Patient-Derived Xenograft Models of Human Cancer

Inbunden, Engelska, 2017

1 829 kr

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In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed.

Produktinformation

Utgivningsdatum2017-07-21
Mått155 x 235 x 17 mm
Vikt534 g
FormatInbunden
SpråkEngelska
SerieMolecular and Translational Medicine
Antal sidor204
FörlagSpringer International Publishing AG
ISBN9783319558240

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Onkologi inom Medicin

Yuzhuo Wang, PhDDirector, Living Tumor LaboratoryDistinguished Scientist, BC Cancer AgencySenior Scientist, Vancouver Prostate CentreProfessor, University of British Columbia675 West 10th Avenue, Room 3.122Vancouver, BC, Canada V5Z 1L3Dong Lin, PhD, MDResearch Pathologist, Living Tumor LaboratoryPeter W. Gout, PhDScientific Consultant, Living Tumor LaboratoryHonorary Associate Professor, Department of Urologic Sciences, University of British ColumbiaEmeritus Senior Scientist, Department of Experimental Therapeutics, BC Cancer Agency<675 West 10th Avenue, Room 5.108Vancouver, BC, Canada V5Z 1L3

Introduction.- History and Evolution of PDX Cancer Models.- Establishment and Characterization of PDX Models.- Methods of Generating PDX Models.- Fidelity and Stability of PDX Models.- Applications of PDX Models.- Studies of Cancer Heterogeneity.- PDX and Cancer Stem Cells.- Modeling Cancer Metastasis.- Modeling Drug Resistance.- PDX and Biomarker Development.- PDX and Preclinical Drug Screening.- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine.- Epilogue.- Future Perspective.