Kanu ChatterjeeClinical Professor of Medicine, The Carver College of Medicine, University of Iowa, USA, Emeritus Professor of Medicine, University of California, San Francisco, USA Mark AndersonProfessor, Departments of Internal medicine and Molecular Physiology and Biophysics, Head, Department of Internal Medicine, Francois M Abboud Chair in Internal Medicine Donald HeistadProfessor of Medicine Richard E KerberProfessor of MedicineAll at The Carver College of Medicine, University of Iowa, USA