Male Infertility

Professor Thinus F. Kruger MD FRCOG - Reproductive Biology Unit, Department of Obstetrics & Gynaecology, Tygerberg Hospital, Tygerberg, South AfricaProfessor Sergio Oehninger - Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA, USA

• SECTION 1: BASIC CONCEPTS: SPERM PHYSIOLOGY AND PATHOLOGY1. Functional anatomy and molecular morphology of the spermatozoon2. Physiology and pathophysiology of sperm motility3. The pathophysiology and genetics of human male reproduction4. Contribution of the male gamete to fertilization and embryogenesis5. Genome architecture in human sperm cells: possible implications for male infertility and prediction of pregnancy outcome6. Sperm pathology: pathogenic mechanisms and fertility potential in assisted reproduction 7. Testicular dysgenesis syndrome (TDS): biological and clinical significanceSECTION 2: DIAGNOSIS OF MALE INFERTILITY 8. Evaluation of the subfertile male9. The basic semen analysis10. Advances in automated sperm morphology evaluation 11. Sperm morphology training and quality control programs are essential for clinically relevant results12. The role of the acrosome index in prediction of fertilization outcome13. Acrosome reaction: physiology and its value in clinical practice14. Sperm-zona pellucida binding assays15. Detection of DNA damage in sperm 16. Chromosomal and genetic abnormalities in male fertility17. Reactive oxygen species and its impact on fertility18. How do we define male subfertility and what is the prevalence in the general population?19. DNA fragmentation and its influence on fertilization and pregnancy outcome20. The impact of the paternal factor on embryo quality and development: the embryologist’s point of viewSECTION 3: THERAPEUTIC ALTERNATIVES FOR MALE INFERTILITY21. Clinical management of male infertility 22. Urological interventions for the treatment of male infertility23. Medical treatment of male infertility24. Male tract infections: diagnosis and treatment25. Sperm-washing techniques for the HIV-infected male: rationale and experience26. Treatment of HIV discordant couples – the Italian experience27. Artificial insemination using homologous and donor semen28. Intracytoplasmic sperm injection: current status of the technique and outcome 29. Sperm retrieval for intracytoplasmic sperm injection 30. Hyaluronic acid binding by human sperm: andrology evaluation of male fertility and sperm selection for intracytoplasmic sperm injection31. In-vitro maturation of spermatozoa 32. New developments in the evaluation and management of the infertile male

'This comprehensive book covers several aspects of male infertility very well and supports andrologists by providing information that is helpful in daily practice as well as additional information for the interested reader.' - Eugen Plas, Journal of Men's Health and Gender, June 2007 'This book is a cornerstone in literature focusing on male infertility ... The book delivers fascinating insights into clinically relevant current developments concerning male infertility.' - Andrologia (39 (2007) 74)