• SECTION I Introduction1. The Scope of Modern Anesthetic Practice2. Anesthesia and Global Health Equity3. Perioperative Medicine4. Informatics in Perioperative Medicine5. Quality Improvement in Anesthesia Practice and Patient Safety6. Human Behavior and Simulation in Anesthesia7. Ethical Aspects of Anesthesia CareSECTION II Anesthetic Physiology8. Consciousness, Memory, and Anesthesia9. Sleep Medicine10. Cerebral Physiology and the Effects of Anesthetic Drugs11. Neuromuscular Physiology and Pharmacology12. Respiratory Physiology and Pathophysiology13. Cardiac Physiology14. Gastrointestinal and Hepatic Physiology, Pathophysiology, and Anesthetic Considerations15. Renal Anatomy, Physiology, Pharmacology, and Evaluation of Function16. Basic Principles of Pharmacology17. Inhaled Anesthetics: Mechanisms of Action18. Inhaled Anesthetic Uptake, Distribution, Metabolism, and Toxicity19. Pulmonary Pharmacology of Inhaled Anesthetics20. Inhaled Anesthetic Delivery Systems21. Intravenous Anesthetics22. Opioids23. Intravenous Drug Delivery Systems24. Pharmacology of Neuromuscular Blocking Drugs and Antagonists (Reversal Agents)25. Local Anesthetics26. Immune Implications of Anesthesia Care and PracticeSECTION III Anesthesia Management27. Risk of Anesthesia28. Preoperative Evaluation29. Anesthetic Implications of Concurrent Diseases30. Patient Positioning and Associated Risks31. Neuromuscular Disorders and Other Genetic Disorders32. Cardiovascular Monitoring33. Perioperative Echocardiography and Point-of-Care Ultrasound (POCUS)34. Implantable Cardiac Pulse Generators: Pacemakers and Cardioverter-Defibrillators35. Neurophysiologic Monitoring36. Monitoring the Brain’s Response to Anesthesia and Surgery37. Respiratory Monitoring38. Renal Pathophysiology and Treatment for Perioperative Ischemia and Nephrotoxic Injury39. Neuromuscular Monitoring40. Airway Management in the Adult41. Spinal, Epidural, and Caudal Anesthesia42. Peripheral Nerve Blocks and Ultrasound Guidance for Regional Anesthesia43. Perioperative Fluid and Electrolyte Therapy44. Perioperative Acid-Base Balance45. Patient Blood Management: Transfusion Therapy46. Patient Blood Management: CoagulationVOLUME 2SECTION IV Adult Subspecialty Management47. Management of the Patient with Chronic Pain48. Palliative Medicine49. Anesthesia for Thoracic Surgery50. Anesthesia for Cardiac Surgical Procedures51. Anesthesia for Correction of Cardiac Arrhythmias52. Anesthesia for Vascular Surgery53. Anesthesia for Neurologic Surgery and Neurointerventions54. Anesthesia for Bariatric Surgery55. Anesthesia and the Renal and Genitourinary Systems56. Anesthesia for Abdominal Organ Transplantation57. Anesthesia for Organ Procurement58. Anesthesia for Obstetrics59. Anesthesia for Fetal Surgery and Other Fetal Therapies60. Anesthesia for Orthopedic Surgery61. Geriatric Anesthesia62. Anesthesia for Trauma63. Prehospital Care for Medical Emergencies and Trauma64. Biologic, Natural, and Human-Induced Disasters: The Role of the Anesthesiologist65. Anesthesia for Ophthalmic Surgery66. Anesthesia for Otolaryngologic and Head-Neck Surgery67. Anesthesia for Robotic Surgery68. Ambulatory (Outpatient) Anesthesia69. Non-Operating Room Anesthesia70. Clinical Care in Extreme Environments: Physiology at High Altitude and in Space71. Clinical Care in Extreme Environments: High Pressure, Immersion, Drowning, Hypo-, and HyperthermiaSECTION V Pediatric Anesthesia72. Pediatric Anesthesia73. Anesthesia for Pediatric Cardiac Surgery74. Regional Anesthesia in Children75. Pediatric and Neonatal Critical CareSECTION VI Postoperative Care76. The Postanesthesia Care Unit77. Acute Postoperative Pain78. Perioperative Neurocognitive DisordersSECTION VII Critical Care Medicine79. Critical Care Anesthesiology80. Neurocritical Care81. Extracorporeal Membrane Oxygenation and Cardiac Devices82. Cardiopulmonary Resuscitation and Advanced Cardiac Life SupportSECTION VIII Ancillary Responsibilities and Problems83. Burn Management84. Occupational Safety, Infection Control, and Substance Use Disorders85. Emergency Preparedness in Health Care86. Clinical Research87. Interpreting the Medical Literature

"Spanning 2740 pages across two weighty volumes, the textbook is literally and figuratively substantial. For those who want to spare their backs (or bookshelves), a digital version is available through Elsevier’s eBooks+ platform, offering features such as customisable layouts, annotation tools, and integrated videos on clinical techniques, including airway management, echocardiography, and ultrasound-guided procedures.... The format of Miller’s Anesthesia makes it ideal as a comprehensive study resource or reference text for in-depth reading, rather than a quick-access guide in the operating theatre. In that sense, it remains an important publication, particularly valuable for residents and practitioners in North America.... Ultimately, the 10th edition reaffirms Miller’s Anesthesia as an authoritative and expertly edited resource. It remains the gold standard reference for anaesthesia in North America." Review by Andrew F. Cumpstey, Jaideep J. Pandit and Eoin M. Kelleher, British Journal of Anaesthesia, September 2025"The quintessential book for learning the science and practice of anesthesiology and has for years been the standard bearer for resident house staff and attending anesthesiologists." ©Doody’s Review Service, 2025, Joshua E. Insler, MD (Yale School of Medicine)

• SECTION I Introduction1. The Scope of Modern Anesthetic Practice2. Anesthesia and Global Health Equity3. Perioperative Medicine4. Informatics in Perioperative Medicine5. Quality Improvement in Anesthesia Practice and Patient Safety6. Human Behavior and Simulation in Anesthesia7. Ethical Aspects of Anesthesia CareSECTION II Anesthetic Physiology8. Consciousness, Memory, and Anesthesia9. Sleep Medicine10. Cerebral Physiology and the Effects of Anesthetic Drugs11. Neuromuscular Physiology and Pharmacology12. Respiratory Physiology and Pathophysiology13. Cardiac Physiology14. Gastrointestinal and Hepatic Physiology, Pathophysiology, and Anesthetic Considerations15. Renal Anatomy, Physiology, Pharmacology, and Evaluation of Function16. Basic Principles of Pharmacology17. Inhaled Anesthetics: Mechanisms of Action18. Inhaled Anesthetic Uptake, Distribution, Metabolism, and Toxicity19. Pulmonary Pharmacology of Inhaled Anesthetics20. Inhaled Anesthetic Delivery Systems21. Intravenous Anesthetics22. Opioids23. Intravenous Drug Delivery Systems24. Pharmacology of Neuromuscular Blocking Drugs and Antagonists (Reversal Agents)25. Local Anesthetics26. Immune Implications of Anesthesia Care and PracticeSECTION III Anesthesia Management27. Risk of Anesthesia28. Preoperative Evaluation29. Anesthetic Implications of Concurrent Diseases30. Patient Positioning and Associated Risks31. Neuromuscular Disorders and Other Genetic Disorders32. Cardiovascular Monitoring33. Perioperative Echocardiography and Point-of-Care Ultrasound (POCUS)34. Implantable Cardiac Pulse Generators: Pacemakers and Cardioverter-Defibrillators35. Neurophysiologic Monitoring36. Monitoring the Brain’s Response to Anesthesia and Surgery37. Respiratory Monitoring38. Renal Pathophysiology and Treatment for Perioperative Ischemia and Nephrotoxic Injury39. Neuromuscular Monitoring40. Airway Management in the Adult41. Spinal, Epidural, and Caudal Anesthesia42. Peripheral Nerve Blocks and Ultrasound Guidance for Regional Anesthesia43. Perioperative Fluid and Electrolyte Therapy44. Perioperative Acid-Base Balance45. Patient Blood Management: Transfusion Therapy46. Patient Blood Management: CoagulationVOLUME 2SECTION IV Adult Subspecialty Management47. Management of the Patient with Chronic Pain48. Palliative Medicine49. Anesthesia for Thoracic Surgery50. Anesthesia for Cardiac Surgical Procedures51. Anesthesia for Correction of Cardiac Arrhythmias52. Anesthesia for Vascular Surgery53. Anesthesia for Neurologic Surgery and Neurointerventions54. Anesthesia for Bariatric Surgery55. Anesthesia and the Renal and Genitourinary Systems56. Anesthesia for Abdominal Organ Transplantation57. Anesthesia for Organ Procurement58. Anesthesia for Obstetrics59. Anesthesia for Fetal Surgery and Other Fetal Therapies60. Anesthesia for Orthopedic Surgery61. Geriatric Anesthesia62. Anesthesia for Trauma63. Prehospital Care for Medical Emergencies and Trauma64. Biologic, Natural, and Human-Induced Disasters: The Role of the Anesthesiologist65. Anesthesia for Ophthalmic Surgery66. Anesthesia for Otolaryngologic and Head-Neck Surgery67. Anesthesia for Robotic Surgery68. Ambulatory (Outpatient) Anesthesia69. Non-Operating Room Anesthesia70. Clinical Care in Extreme Environments: Physiology at High Altitude and in Space71. Clinical Care in Extreme Environments: High Pressure, Immersion, Drowning, Hypo-, and HyperthermiaSECTION V Pediatric Anesthesia72. Pediatric Anesthesia73. Anesthesia for Pediatric Cardiac Surgery74. Regional Anesthesia in Children75. Pediatric and Neonatal Critical CareSECTION VI Postoperative Care76. The Postanesthesia Care Unit77. Acute Postoperative Pain78. Perioperative Neurocognitive DisordersSECTION VII Critical Care Medicine79. Critical Care Anesthesiology80. Neurocritical Care81. Extracorporeal Membrane Oxygenation and Cardiac Devices82. Cardiopulmonary Resuscitation and Advanced Cardiac Life SupportSECTION VIII Ancillary Responsibilities and Problems83. Burn Management84. Occupational Safety, Infection Control, and Substance Use Disorders85. Emergency Preparedness in Health Care86. Clinical Research87. Interpreting the Medical Literature

"Spanning 2740 pages across two weighty volumes, the textbook is literally and figuratively substantial. For those who want to spare their backs (or bookshelves), a digital version is available through Elsevier’s eBooks+ platform, offering features such as customisable layouts, annotation tools, and integrated videos on clinical techniques, including airway management, echocardiography, and ultrasound-guided procedures.... The format of Miller’s Anesthesia makes it ideal as a comprehensive study resource or reference text for in-depth reading, rather than a quick-access guide in the operating theatre. In that sense, it remains an important publication, particularly valuable for residents and practitioners in North America.... Ultimately, the 10th edition reaffirms Miller’s Anesthesia as an authoritative and expertly edited resource. It remains the gold standard reference for anaesthesia in North America." Review by Andrew F. Cumpstey, Jaideep J. Pandit and Eoin M. Kelleher, British Journal of Anaesthesia, September 2025"The quintessential book for learning the science and practice of anesthesiology and has for years been the standard bearer for resident house staff and attending anesthesiologists." ©Doody’s Review Service, 2025, Joshua E. Insler, MD (Yale School of Medicine)

• SECTION I Introduction1. The Scope of Modern Anesthetic Practice2. Anesthesia and Global Health Equity3. Perioperative Medicine4. Informatics in Perioperative Medicine5. Quality Improvement in Anesthesia Practice and Patient Safety6. Human Behavior and Simulation in Anesthesia7. Ethical Aspects of Anesthesia CareSECTION II Anesthetic Physiology8. Consciousness, Memory, and Anesthesia9. Sleep Medicine10. Cerebral Physiology and the Effects of Anesthetic Drugs11. Neuromuscular Physiology and Pharmacology12. Respiratory Physiology and Pathophysiology13. Cardiac Physiology14. Gastrointestinal and Hepatic Physiology, Pathophysiology, and Anesthetic Considerations15. Renal Anatomy, Physiology, Pharmacology, and Evaluation of Function16. Basic Principles of Pharmacology17. Inhaled Anesthetics: Mechanisms of Action18. Inhaled Anesthetic Uptake, Distribution, Metabolism, and Toxicity19. Pulmonary Pharmacology of Inhaled Anesthetics20. Inhaled Anesthetic Delivery Systems21. Intravenous Anesthetics22. Opioids23. Intravenous Drug Delivery Systems24. Pharmacology of Neuromuscular Blocking Drugs and Antagonists (Reversal Agents)25. Local Anesthetics26. Immune Implications of Anesthesia Care and PracticeSECTION III Anesthesia Management27. Risk of Anesthesia28. Preoperative Evaluation29. Anesthetic Implications of Concurrent Diseases30. Patient Positioning and Associated Risks31. Neuromuscular Disorders and Other Genetic Disorders32. Cardiovascular Monitoring33. Perioperative Echocardiography and Point-of-Care Ultrasound (POCUS)34. Implantable Cardiac Pulse Generators: Pacemakers and Cardioverter-Defibrillators35. Neurophysiologic Monitoring36. Monitoring the Brain’s Response to Anesthesia and Surgery37. Respiratory Monitoring38. Renal Pathophysiology and Treatment for Perioperative Ischemia and Nephrotoxic Injury39. Neuromuscular Monitoring40. Airway Management in the Adult41. Spinal, Epidural, and Caudal Anesthesia42. Peripheral Nerve Blocks and Ultrasound Guidance for Regional Anesthesia43. Perioperative Fluid and Electrolyte Therapy44. Perioperative Acid-Base Balance45. Patient Blood Management: Transfusion Therapy46. Patient Blood Management: CoagulationVOLUME 2SECTION IV Adult Subspecialty Management47. Management of the Patient with Chronic Pain48. Palliative Medicine49. Anesthesia for Thoracic Surgery50. Anesthesia for Cardiac Surgical Procedures51. Anesthesia for Correction of Cardiac Arrhythmias52. Anesthesia for Vascular Surgery53. Anesthesia for Neurologic Surgery and Neurointerventions54. Anesthesia for Bariatric Surgery55. Anesthesia and the Renal and Genitourinary Systems56. Anesthesia for Abdominal Organ Transplantation57. Anesthesia for Organ Procurement58. Anesthesia for Obstetrics59. Anesthesia for Fetal Surgery and Other Fetal Therapies60. Anesthesia for Orthopedic Surgery61. Geriatric Anesthesia62. Anesthesia for Trauma63. Prehospital Care for Medical Emergencies and Trauma64. Biologic, Natural, and Human-Induced Disasters: The Role of the Anesthesiologist65. Anesthesia for Ophthalmic Surgery66. Anesthesia for Otolaryngologic and Head-Neck Surgery67. Anesthesia for Robotic Surgery68. Ambulatory (Outpatient) Anesthesia69. Non-Operating Room Anesthesia70. Clinical Care in Extreme Environments: Physiology at High Altitude and in Space71. Clinical Care in Extreme Environments: High Pressure, Immersion, Drowning, Hypo-, and HyperthermiaSECTION V Pediatric Anesthesia72. Pediatric Anesthesia73. Anesthesia for Pediatric Cardiac Surgery74. Regional Anesthesia in Children75. Pediatric and Neonatal Critical CareSECTION VI Postoperative Care76. The Postanesthesia Care Unit77. Acute Postoperative Pain78. Perioperative Neurocognitive DisordersSECTION VII Critical Care Medicine79. Critical Care Anesthesiology80. Neurocritical Care81. Extracorporeal Membrane Oxygenation and Cardiac Devices82. Cardiopulmonary Resuscitation and Advanced Cardiac Life SupportSECTION VIII Ancillary Responsibilities and Problems83. Burn Management84. Occupational Safety, Infection Control, and Substance Use Disorders85. Emergency Preparedness in Health Care86. Clinical Research87. Interpreting the Medical Literature

"Spanning 2740 pages across two weighty volumes, the textbook is literally and figuratively substantial. For those who want to spare their backs (or bookshelves), a digital version is available through Elsevier’s eBooks+ platform, offering features such as customisable layouts, annotation tools, and integrated videos on clinical techniques, including airway management, echocardiography, and ultrasound-guided procedures.... The format of Miller’s Anesthesia makes it ideal as a comprehensive study resource or reference text for in-depth reading, rather than a quick-access guide in the operating theatre. In that sense, it remains an important publication, particularly valuable for residents and practitioners in North America.... Ultimately, the 10th edition reaffirms Miller’s Anesthesia as an authoritative and expertly edited resource. It remains the gold standard reference for anaesthesia in North America." Review by Andrew F. Cumpstey, Jaideep J. Pandit and Eoin M. Kelleher, British Journal of Anaesthesia, September 2025"The quintessential book for learning the science and practice of anesthesiology and has for years been the standard bearer for resident house staff and attending anesthesiologists." ©Doody’s Review Service, 2025, Joshua E. Insler, MD (Yale School of Medicine)