Modern Methods of Drug Discovery

Häftad, Engelska, 2012

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As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Produktinformation

Utgivningsdatum2012-10-30
Mått155 x 235 x 17 mm
Vikt470 g
FormatHäftad
SpråkEngelska
SerieExperientia Supplementum
Antal sidor292
FörlagSpringer Basel
ISBN9783034893978

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Kemi inom Naturvetenskap och teknik
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1 Modern methods of drug discovery: An introduction.- 2 Proteomics.- 3 Bioinformatics.- 4 High-throughput screening technologies.- 5 Natural products for lead identification: Nature is a valuable resource for providing tools.- 6 Combinatorial chemistry: Mixture-based combinatorial libraries of acyclic and heterocyclic compounds from amino acids and short peptides.- 7 Computational approaches towards the quantification of molecular diversity and design of compound libraries.- 8 The role of protein 3D-structures in the drug discovery process.- 9 NMR-based screening methods for lead discovery.- 10 Structure-based design of combinatorial libraries.- 11 3D QSAR in modern drug design.- 12 Physicochemical concepts in drug design.- 13 Computer-aided prediction of drug toxicity and metabolism.