Omics in Clinical Practice

Dr. Yu Liu is a bioinformatician with special interest in next-gen sequencing and its applications. His specialties are molecular biology, DNA sequence analysis, next-gen sequencing application on gene expression analysis and comparative genomics, and microarray gene expression analysis. He is the director of the Bioinformatics Resource Center at the University of Wisconsin-Madison. He has a master's degree in computer science from the University of Wisconsin-Madison; a master's degree in developmental biology from the Chinese Academy of Science; and PhD in molecular biology from The Ohio State University.

• Introduction. Part 1: Omics and Human Disease. Comparative Mitochondrial Proteomics: Perspective in Human Diseases. Studies of Complex Biological Systems with Applications to Molecular Medicine: The Need to Integrate Transcriptomic and Proteomic Approaches. Next Generation Sequencing in Cancer Research and Clinical Application. Scientific Challenges and Implementation Barriers to Translation of Pharmacogenomics in Clinical Practice. Part 2: Translational and Personalized Medicine. Clinical Proteomics and Omics Clues Useful in Translational Medicine Research. Genomes2Drugs: Identifies Target Proteins and Lead Drugs from Proteome Data. Part 3: Molecular and Genetic Markers. Pitfalls and Limitations in Translation from Biomarker Discovery to Clinical Utility in Predictive and Personalised Medicine. How Bioinformatics Influences Health Informatics: Usage of Biomolecular Sequences, Expression Profiles and Automated Microscopic Image Analyses for Clinical Needs and Public Health. Application of "Omics" to Prion Biomarker Discovery. Part 4: Omics and Pathogens. Insights from Genomics into Bacterial Pathogen Populations. High Throughput Sequencing and Proteomics to Identify Immunogenic Proteins of a New Pathogen: The Dirty Genome Approach. Coronavirus Genomics and Bioinformatics Analysis. Part 5: Companion Diagnostics. Applications of Next-Generation Sequencing Technologies to Diagnostic Virology. Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture. Index.

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