Next-Gen Blood Purification

Silvia De Rosa is an Assistant Professor of Anesthesiology, Intensive Care, and Pain Medicine at the Centre for Medical Sciences (CISMed), University of Trento, Italy. She is also a clinical researcher specializing in Acute Kidney Injury (AKI) and Extracorporeal Organ Support, collaborating with the International Renal Research Institute of Vicenza. Dr. De Rosa serves as the AKI Representative for the Research Committee of the European Society of Intensive Care Medicine (ESICM) and is actively involved in the Italian Society of Anesthesia, Analgesia, and Intensive Care (SIAARTI), where she is Chair and Past Chair of the National Nutrition, Metabolism, and Renal Therapies Section. Her primary research interests include: Acute Kidney Injury (AKI) and Extracorporeal Organ Support; Traumatic Brain Injury (TBI); Clinical Nutrition and Muscle Wasting in Critical Illness; Airway Management in Intensive CareThrough her clinical and academic roles, Dr. De Rosa is dedicated to advancing research in renal therapies, metabolic support, and extracorporeal life support, contributing to the improvement of patient care in intensive care settings. Sergio Lassola is a researcher specializing in respiratory care, with a particular focus on the management of Acute Respiratory Distress Syndrome (ARDS) and respiratory support strategies for critically ill patients, including those affected by COVID-19. His research also extends to blood purification techniques in intensive care, aiming to improve outcomes in patients with acute kidney injury (AKI) and fluid balance disorders.His key research areas include: Management of ARDS and respiratory failure; Respiratory care in COVID-19 patients; Prone positioning in intensive care; Respiratory system compliance and mechanics; Humidification strategies in mechanical ventilation; Extracorporeal blood purification techniques in critical care; Acute Kidney Injury and Fluid Balance in intensive care. Dr. Lassola is actively involved in scientific communication and professional societies. He is a member of the Communication Committee of the Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI), contributing to knowledge dissemination and research development in the field of respiratory and extracorporeal therapies. Through his clinical and research work, he is dedicated to advancing critical care medicine, refining ventilatory and extracorporeal strategies, and improving patient outcomes in intensive care settings.

• 1. Introduction: The Evolution and Future of Blood Purification Technologies.- 2. Core Principles of Blood Purification: Filtration, Adsorption and Bioengineering.- 3. Artificial Intelligence and Personalized Blood Purification.- 4. Advanced Adsorption Technologies and Selective Cytokine Removal.- 5. Sepsis and Cytokine Storm: A New Approach to Extracorporeal Therapy.- 6. Extracorporeal Blood Purification in Infectious Diseases and COVID-19.- 7. Extracorporeal Therapies in Chronic Kidney Disease.- 8. Multi-Organ Extracorporeal Support: ECMO, CRRT, and Liver Support Integration.- 9. Blood Purification in Cardiac Surgery and Transplantation.- 10. Extracorporeal Liver Support (ECLS) Systems.- 11. Extracorporeal CO2 Removal : Techiques and Clinical Applications.- 12. Wearable and Portable Blood Purification Devices.- 13. Nanotechnology for Blood Purification.- 14. Extracorporeal Blood Purification and Cancer Therapy.- 15. Gene Therapy and Blood Purification: A Future Perspective.- 16. The Role of Artificial Organs in Blood Purification.- 17. Ethics, Economics, and Global Access to Blood Purification Technologies.- 18. Regulatory Challenges and Approval Pathways for Next-Generation Blood Purification Devices.- 19. Emerging biotechnologies in blood purification.- 20. Case-Based Applications: Real-World Scenarios in Extracorporeal Therapies.- 21. The future of Blood Purification: What’s the next?.