Targeted Therapies

• Resistance to Targeted Therapies As a Result of Mutation(s) in the Target.- The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies.- Cancer Signaling Network Analysis by Quantitative Mass Spectrometry.- Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications.- Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies.- Mathematical and Computational Models in Cancer.- Somatic Evolution of Acquired Drug Resistance in Cancer.- Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer.- MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways.- Rational Combination of Targeted Agents to Overcome Cancer Cell ResistanceMathematical and Computational Models in Cancer.- Somatic Evolution of Acquired Drug Resistance in Cancer.- Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer.- MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways.- Rational Combination of Targeted Agents to Overcome Cancer Cell ResistanceMathematical and Computational Models in Cancer.- Somatic Evolution of Acquired Drug Resistance in Cancer.- Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer.- MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways.- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance.

From the reviews: "This is an important resource, providing a mechanistic understanding of the signaling event in cancer for developing effective targeted cancer therapies, as well as computational biology and systems theory. ... great value to oncologists and physician-scientists treating patients, and translational scientists ... . even students interested in this field will find it useful. ... an important book for understanding major mechanisms of resistance to targeted cancer therapeutic agents as well as microRNA as a potential therapy capable of targeting multiple cancer signaling pathways." (Omer Iqbal, Doody's Review Service, September, 2011) "The book provides a well-balanced insight into the topic of drug resistance ... . the reader can find a lot of information about the progress and inspiration how to overcome the cancer resistance. The book represents a useful source of knowledge for cell and molecular biologists, geneticists, professionals in bioinformatics, researchers and physicians working in translational oncology." (J. Sedlak, Neoplasma, Issue 6, November-December, 2012)