• 1. Combination therapy of diseases: general concepts Emma Lam and Philip A. Routledge; 2. Combination therapy with antiepileptic drugs: potential advantages and problems Richard H. Mattson; 3. Pharmacogenetic aspects M. C. Walker, M. R. Johnson and Philip N. Patsalos; 4. Pharmacokinetic principles and mechanisms of drug interactions Philip N. Patsalos; 5. Predictability of metabolic antiepileptic drug interactions Edoardo Spina, Emilio Perucca and Rene Levy; 6. Influence of food and drugs on the bioavailability of antiepileptic drugs C. A. Fontes Ribeiro; 7. Interactions between antiepileptic drugs Bernhard Rambeck and Theodor W. May; 8. Interactions between antiepileptic and non-antiepileptic drugs Jerzy Majkowski and Philip N. Patsalos; 9. Pharmacodynamic principles and mechanisms of drug interactions Blaise F. D. Bourgeois; 10. Methods for assessing pharmacodynamic interactions Blaise F. D. Bourgeois; 11. Experimental studies of pharmacodynamic interactions Stanislaw J. Czuczwar; 12. Clinical studies of pharmacodynamic interactions John R. Pollard and Jacqueline French; 13. Clinical studies of pharmacodynamic interactions between antiepileptic agents and other drugs Gaetano Zaccara, Andrea Messori and Massimo Cincotta; 14. Antiepileptic drug interactions in children Olivier Dulac, Elizabeth Rey and Catherine Chiron; 15. Antiepileptic drug interactions in the elderly James C. Cloyd and Jeannine M. Conway; 16. Antiepileptic drug interactions in pregnancy Mark S. Yerby; 17. Antiepileptic drug interactions in handicapped and mentally retarded patients Matti Sillanpaa; 18. Antiepileptic drugs and sex steroids Richard H. Mattson; 19. Antiepileptic drug interactions in patients requiring psychiatric drug treatment Michael R. Trimble and Marco Mula; 20. Antiepileptic drugs in non-epileptic health conditions - possible interactions Jerzy Majkowski; 21. Drug monitoring in combination therapy W. Froscher; 22. Cognitive side-effects due to antiepileptic drug combinations and interactions Albert P. Aldenkamp, Mark de Krom, I. Kotsopoulos and Jan Vermeulen; 23. Selection of drug combinations in clinical practice - current and future perspectives Jerzy Majkowski; 24. Future research - an experimental perspective R. A. Voskuyl, D. M. Jonker and R. H. Lopes da Silva; 25. Future research - a clinical perspective C. A. Fontes Ribeiro.

'The book contains a wealth of information both for everyday practice and for more theoretical aspect. Interactions between AED … covered in great detail. … Why is this book so important? The authors explain it in their foreword. As a substantial proportion of patients with epilepsy will not become seizure free with one drug, combination therapy is necessary and therefore often used.' Official Journal of the European Paediatric Neurology Society