Nanotoxicity

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration.Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007), and Toxicogenomics (Wiley, Oct 2008). Professor Daniel A. Casciano, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USAProfessor Casciano was former director of the US Food and Drug Administration's National Center for Toxicological Research in Jefferson, Arkansas, USA.

• Preface xiList of Contributors xiiiAcknowledgments xix1 Characterization of Nanomaterials for Toxicological Evaluation 1Kevin W. Powers, Maria Palazuelos, Scott C. Brown and Stephen M. Roberts2 Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies 29Christie M. Sayes and David B. Warheit3 Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines 41Lea Ann Dailey4 High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm 61Craig A. Poland, Rodger Duffin and Ken Donaldson5 Application of Zinc Oxide Quantum Dots in Food Safety 81Tony Jin, Dazhi Sun, Howard Zhang and Hung-Jue Sue6 Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo 97Jinsong Zhang7 Evaluation of Toxicity of Nanostructures in Biological Systems 115Adam J. Gormley and Hamidreza Ghandehari8 Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials 161David B. Warheit, Kenneth L. Reed and Christie M. Sayes9 Nanoparticles: Is Neurotoxicity a Concern? 171Jianyong Wang, Wenjun Sun and Syed F. Ali10 Hepatotoxic Potential of Nanomaterials 183Saura C. Sahu11 Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets 191Jan Simak12 Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment 227David S. Barber, Nancy D. Denslow, R. Joseph Griffitt and Christopher J. Martyniuk13 Nanotoxicity of Metal Oxide Nanoparticles in Vivo 247Weiyue Feng, Bing Wang and Yuliang Zhao14 In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity 271Ken-ichiro Inoue and Hirohisa Takano15 In Vivo and In Vitro Models for Nanotoxicology Testing 279Rosalba Gornati, Elena Papis, Mario Di Gioacchino, Enrico Sabbioni, Isabella Dalle Donne, Aldo Milzani and Giovanni Bernardini16 In Vitro and In Vivo Toxicity Study of Nanoparticles 303Jayoung Jeong, Wan-Seob Cho, Seung Hee Kim and Myung-Haing Cho17 In Vitro and In Vivo Models for Nanotoxicity Testing 335Kyung O. Yu, Laura K. Braydich-Stolle, David M. Mattie, John J. Schlager and Saber M. Hussain18 In Vitro Models for Nanotoxicity Testing 349Yinfa Ma19 In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles 379Fabian Blank, Peter Gehr and Barbara Rothen-Rutishauser20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms 397Thomas R. Pisanic, Sungho Jin and Veronica I. Shubayev21 Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment 427David Y. Lai and Philip G. Sayre22 Evaluating Strategies For Risk Assessment of Nanomaterials 459Nastassja Lewinski, Huiguang Zhu and Rebekah Drezek23 Strategies for Risk Assessment of Nanomaterials 499Hae-Seong Yoon, Hyun-Kyung Kim, Dong Deuk Jang and Myung-Haing Cho24 Metal Nanoparticle Health Risk Assessment 519Mario Di Gioacchino, Nicola Verna, Rosalba Gornati, Enrico Sabbioni and Giovanni Bernardini25 Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products 543Joyce S. Tsuji, Fionna S. Mowat, Suresh Donthu and Maureen Reitman26 Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials 581Penelope A. Rice, Kimberly S. Cassidy, Jeremy Mihalov and T. Scott ThurmondIndex 597

"I can certainly envisage this book being used widely. Indeed, an excellent and most timely book, clearly written, and sensitively related to nano; above all, it really 'speaks' to the realities of nanotoxicity. An additional bonus.....an important one at that.... Is .the list of references cited at the end of every contribution that must make the acquisition of the volume urgent and imperative." (Current Engineering Practice, 2010)