Endotoxin Induced-Shock: a Multidisciplinary Approach in Critical Care

Silvia De Rosa is Anaesthesiologist and Intensivist at Department of Anaesthesia and Intensive Care, Santa Chiara Regional Hospital, APSS Trento, Italy; Centre for Medical Sciences – CISMed University of Trento, via S. Maria Maddalena, Italy. She is also a clinical researcher in Acute Kidney Injury and  Extracorporeal Organ Support at International Renal Research Institute of Vicenza.  She is a Next Committee Representative of the European Society of Intensive Care Medicine (ESICM) and Regional Councilor of “Italian Society of Anesthesia Analgesia and Intensive Care” (SIAARTI - Veneto Region). Her field of interest are Acute Kidney Injury and Extracorporeal Organ Support, Brain Trauma, Nutrition and Muscle Wasting, Airways Management. Co-investigator of the International registry on Acute Renal Replacement Therapy (Global-ARRT Registry).Gianluca Villa is Associated Professor in Anaesthesiology, Intensive Care and Pain Medicine at the University of Florence. He is alsoa clinical researcher in Acute Kidney Injury and Extracorporeal Organ Support at International Renal Research Institute of Vicenza. Principal investigator of the International registry on Acute Renal Replacement Therapy (Global-ARRT Registry).

• Endotoxin: Structure Source and Effects.- Pathophysiology of Endotoxic Shock.- Host Resistance to Endotoxic Shock.- Endotoxin and Organ Cross-talk.- Endotoxin Measurement in Septic Shock.- Clinical Management of Endotoxemia: Antibiotics.- Clinical Management of endotoxemia: volume support.- Clinical Management of Endotoxemia: Corticosteroids.- Clinical Management of Endotoxemia: Vasoactive and Cardiostimulant Drugs.- Clinical Management of Endotoxemia: Source Control.- Clinical Management of Endotoxemia: Treatment of DIC.- Clinical Management of Endotoxemia: Metabolic and Nutritional Support.- Strategies to Reduce Endotoxin Activities.- Extracorporeal Removal of Endotoxin.