Joanne Lymn is Professor of Healthcare Education at University of Nottingham, UK, and a National Teaching Fellow. Alison Mostyn is Professor of Pharmacology Education for Health and Director of Teaching and Learning, University of Nottingham, UK. Roger Knaggs is Professor of Pain Management at University of Nottingham, UK, and Specialist Pharmacist in Pain Management at Primary Integrated Community Services. He is also President of the British Pain Society. Michael Randall is Professor of Pharmacology at University of Nottingham, UK, and a Fellow of the British Pharmacological Society. Dianne Bowskill is Associate Professor of Prescribing Education and Lead for Non-medical prescribing, University of Nottingham, UK.

• List of Contributors xxviForeword xxviiPreface xxviiiAcknowledgements xxixSection 1 The Patient 1Section Introduction 11 The Consultation 3Frank Coffey and Dianne Bowskill2 Accountability and Prescribing 14Matthew Boyd, Stephanie Bridges, and Helen Boardman3 Prescribing and the Law 23Richard Griffith4 The Ethics of Prescribing 36Matthew Boyd, Stephanie Bridges, and Helen Boardman5 Prescribing in Practice 44Dianne Bowskill and Daniel Shipley6 Public Health Issues 53Michael Watson and Katharine WhittinghamSection 2 Pharmacology 63Section Introduction 657 General Principles of Pharmacology 67Joanne Lymn and Alison Mostyn8 Pharmacokinetics 1: Absorption and Distribution 79Joanne Lymn and Alison Mostyn9 Pharmacokinetics 2: Metabolism and Excretion 92Joanne Lymn and Alison Mostyn10 Routes of Administration 106Joanne Lymn and Roger Knaggs11 Variations in Drug Handling 114Michael Randall12 Polypharmacy and Medicines Optimisation 124Daniel Shipley13 Adverse Drug Reactions and Interactions 134Alison Mostyn and Daniel Shipley14 Introduction to the Autonomic Nervous System 144Joanne Lymn15 Clinical Application of the Principles of the Autonomic Nervous Systems 157Joanne Lymn16 The Gastrointestinal System 167Michael Randall17 Cardiovascular Drugs and Diseases 177Richard Roberts18 Haemostasis and Thrombosis 196Michael Randall19 The Renal System 208Michael Randall20 The Respiratory System 221Richard Roberts21 Introduction to the Central Nervous System 235Yvonne Mbaki22 Neurodegenerative Disorders 245David Kendall23 Depression and Anxiety 256Yvonne Mbaki24 Schizophrenia 267David Kendall25 Epilepsy and Antiseizure Drugs 277Michael F O’Donoghue and Christina Giavasi26 Pain and Analgesia 293Roger Knaggs27 Drugs of Misuse 308Michael Randall28 Antibacterial Chemotherapy 315Tim Hills29 Antibiotic Resistance and Clostridioides Difficile 331Tim Hills30 Antifungal and Antiviral Drugs 342Tim Hills31 The Endocrine System 352Alison Mostyn and Daniel Shipley32 Contraception and Reproductive Health 369Alison Mostyn and Anna Soames33 Cancer Pharmacotherapy 381Michael Randall34 Musculoskeletal Disease 392Sana Awan and David Andrew WalshGlossary 409Activity Answers 417Index 445

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Joanne Lymn is Professor of Healthcare Education at University of Nottingham, UK, and a National Teaching Fellow. Alison Mostyn is Professor of Pharmacology Education for Health and Director of Teaching and Learning, University of Nottingham, UK. Roger Knaggs is Professor of Pain Management at University of Nottingham, UK, and Specialist Pharmacist in Pain Management at Primary Integrated Community Services. He is also President of the British Pain Society. Michael Randall is Professor of Pharmacology at University of Nottingham, UK, and a Fellow of the British Pharmacological Society. Dianne Bowskill is Associate Professor of Prescribing Education and Lead for Non-medical prescribing, University of Nottingham, UK.

• List of Contributors xxviForeword xxviiPreface xxviiiAcknowledgements xxixSection 1 The Patient 1Section Introduction 11 The Consultation 3Frank Coffey and Dianne Bowskill2 Accountability and Prescribing 14Matthew Boyd, Stephanie Bridges, and Helen Boardman3 Prescribing and the Law 23Richard Griffith4 The Ethics of Prescribing 36Matthew Boyd, Stephanie Bridges, and Helen Boardman5 Prescribing in Practice 44Dianne Bowskill and Daniel Shipley6 Public Health Issues 53Michael Watson and Katharine WhittinghamSection 2 Pharmacology 63Section Introduction 657 General Principles of Pharmacology 67Joanne Lymn and Alison Mostyn8 Pharmacokinetics 1: Absorption and Distribution 79Joanne Lymn and Alison Mostyn9 Pharmacokinetics 2: Metabolism and Excretion 92Joanne Lymn and Alison Mostyn10 Routes of Administration 106Joanne Lymn and Roger Knaggs11 Variations in Drug Handling 114Michael Randall12 Polypharmacy and Medicines Optimisation 124Daniel Shipley13 Adverse Drug Reactions and Interactions 134Alison Mostyn and Daniel Shipley14 Introduction to the Autonomic Nervous System 144Joanne Lymn15 Clinical Application of the Principles of the Autonomic Nervous Systems 157Joanne Lymn16 The Gastrointestinal System 167Michael Randall17 Cardiovascular Drugs and Diseases 177Richard Roberts18 Haemostasis and Thrombosis 196Michael Randall19 The Renal System 208Michael Randall20 The Respiratory System 221Richard Roberts21 Introduction to the Central Nervous System 235Yvonne Mbaki22 Neurodegenerative Disorders 245David Kendall23 Depression and Anxiety 256Yvonne Mbaki24 Schizophrenia 267David Kendall25 Epilepsy and Antiseizure Drugs 277Michael F O’Donoghue and Christina Giavasi26 Pain and Analgesia 293Roger Knaggs27 Drugs of Misuse 308Michael Randall28 Antibacterial Chemotherapy 315Tim Hills29 Antibiotic Resistance and Clostridioides Difficile 331Tim Hills30 Antifungal and Antiviral Drugs 342Tim Hills31 The Endocrine System 352Alison Mostyn and Daniel Shipley32 Contraception and Reproductive Health 369Alison Mostyn and Anna Soames33 Cancer Pharmacotherapy 381Michael Randall34 Musculoskeletal Disease 392Sana Awan and David Andrew WalshGlossary 409Activity Answers 417Index 445

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Joanne Lymn is Professor of Healthcare Education at University of Nottingham, UK, and a National Teaching Fellow. Alison Mostyn is Professor of Pharmacology Education for Health and Director of Teaching and Learning, University of Nottingham, UK. Roger Knaggs is Professor of Pain Management at University of Nottingham, UK, and Specialist Pharmacist in Pain Management at Primary Integrated Community Services. He is also President of the British Pain Society. Michael Randall is Professor of Pharmacology at University of Nottingham, UK, and a Fellow of the British Pharmacological Society. Dianne Bowskill is Associate Professor of Prescribing Education and Lead for Non-medical prescribing, University of Nottingham, UK.

• List of Contributors xxviForeword xxviiPreface xxviiiAcknowledgements xxixSection 1 The Patient 1Section Introduction 11 The Consultation 3Frank Coffey and Dianne Bowskill2 Accountability and Prescribing 14Matthew Boyd, Stephanie Bridges, and Helen Boardman3 Prescribing and the Law 23Richard Griffith4 The Ethics of Prescribing 36Matthew Boyd, Stephanie Bridges, and Helen Boardman5 Prescribing in Practice 44Dianne Bowskill and Daniel Shipley6 Public Health Issues 53Michael Watson and Katharine WhittinghamSection 2 Pharmacology 63Section Introduction 657 General Principles of Pharmacology 67Joanne Lymn and Alison Mostyn8 Pharmacokinetics 1: Absorption and Distribution 79Joanne Lymn and Alison Mostyn9 Pharmacokinetics 2: Metabolism and Excretion 92Joanne Lymn and Alison Mostyn10 Routes of Administration 106Joanne Lymn and Roger Knaggs11 Variations in Drug Handling 114Michael Randall12 Polypharmacy and Medicines Optimisation 124Daniel Shipley13 Adverse Drug Reactions and Interactions 134Alison Mostyn and Daniel Shipley14 Introduction to the Autonomic Nervous System 144Joanne Lymn15 Clinical Application of the Principles of the Autonomic Nervous Systems 157Joanne Lymn16 The Gastrointestinal System 167Michael Randall17 Cardiovascular Drugs and Diseases 177Richard Roberts18 Haemostasis and Thrombosis 196Michael Randall19 The Renal System 208Michael Randall20 The Respiratory System 221Richard Roberts21 Introduction to the Central Nervous System 235Yvonne Mbaki22 Neurodegenerative Disorders 245David Kendall23 Depression and Anxiety 256Yvonne Mbaki24 Schizophrenia 267David Kendall25 Epilepsy and Antiseizure Drugs 277Michael F O’Donoghue and Christina Giavasi26 Pain and Analgesia 293Roger Knaggs27 Drugs of Misuse 308Michael Randall28 Antibacterial Chemotherapy 315Tim Hills29 Antibiotic Resistance and Clostridioides Difficile 331Tim Hills30 Antifungal and Antiviral Drugs 342Tim Hills31 The Endocrine System 352Alison Mostyn and Daniel Shipley32 Contraception and Reproductive Health 369Alison Mostyn and Anna Soames33 Cancer Pharmacotherapy 381Michael Randall34 Musculoskeletal Disease 392Sana Awan and David Andrew WalshGlossary 409Activity Answers 417Index 445

Select Guide Rating