Ocular Transporters and Receptors

Their Role in Drug Delivery

Inbunden, Engelska, 2013

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Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.

Highly focused on ocular transporters
Most up-to-date research compilation
Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Produktinformation

Utgivningsdatum2013-10-31
Mått156 x 234 x undefined mm
Vikt570 g
FormatInbunden
SpråkEngelska
SerieWoodhead Publishing Series in Biomedicine
Antal sidor276
FörlagElsevier Science
ISBN9781907568862

Tillhör följande kategorier

Oftalmologi inom Medicin
Farmakologi inom Medicin

Ashim K. Mitra is Professor and Chair of Pharmaceutical Sciences at the University of Missouri-Kansas City, USA. He was named one of two recipients for the 2007 ARVO/Pfizer Ophthalmics Translational Research Award He is the Vice Provost for Interdisciplinary Research for the University of Missouri-Kansas City, and Director of Translational Research at UMKC School of Medicine. He is also the University of Missouri Curators’ Professor of Pharmacy and UMKC’s Chairman of Pharmaceutical Sciences He is the author and coauthor over 250 research articles, book chapters and review papers. Dr Mitra is the recipient of a number of research awards from the National Institutes of Health, the American Association of Pharmaceutical Scientists, the American Association of Colleges of Pharmacy and numerous pharmaceutical organizations He is the 1999 recipient of the University Trustee’s Faculty Research award from the University of Missouri and 1992 recipient of National Collegiate Inventor of the Year Award from the National Invention Center and the BF Goodrich Corporation He has served as the editor of Ophthalmic Drug Delivery Systems (CRC Press) ,which is currently in its second edition and coeditor of Advanced Drug Delivery Reviews (Wiley).

List of figures and tablesAbout the authorsChapter 1: Eye: anatomy, physiology and barriers to drug deliveryAbstract:1.1 Introduction1.2 Anatomy and physiology of the eye1.3 Barriers to ocular drug delivery1.4 Conclusions1.5 AcknowledgementsChapter 2: Biology of ocular transporters: efflux and influx transporters in the eyeAbstract:2.1 Introduction2.2 SLC transporters2.3 ABC transporters2.4 ConclusionsChapter 3: Characterization of ocular transportersAbstract:3.1 Introduction3.2 Molecular and cellular characterization3.3 Functional characterization of transportersChapter 4: Transporters and receptors in the anterior segment of the eyeAbstract:4.1 Introduction4.2 Transporters and receptors4.3 Anterior chamber influx transporters4.4 Anterior chamber efflux transporters4.5 Anterior chamber receptors4.6 Other miscellaneous anterior chamber receptors4.7 ConclusionsChapter 5: Transporters and receptors in the posterior segment of the eyeAbstract:5.1 Introduction5.2 Influx transporters in posterior segment of the eye5.3 Receptors in posterior segment of the eye5.4 ABC transporters5.5 ConclusionChapter 6: Transporters in drug discovery and delivery: a new paradigm in ocular drug designAbstract:6.1 Introduction6.2 Transporter-targeted drug delivery to the anterior segment6.3 Transporter-targeted drug delivery to the posterior segment6.4 ConclusionChapter 7: Transporter-metabolism interplay in the eyeAbstract:7.1 Introduction7.2 Metabolizing enzymes in ocular tissues7.3 Impact of disease state on the expression of metabolizing enzymes7.4 Efflux transporters and metabolism interplay7.5 Potential impact of the efflux metabolism interplay in ocular bioavailability7.6 Drug design and formulation strategies to overcome the efflux and metabolism interplay7.7 ConclusionIndex

"This is an excellent reference for researchers and scientists interested in ocular drug delivery…It is often a challenge to improve the bioavailability of drugs in various parts of the eye. Successful receptor targeting enhances bioavailability, and this book provides a framework for further research in ocular receptor targeting with the aim of improving bioavailability." Rating: 2 Stars --Doody.com, January 17, 2014