companion Website v1 Haemopoiesis 12 Erythropoiesis and general aspects of anaemia 113 Hypochromic anaemias 274 Iron overload 425 Megaloblastic anaemias and other macrocytic anaemias 506 Haemolytic anaemias 657 Genetic disorders of haemoglobin 798 The white cells, part 1: granulocytes, monocytes and their benign disorders 999 The white cells, part 2: lymphocytes and their benign disorders 11610 The spleen 13111 The aetiology and genetics of haematological neoplasia 13812 Management of haematological malignancy 15513 Acute myeloid leukaemia 16814 Chronic myeloid leukaemia 18515 Myeloproliferative neoplasms 19416 Myelodysplastic neoplasms 21017 Acute lymphoblastic leukaemia 22218 The chronic lymphocytic leukaemias 23619 Hodgkin lymphoma 24620 Non-Hodgkin lymphomas 1: General aspects 25921 Non-Hodgkin lymphomas 2: Individual diseases 27022 Multiple myeloma and related plasma cell neoplasms 28723 Amyloid 30224 Aplastic anaemia and bone marrow failure syndromes 30925 Haemopoietic stem cell transplantation 32026 Platelets, coagulation and normal haemostasis 33727 Bleeding disorders caused by platelet and vascular abnormalities 35528 Hereditary coagulation disorders 37029 Acquired coagulation disorders and thrombotic microangiopathies 38530 Thrombosis 1: Pathogenesis and diagnosis 39931 Thrombosis 2: Treatment 41732 Haematological changes in systemic diseases 43733 Blood transfusion 45134 Pregnancy and neonatal haematology 465Appendix: 5th edition (2022) of the World Health Organization Classification of Haematolymphoid Tumours 475Index 478

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A. VICTOR HOFFBRAND, Emeritus Professor of Haematology, University College London, UK. CONTRIBUTING AUTHORS PRATIMA CHOWDARY, Professor of Haemophillia and Haemostasis, University College London; Consultant Haematologist, KD Haemophilia and Thrombosis Centre, Royal Free Hospital, London. GRAHAM COLLINS, Associate Professor of Haematology and Consultant Haematologist, Oxford Cancer and Haematology Centre, Oxford, UK. JUSTIN LOKE, AACR-CRUK Transatlantic Fellow, Dana-Farber Cancer Institute, Boston, USA and University of Birmingham, Birmingham, UK.

• Preface to the Ninth Edition ivAbout the Companion Website v1 Haemopoiesis 12 Erythropoiesis and general aspects of anaemia 113 Hypochromic anaemias 274 Iron overload 425 Megaloblastic anaemias and other macrocytic anaemias 506 Haemolytic anaemias 657 Genetic disorders of haemoglobin 798 The white cells, part 1: granulocytes, monocytes and their benign disorders 999 The white cells, part 2: lymphocytes and their benign disorders 11610 The spleen 13111 The aetiology and genetics of haematological neoplasia 13812 Management of haematological malignancy 15513 Acute myeloid leukaemia 16814 Chronic myeloid leukaemia 18515 Myeloproliferative neoplasms 19416 Myelodysplastic neoplasms 21017 Acute lymphoblastic leukaemia 22218 The chronic lymphocytic leukaemias 23619 Hodgkin lymphoma 24620 Non-Hodgkin lymphomas 1: General aspects 25921 Non-Hodgkin lymphomas 2: Individual diseases 27022 Multiple myeloma and related plasma cell neoplasms 28723 Amyloid 30224 Aplastic anaemia and bone marrow failure syndromes 30925 Haemopoietic stem cell transplantation 32026 Platelets, coagulation and normal haemostasis 33727 Bleeding disorders caused by platelet and vascular abnormalities 35528 Hereditary coagulation disorders 37029 Acquired coagulation disorders and thrombotic microangiopathies 38530 Thrombosis 1: Pathogenesis and diagnosis 39931 Thrombosis 2: Treatment 41732 Haematological changes in systemic diseases 43733 Blood transfusion 45134 Pregnancy and neonatal haematology 465Appendix: 5th edition (2022) of the World Health Organization Classification of Haematolymphoid Tumours 475Index 478

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A. VICTOR HOFFBRAND, Emeritus Professor of Haematology, University College London, UK. CONTRIBUTING AUTHORS PRATIMA CHOWDARY, Professor of Haemophillia and Haemostasis, University College London; Consultant Haematologist, KD Haemophilia and Thrombosis Centre, Royal Free Hospital, London. GRAHAM COLLINS, Associate Professor of Haematology and Consultant Haematologist, Oxford Cancer and Haematology Centre, Oxford, UK. JUSTIN LOKE, AACR-CRUK Transatlantic Fellow, Dana-Farber Cancer Institute, Boston, USA and University of Birmingham, Birmingham, UK.

• Preface to the Ninth Edition ivAbout the Companion Website v1 Haemopoiesis 12 Erythropoiesis and general aspects of anaemia 113 Hypochromic anaemias 274 Iron overload 425 Megaloblastic anaemias and other macrocytic anaemias 506 Haemolytic anaemias 657 Genetic disorders of haemoglobin 798 The white cells, part 1: granulocytes, monocytes and their benign disorders 999 The white cells, part 2: lymphocytes and their benign disorders 11610 The spleen 13111 The aetiology and genetics of haematological neoplasia 13812 Management of haematological malignancy 15513 Acute myeloid leukaemia 16814 Chronic myeloid leukaemia 18515 Myeloproliferative neoplasms 19416 Myelodysplastic neoplasms 21017 Acute lymphoblastic leukaemia 22218 The chronic lymphocytic leukaemias 23619 Hodgkin lymphoma 24620 Non-Hodgkin lymphomas 1: General aspects 25921 Non-Hodgkin lymphomas 2: Individual diseases 27022 Multiple myeloma and related plasma cell neoplasms 28723 Amyloid 30224 Aplastic anaemia and bone marrow failure syndromes 30925 Haemopoietic stem cell transplantation 32026 Platelets, coagulation and normal haemostasis 33727 Bleeding disorders caused by platelet and vascular abnormalities 35528 Hereditary coagulation disorders 37029 Acquired coagulation disorders and thrombotic microangiopathies 38530 Thrombosis 1: Pathogenesis and diagnosis 39931 Thrombosis 2: Treatment 41732 Haematological changes in systemic diseases 43733 Blood transfusion 45134 Pregnancy and neonatal haematology 465Appendix: 5th edition (2022) of the World Health Organization Classification of Haematolymphoid Tumours 475Index 478

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