Polymers for Biomedicine

CARMEN SCHOLZ, PhD, is a Professor in the Department of Chemistry at the University of Alabama in Huntsville, where her research concentrates on the synthesis and characterization of biocompatible and biodegradable polymers. She serves on the editorial boards of 3 journals (including Wiley's Polymer International), has published over 70 papers or proceedings, and edited 5 books.

• List of Contributors ixPart I. Pseudo-Peptides, Polyamino acids and Polyoxazolines 1Chapter 1 - Characterization of Polypeptides and Polypeptoides­ –Methods and Challenges 3David Huesmann and Matthias BarzChapter 2- Poly(2-Oxazoline): The structurally Diverse Biocompatibilizing Polymer 31Rodolphe ObeidChapter 3- Poly(2-oxazoline) Polymers – synthesis, characterization and Applications in Development of Therapeutics 51Randall W. Moreadith and Tacey X. ViegasChapter 4- Polypeptoid Polymers: Synthesis, Characterization and Properties 77Brandon A. Chan, Sunting Xuan, Ang Li, Jessica M. Simpson and Donghui ZhangPart II - Advanced Polycondensates 121Chapter 5 - Polyanhydrides: Synthesis and Characterization 123Rohan Ghadi, Eameema Muntimadugu Wahid Khan and Abraham J. DombChapter 6 - New Routes to Tailor-Made Polyesters 149Kazuki Fukushima and Tomoko FujiwaraChapter 7 - Polyphosphoesters: An old biopolymer in a new light 191Kristin N. Bauer, Hisaschi T.C. Tee, Evandro M. Alexandrino and Frederik R. WurmPart III. Cationically Charged Macromolecules 243Chapter 8 - Design and Synthesis of Amphiphilic Vinyl Copolymers with Antimicrobial Activity 245Leanna L. Foster, Masato Mizutani, Yukari Oda, Edmund F. Palermo and Kenichi KurodaChapter 9 - Enhanced Polyethylenimine-Based Delivery of Nucleic Acids 273Jeff Sparks, Tooba Anwer and Khursheed AnwerChapter 10 - Cationic graft copolymers for DNA engineering 297Atsushi Maruyama and Naohiko ShimadaPart IV. Biorelated polymers by Controlled Radical Polymerization 313Chapter 11 - Synthesis of (Bio)degradable Polymers by Controlled/“Living” Radical Polymerization 315Shannon R. Woodruff and Nicolay V. TsarevskyPart V. Polydrugs and Polyprodrugs 355Chapter 12 - Polymerized drugs – a novel approach to controlled release systems 357B. Demirdirek, J. J. Faig, R. Guliyev and K.E.UhrichChapter 13 - Structural design and synthesis of polymer prodrugs 391Petr Chytil, Libor Kostka and Tomáš EtrychPart VI. Biocompatibilization of Surfaces 421Chapter 14 - Polymeric ultrathin films for surface modifications 423Henning MenzelChapter 15 - Surface Functionalization of Biomaterials by Poly(2-oxazoline)s 457Giulia Morgese and Edmondo M. BenettiChapter 16 - Biorelated polymer brushes by surface initiated reversible deactivation radical polymerization 487Rueben Pfukwa, Lebohang Hlalele and Bert KlumpermanPart VII. Self-assembled Structures and Formulations 525Chapter 17 - Synthesis of amphiphilic invertible polymers for biomedical applications 527A.M. Kohut, I.O. Hevus, S.A. Voronov and A.S. VoronovChapter 18 - Bioadhesive Polymers for Drug Delivery 559Eenko Larrañeta and Ryan F. DonnellyINDEX