Molecular Imaging

Dr. Ross is the Director of the Center for Molecular Imaging at the University of Michigan, which provides state-of-the-art imaging services for the research community and offering a broad range of imaging systems (two IVIS bioluminescent/fluorescent imaging systems, an Agilent 7 Tesla horizontal bore MRI system, a Siemens PET/CT, a Trifoil Imaging SPECT/CT, and a Bruker CT system). As part of CMI, his research helps to develop applications for imaging to allow for investigations of cancer growth and response to therapy including noninvasive detection of molecular signaling events in living tissue. Dr. Gambhir served as the Director of the Molecular Imaging Program at Stanford (MIPS) and Canary Center at Stanford for Cancer Early Detection. He has authored over 600 publications, has over 40 patents pending or granted, has been featured on the cover of over 25 journals including the Nature Series, Science, and Science Translational Medicine. He was on the editorial board of several journals including Nano Letters, Nature Clinical Practice Oncology, and Science Translational Medicine. He mentored post-doctoral fellows and graduate students from diverse disciplines. His research focused on the development of imaging assays to monitor fundamental cellular/molecular events in living subjects with an emphasis on the detection and management of cancer. A particular interest of his research and lab was early cancer detection including combining in vivo and in vitro diagnostics.

• Volume 1Overview1. General Principles of Molecular ImagingBrian D. Ross and Sanjiv Sam GambhirPart I: Molecular Imaging Technologies2. Positron Emission TomographyeMagnetic Resonance Imaging Farshad Moradi, Ryan L. Brunsing, Vipul R. Sheth and Andrei Iagaru3. SPECT and SPECT/CTBrian F. Hutton, Marlies C. Goorden and Freek J. Beekman4. Principles of Micro X-ray Computed Tomography Cristian T. Badea5. Small-Animal SPECT, SPECT/CT, and SPECT/MRILing-Jian Meng and Neal H. Clinthorne6. Instrumentation and Methods to Combine Small-Animal PET With Other Imaging Modalities Andrew N. Groll and Craig S. Levin7. Functional Imaging Using Bioluminescent Reporter Genes in Living Subjects Scott K. Lyons, Kevin P. Francis and Christopher H. Contag8. Principles and Practice of Intraoperative Fluorescence Imaging Dimitris Gorpas, Vasilis Ntziachristos and Jie Tian9. Molecular Endoscopic Imaging in CancerTimo Rath, Markus F. Neurath and Raja Atreya10. Intravital Microscopy Shariq M. Usmani and Thorsten R. Mempel11. Ultrasound F. Stuart Foster and Emmanuel Cherin12. Hybrid PET-CT-Ultrasound Imaging Bertrand Tavitian and Mailyn Perez-Liva13. Photoacoustic Molecular Imaging: Principles and Practice Junjie Yao and Lihong V. Wang14. Inhaled Gas Magnetic Resonance Imaging: Advances, Applications, Limitations, and New Frontiers Alexander M. Matheson, Caleb Thompson and Grace Parraga15. Magnetic Particle Imaging for Vascular, Cellular and Molecular Imaging Prashant Chandrasekharan, Zhi Wei Tay, Xinyi Y. Zhou, Elaine Y. Yu, Barry K.L. Fung, Caylin Colson, Benjamin D. Fellows, Yao Lu, Quincy Huynh, Chinmoy Saayujya, Paul Keselman, Daniel Hensley, Kuan Lu, Ryan Orendorff, Justin Konkle, Emine Ulku Saritas, Bo Zheng, Patrick Goodwill and Steven Conolly16. Optogenetics Maria G. Paez Segala and Loren L. Looger17. Imaging Mass Spectrometry Richard R. Drake, Danielle A. Scott and Peggi M. Angel18. CEST (Chemical Exchange Saturation Transfer) MR Molecular Imaging Guanshu Liu and Peter C.M. van Zijl19. Molecular Imaging Using Raman Scattering Stefan Harmsen and Sanjiv Sam Gambhir20. Synchrotron-Based Dynamic Lung Imaging Stephen Dubsky21. Light-Sheet Fluorescence Microscopy for Multiscale Biological Imaging Jae-Byum Chang, Ruixuan Gao and Fei Chen22. Cerenkov Imaging Edwin C. Pratt, Ryo Tamura and Jan Grimm23. Near-Infrared II Optical Imaging Shuqing He and Zhen ChengPart II: Chemistry of Molecular Imaging24. Chemistry of Molecular Imaging: An Overview Silvio Aime, Fabio Travagin, Enzo Terreno and Giovanni B. Giovenzana25. PET RadiochemistryHenry F. VanBrocklin26. SPECT RadiochemistryTheodosia Maina and Mathew Thakur27. The Chemistry in Surface Functionalization of Nanoparticles for Molecular Imaging 493Xianchuang Zheng, Joanna Wang and Jianghong Rao28. Newer Bioconjugation Methods Ahmet Krasniqi, Catarina Xavier and Nick Devoogdt29. Targeted Antibodies and Peptides Michael R. Lewis, Cathy S. Cutler and Silvia S. Jurisson30. Antibody-Based Molecular Imaging Kathryn M. Tully, Veronica L. Nagle, Joshua A. Korsen and Jason S. Lewis31. Hyperpolarized Magnetic Resonance With Dissolution Dynamic Nuclear Polarization: Principles and ApplicationsJan H. Ardenkjaer-Larsen32. Magnetic Resonance Imaging AgentsCuihua Wang, Elisenda Rodriguez and John W. Chen33. Optical Imaging AgentsLuisa Ottobrini, Cristina Martelli and Giovanni Lucignani34. Photoacoustic Molecular Imaging With Exogenous AgentsLiming Nie, Yajing Liu and Xiaogyuan Chen35. Ultrasound Contrast AgentsMark A. Borden, Paul A. Dayton, Connor Slagle and Rachel W. Walmer36. Theranostics: Agents for Diagnosis and TherapyFay Nicolson and Moritz F. Kircher37. Magnetic NanoparticlesAhmad Amirshaghaghi, Zhiliang Cheng, Lee Josephson and Andrew Tsourkas38. Aptamers for Molecular Imaging Fre´de´ric Duconge´39. Nonclinical Product Developmental Strategies, Safety Considerations and Toxicity Profiles of Medical Imaging and Radiopharmaceuticals ProductsAdebayo Laniyonu, Yanli Ouyang, Jonathan Cohen, Sunny Awe, Olayinka Dina, Siham Biade, Sally Hargus and Tushar Kokate40. Intraoperative Molecular Imaging Agents Stan van Keulen and Eben L. RosenthalVolume 2Part III: Molecular Imaging in Cell and Molecular Biology41. Protein Engineering for Molecular ImagingAnna M. Wu42. Phage Display for Imaging Agent Development Jessica Hung, Fred Reynolds and Kimberly A. Kelly43. Molecular Imaging of Gene Therapy Ramasamy Paulmurugan and Tarik F. Massoud44. Cell Surveillance Using Magnetic Resonance ImagingBrooke M. Helfer and Jeff W.M. Bulte45. Tumor Vasculature Susan Notohamiprodjo, Zohreh Varasteh, Ambros J. Beer, Gang Niu, Xiaoyuan (Shawn) Chen, Wolfgang Weber and Markus Schwaiger46. Imaging HypoxiaHong Yuan, Gregory M. Palmer and Mark W. Dewhirst47. Molecular Imaging of ProteineProtein Interactions and Protein FoldingTarik F. Massoud and Ramasamy Paulmurugan48. Molecular Imaging of Cellular Signaling PathwaysKathryn E. Luker49. Exosome Imaging Do Won Hwang, Minseok Suh and Dong Soo Lee50. Gene-Editing Technologies and Applications for Molecular Imaging Gary D. Luker51. Reporter Genes for Ultrasound and MRI Mikhail G. Shapiro52. Theranostic Approaches Using Live Bacteria Jung-Joon Min, Mai Thi-Quynh Duong, Thangam Ramar, Sung-Hwan You and Sae-Ryung KangPart IV: Applications of Molecular Imaging Oncology53. Molecular and Functional Imaging and Theranostics of the Tumor Microenvironment Marie-France Penet, Samata Kakkad, Jesus Pacheco-Torres, Santosh Bharti, Balaji Krishnamachary and Zaver M. Bhujwalla54. Novel Magnetic Resonance Imaging and Positron Emission Tomography in the RT Planning and Assessment of Response of Malignant Gliomas David Kamson and Christina Tsien55. PET Diagnosis and Response Monitoring in Oncology Richard L. Wahl and Rodney J. Hicks56. Spectroscopic MRI for Brain Tumor Imaging Hyunsuk Shim57. Cancer Detection and Quantification of Treatment Response Using Diffusion-Weighted MRI Brian D. Ross and Thomas L. Chenevert58. Prostate Cancer Theranostics Steven P. Rowe, Mohammad S. Sadaghiani, Rudolf A. Werner, Takahiro Higuchi, Thorsten Derlin, Lilja B. Solnes and Martin G. Pomper59. Pediatric Molecular Imaging Heike E. Daldrup-LinkCardiovascular60. Imaging Myocardial Metabolism Robert J. Gropler61. Congestive Heart Failure Stephan G. Nekolla, Antti Saraste, Hendrik Sager, Marcus R. Makowski and Markus Schwaiger62. Molecular Imaging of Atherosclerosis Eric A. Osborn, Mazen Albaghdadi, Peter Libby and Farouc A. Jaffer63. Thrombosis and Embolism Reza Hajhosseiny, Claudia Prieto, Haikun Qi, Alkystis Phinikaridou and Rene´ M. Botnar64. Molecular Imaging of Stem Cell Therapy in Ischemic Cardiomyopathy Mark Chandy and Joseph C. WuCentral Nervous System65. Central Nervous System Molecular Imaging Lilja B. Solnes, Andreas H. Jacobs, Jennifer M. Coughlin, Yong Du, Reema Goel, Dima A. Hammoud and Martin G. Pomper66. Applications, Advances, and Limitations of Molecular Imaging of Brain Receptors Paul Cumming, Gerhard Gru¨nder, Zabecca Brinson and Dean F. Wong67. PET and SPECT Imaging of Neurodegenerative Diseases Alexander Drzezga, Ge´rard N. Bischof, Kathrin Giehl and Thilo van Eimeren68. PET Imaging of Neuroinflammation Aisling M. Chaney, Emily M. Deal, Isaac M. Jackson and Michelle L. JamesAutoimmunity and Immunology69. Identifying Musculoskeletal Pain Generators Using Molecular Imaging Daehyun Yoon, Feliks Kogan, Garry Gold and Sandip Biswal70. Molecular Imaging of Autoimmune Diseases Alberto Signore, Arianna Di Paolo and Filippo Galli71. Molecular Imaging of Diabetes Lieke Joosten, Marti Boss, Tom Jansen, Maarten Brom, Mijke Buitinga, Erik Aarntzen, Olof Eriksson, Lars Johansson, Bastiaan de Galan and Martin Gotthardt72. Imaging in Asthma Avanti Gulhane and Delphine L. Chen73. Molecular Imaging of Fibrosis Iris Y. Zhou, Sydney B. Montesi, Eman A. Akam and Peter Caravan74. Imaging of Bacterial Infections Alvaro A. Ordon˜ez and Sanjay K. JainPart V: Molecular Imaging in Drug Evaluation75. Molecular and Functional Imaging in Central Nervous System Drug Development Basil Ku¨nnecke, Michael Honer, Gennaro Pagano and Markus Rudin76. PET Imaging in Cancer Clinical Trials David A. Mankoff77. Magnetic Resonance Imaging: Cardiovascular Applications for Clinical Trials Chun Yuan, Zach Miller and Xue-Qiao Zhao78. Imaging of Gene and Cell-Based Therapies: Basis and Clinical Trials Andreas H. Jacobs, Sonja Schelhaas, Thomas Viel, Yannic Waerzeggers, Alexandra Winkeler, Bastian Zinnhardt and Juri GelovaniPart VI: Image Quantitation/Analytics79. Virtual and Augmented Reality Technologies in Molecular and Anatomical Imaging Suman B. Mondal and Samuel Achilefu80. Quantification of Radiotracer Uptake Into Tissue Michael M. Graham81. Pharmacokinetic Modeling Sung-Cheng (Henry) Huang82. Online Social Media: Concepts and Practices for Molecular Imaging Professionals Chadwick L. Wright, Michelle I. Knopp and Michael V. Knopp83. The Regulatory Process for Imaging Agents and Devices Matthew F. Covington, Sally W. Schwarz and John M. Hoffman84. Operational Radiation Safety for PET-CT, SPECT-CT, and Cyclotron Facilities Pat Zanzonico85. Bridging Spatial Scales From Radiographic Images to Cellular and Molecular Properties in Cancers Natarajan Raghunand and Robert A. Gatenby86. AI/Machine Learning in Medical Imaging Maryellen L. Giger87. Retrospective Registration in Molecular Imaging Brian D. Ross, Thomas L. Chenevert and Charles R. Meyer88. Image Processing Analytics: Enhancements and Segmentation Lubomir Hadjiiski, Ravi Samala and Heang-Ping Chan89. Magnetic Resonance Fingerprinting: Basic Concepts and Applications in Molecular Imaging Kathleen Ropella-Panagis and Nicole Seiberlich90. MR Elastography Patrick J. Navin, Sudhakar Kundapur Venkatesh and Richard L. Ehman