Ashok Agarwal, PhD, HCLD (ABB), ELD (ACE) is the Head of Andrology Center and Director of Research at the American Center for Reproductive Medicine since 1993. He holds these positions at The Cleveland Clinic Foundation, where he is Professor of Surgery (Urology) at the Lerner College of Medicine of Case Western Reserve University. Ashok was trained in Male Infertility and Andrology at the Brigham and Women's Hospital and Harvard Medical School and later worked as Assistant Professor of Urology at Harvard from 1988 to 1992. Ashok has over 28 years of experience in directing busy male infertility diagnostic facilities and fertility preservation services. He is very well published with over 735 scientific papers and reviews in peer-reviewed scientific journals and is ranked in Scopus as the #1 author in the world in the fields of Male Infertility/Andrology and Human Assisted Reproduction, based on the number of peer-reviewed publications, citation scores (Scopus: 32,432; Google Scholar: 69,225), and h-index (Scopus: 97; Google Scholar: 128). He is currently an editor of more than 40 medical text books/manuals related to male infertility, ART, fertility preservation, DNA damage, and antioxidants and active in basic and clinical research. His laboratory has trained over 1,000 scientists, clinicians, graduate, and undergraduate students from the United States and more than 55 countries. Ashok is the recipient of over 100 grants totaling over 15 million dollars. His current research interests include proteomics of male infertility and the molecular markers of oxidative stress and DNA integrity in the pathophysiology of male reproduction. Prof. Dr. Panagiotis Drakopoulos is Visiting Professor at the Centre for Reproductive Medicine (Universitair Ziekenhuis Brussel) in Belgium and Clinical & Scientific of the infertility clinic "I.R.I.S MED" in Herakion, Crete, Greece. He is recognized as a subspecialist in reproductive medicine and surgery by ESHRE (European Society of Human Reproduction and Embryology) and EBCOG (European Board & College of Obstetrics and Gynaecology). He has authored numerous articles in high indexed journals of the field, such as Fertility and Sterility and Human Reproduction. His research focuses on reproductive endocrinology as well as on poor ovarian responders and strategies to improve their outcome.

• SECTION 1 Definition, Epidemiology, and Implications of Male Infertility1. Definition, Epidemiology, and Implications of Male InfertilitySECTION 2 Causes of Male Infertility2. Pretesticular Causes of Male Infertility3. Testicular Causes of Male Infertility4. Posttesticular Causes of Male Infertility5. Environmental/Lifestyle Factors and Male Infertility6. Idiopathic Male InfertilitySECTION 3 Diagnosis of Male Infertility7. Medical History and Physical Examination of Infertile Males8. Basic Semen Analysis9. Sperm DNA Fragmentation Tests10. Genetic and Genomic Tests of Infertile Males11. Computer-Assisted Semen Analysis12. Seminal Oxidative Stress and Reactive Oxygen Species Testing13. Assessment of Reproductive Hormones in Infertile Males14. Imaging in Male Factor InfertilitySECTION 4 Medical Treatment of Male Infertility15. Hormonal Therapy of Male Infertility16. Antioxidants Therapy of Male Infertility17. Antibiotic Therapy of Male Infertility18. Alternative Therapy of Male InfertilitySECTION 5 Surgical Treatment of Male Infertility19. Varicocele Repair in Infertile Males20. Management of Ejaculatory Duct Obstruction21. Surgical Sperm Retrieval and Processing for Assisted Reproductive TechnologySECTION 6 Assisted Reproduction22. Intrauterine Insemination With Homologous Semen23. In Vitro Fertilization/Intracytoplasmic Sperm Injection24. Techniques for Selection of Surgically Retrieved Sperm for Intracytoplasmic Sperm Injection25. Sperm BankingSECTION 7 Clinical Practice Guidelines for Male Infertility26. Guidelines of the American Society for Reproductive Medicine, American Urological Association, and European Association of Urology27. Expert Opinion: Management of Male Infertility in the Postintracytoplasmic Sperm Injection EraSECTION 8 Insights Into the Future of Male Infertility28. Clinical Perspective in the Postintracyoplasmic Sperm Injection Era29. Research Perspectives in the Postintracytoplasmic Sperm Injection Era

Ashok Agarwal, PhD, HCLD (ABB), ELD (ACE) is the Head of Andrology Center and Director of Research at the American Center for Reproductive Medicine since 1993. He holds these positions at The Cleveland Clinic Foundation, where he is Professor of Surgery (Urology) at the Lerner College of Medicine of Case Western Reserve University. Ashok was trained in Male Infertility and Andrology at the Brigham and Women's Hospital and Harvard Medical School and later worked as Assistant Professor of Urology at Harvard from 1988 to 1992. Ashok has over 28 years of experience in directing busy male infertility diagnostic facilities and fertility preservation services. He is very well published with over 735 scientific papers and reviews in peer-reviewed scientific journals and is ranked in Scopus as the #1 author in the world in the fields of Male Infertility/Andrology and Human Assisted Reproduction, based on the number of peer-reviewed publications, citation scores (Scopus: 32,432; Google Scholar: 69,225), and h-index (Scopus: 97; Google Scholar: 128). He is currently an editor of more than 40 medical text books/manuals related to male infertility, ART, fertility preservation, DNA damage, and antioxidants and active in basic and clinical research. His laboratory has trained over 1,000 scientists, clinicians, graduate, and undergraduate students from the United States and more than 55 countries. Ashok is the recipient of over 100 grants totaling over 15 million dollars. His current research interests include proteomics of male infertility and the molecular markers of oxidative stress and DNA integrity in the pathophysiology of male reproduction. Prof. Dr. Panagiotis Drakopoulos is Visiting Professor at the Centre for Reproductive Medicine (Universitair Ziekenhuis Brussel) in Belgium and Clinical & Scientific of the infertility clinic "I.R.I.S MED" in Herakion, Crete, Greece. He is recognized as a subspecialist in reproductive medicine and surgery by ESHRE (European Society of Human Reproduction and Embryology) and EBCOG (European Board & College of Obstetrics and Gynaecology). He has authored numerous articles in high indexed journals of the field, such as Fertility and Sterility and Human Reproduction. His research focuses on reproductive endocrinology as well as on poor ovarian responders and strategies to improve their outcome.

• SECTION 1 Definition, Epidemiology, and Implications of Male Infertility1. Definition, Epidemiology, and Implications of Male InfertilitySECTION 2 Causes of Male Infertility2. Pretesticular Causes of Male Infertility3. Testicular Causes of Male Infertility4. Posttesticular Causes of Male Infertility5. Environmental/Lifestyle Factors and Male Infertility6. Idiopathic Male InfertilitySECTION 3 Diagnosis of Male Infertility7. Medical History and Physical Examination of Infertile Males8. Basic Semen Analysis9. Sperm DNA Fragmentation Tests10. Genetic and Genomic Tests of Infertile Males11. Computer-Assisted Semen Analysis12. Seminal Oxidative Stress and Reactive Oxygen Species Testing13. Assessment of Reproductive Hormones in Infertile Males14. Imaging in Male Factor InfertilitySECTION 4 Medical Treatment of Male Infertility15. Hormonal Therapy of Male Infertility16. Antioxidants Therapy of Male Infertility17. Antibiotic Therapy of Male Infertility18. Alternative Therapy of Male InfertilitySECTION 5 Surgical Treatment of Male Infertility19. Varicocele Repair in Infertile Males20. Management of Ejaculatory Duct Obstruction21. Surgical Sperm Retrieval and Processing for Assisted Reproductive TechnologySECTION 6 Assisted Reproduction22. Intrauterine Insemination With Homologous Semen23. In Vitro Fertilization/Intracytoplasmic Sperm Injection24. Techniques for Selection of Surgically Retrieved Sperm for Intracytoplasmic Sperm Injection25. Sperm BankingSECTION 7 Clinical Practice Guidelines for Male Infertility26. Guidelines of the American Society for Reproductive Medicine, American Urological Association, and European Association of Urology27. Expert Opinion: Management of Male Infertility in the Postintracytoplasmic Sperm Injection EraSECTION 8 Insights Into the Future of Male Infertility28. Clinical Perspective in the Postintracyoplasmic Sperm Injection Era29. Research Perspectives in the Postintracytoplasmic Sperm Injection Era

Ashok Agarwal, PhD, HCLD (ABB), ELD (ACE) is the Head of Andrology Center and Director of Research at the American Center for Reproductive Medicine since 1993. He holds these positions at The Cleveland Clinic Foundation, where he is Professor of Surgery (Urology) at the Lerner College of Medicine of Case Western Reserve University. Ashok was trained in Male Infertility and Andrology at the Brigham and Women's Hospital and Harvard Medical School and later worked as Assistant Professor of Urology at Harvard from 1988 to 1992. Ashok has over 28 years of experience in directing busy male infertility diagnostic facilities and fertility preservation services. He is very well published with over 735 scientific papers and reviews in peer-reviewed scientific journals and is ranked in Scopus as the #1 author in the world in the fields of Male Infertility/Andrology and Human Assisted Reproduction, based on the number of peer-reviewed publications, citation scores (Scopus: 32,432; Google Scholar: 69,225), and h-index (Scopus: 97; Google Scholar: 128). He is currently an editor of more than 40 medical text books/manuals related to male infertility, ART, fertility preservation, DNA damage, and antioxidants and active in basic and clinical research. His laboratory has trained over 1,000 scientists, clinicians, graduate, and undergraduate students from the United States and more than 55 countries. Ashok is the recipient of over 100 grants totaling over 15 million dollars. His current research interests include proteomics of male infertility and the molecular markers of oxidative stress and DNA integrity in the pathophysiology of male reproduction. Prof. Dr. Panagiotis Drakopoulos is Visiting Professor at the Centre for Reproductive Medicine (Universitair Ziekenhuis Brussel) in Belgium and Clinical & Scientific of the infertility clinic "I.R.I.S MED" in Herakion, Crete, Greece. He is recognized as a subspecialist in reproductive medicine and surgery by ESHRE (European Society of Human Reproduction and Embryology) and EBCOG (European Board & College of Obstetrics and Gynaecology). He has authored numerous articles in high indexed journals of the field, such as Fertility and Sterility and Human Reproduction. His research focuses on reproductive endocrinology as well as on poor ovarian responders and strategies to improve their outcome.

• SECTION 1 Definition, Epidemiology, and Implications of Male Infertility1. Definition, Epidemiology, and Implications of Male InfertilitySECTION 2 Causes of Male Infertility2. Pretesticular Causes of Male Infertility3. Testicular Causes of Male Infertility4. Posttesticular Causes of Male Infertility5. Environmental/Lifestyle Factors and Male Infertility6. Idiopathic Male InfertilitySECTION 3 Diagnosis of Male Infertility7. Medical History and Physical Examination of Infertile Males8. Basic Semen Analysis9. Sperm DNA Fragmentation Tests10. Genetic and Genomic Tests of Infertile Males11. Computer-Assisted Semen Analysis12. Seminal Oxidative Stress and Reactive Oxygen Species Testing13. Assessment of Reproductive Hormones in Infertile Males14. Imaging in Male Factor InfertilitySECTION 4 Medical Treatment of Male Infertility15. Hormonal Therapy of Male Infertility16. Antioxidants Therapy of Male Infertility17. Antibiotic Therapy of Male Infertility18. Alternative Therapy of Male InfertilitySECTION 5 Surgical Treatment of Male Infertility19. Varicocele Repair in Infertile Males20. Management of Ejaculatory Duct Obstruction21. Surgical Sperm Retrieval and Processing for Assisted Reproductive TechnologySECTION 6 Assisted Reproduction22. Intrauterine Insemination With Homologous Semen23. In Vitro Fertilization/Intracytoplasmic Sperm Injection24. Techniques for Selection of Surgically Retrieved Sperm for Intracytoplasmic Sperm Injection25. Sperm BankingSECTION 7 Clinical Practice Guidelines for Male Infertility26. Guidelines of the American Society for Reproductive Medicine, American Urological Association, and European Association of Urology27. Expert Opinion: Management of Male Infertility in the Postintracytoplasmic Sperm Injection EraSECTION 8 Insights Into the Future of Male Infertility28. Clinical Perspective in the Postintracyoplasmic Sperm Injection Era29. Research Perspectives in the Postintracytoplasmic Sperm Injection Era