Del 0 - Drug Discovery Series

New Horizons in Predictive Drug Metabolism and Pharmacokinetics

Inbunden, Engelska, 2015

AvAlan G E Wilson,USA) Wilson, Alan G E (Lexicon Pharmaceuticals,Alan G. E. Wilson

3 979 kr

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Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk. Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities.Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.

Produktinformation

Utgivningsdatum2015-11-20
Mått156 x 234 x 25 mm
Vikt799 g
FormatInbunden
SpråkEngelska
SerieDrug Discovery Series
Antal sidor422
FörlagRoyal Society of Chemistry
ISBN9781849738286

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Farmakologi inom Medicin

Alan G.E. Wilson is an expert in the area of drug metabolism, pharmacokinetics and toxicology. He is a Board Certified Toxicologist with over thirty years of experience working in governmental and industrial companies, conducting ADME, PK, Toxicology and risk assessments. He has over 120 peer reviewed publications, including edited books and book chapters and is a frequently invited speaker at International Symposia. He is currently Vice President of a Department of DMPK, Toxicology and Pathology.

How physicochemical properties of drugs affect their metabolism and clearance;Role of solubility, permeability and adsorption in drug discovery in development;Models for nonspecific binding and partitioning;Cytochrome P450 mediated drug metabolism;Non-cytochrome P450 enzymes and glucuronidation;Metabolite profiling;Application of humanised and other transgenic models to predict human responses to drugs;Stem cells and drug metabolism;Chemically reactive versus stable drug metabolites: Role in adverse drug reactions;Integrating metabolism and toxicity properties;Metabolomics-based approaches to determine drug metabolite profiles;Drug-drug ineteractions: regulatory and theoretical considerations, and an industrial perspective;Drug-drug interactions: Computational approaches;Induction of hepatic cytochrome P450 enzymes: Importance in drug development and toxicity;Current status and implications of transporters: QSAR analysis method to evaluate drug-drug interactions of human bile salt export pump (ABCB11/BSEP) and prediction of intrahepatic cholestasis risk;Formulation of optimizing bioavailability;Systems pharmacology modelling;Pharmacokinetic-pharmacodynamic modelling in drug development with special reference to oncology;

In the book New Horizons in Predictive Drug Metabolism and Pharmacokinetics, Editor Alan G. E. Wilson has brought together leading experts from industry, academia, and regulatory bodies to deliver a timely overview of experimental and computational methods for the prediction of drug metabolism and pharmacokinetics.Refreshingly, the book highlights many relevant aspects that generally are not discussed in much detail in related literature.Although all chapters can be read as independent stories, studying the book from the beginning to end does have added value. The book is recommended to a broad audience of scientists interested in predictive methods for drug metabolism and pharmacokinetics. For experts, this book will be a valuable reference of the current state of research, and for postgraduate students, it will be a very good resource to obtain a global overview of the field.