Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction

• I. Ionic Determinants of Electrical Activity.- 1. Calcium current and excitation-contraction coupling in heart..- 2. Role of cytosolic calcium in the normal and ischemic heart: potential new insights from the second generation indicator, Indo-1..- 3. Repetitive activity: origin of the Na+ load and its physiologic effects..- 4. Ionic changes associated with acute ischemia..- 5. Mechanisms of reperfusion arrhythmias..- II. Metabolic Factors in Ischemia.- 6. Ischemia and Na+/K+ pump function..- 7. Amphipathic lipid metabolites and arrhythmogenesis: a perspective..- 8. Free radicals and myocardial injury during ischemia and reperfusion: a short-lived phenomenon?.- 9. Thyroid hormones and cardiac function..- III. Neural and Hormonal Factors.- 10. Receptor mechanisms in ischemia and infarction..- 11. Sympathetic-parasympathetic interactions in the normal heart..- 12. Central nervous system modulation of cardiac rhythm..- 13. Influence of ischemia and infarction on cardiac vagal and sympathetic innervation..- IV. Arrhythmogenic Nechanisms.- 14. On the problem of anisotropic propagation in ventricular muscle..- 15. Anisotropic reentry: A model of arrhythmias that may necessitate a new approach to antiarrhythmic drug development..- 16. Arrhythmias in the early ischemic period..- 17. Arrhythmias and the healed myocardial infarction..- V. Strategies for Prediction, Prevention and Therapy.- 18. Clinical significance and limitations of ventricular late potentials..- 19. Pacing to predict mechanism: transient entrainment and reentry..- 20. The value of programmed electrical stimulation in triggered activity-induced arrhythmias..- 21. Pharmacologic mechanisms in the treatment of arrhythmias due to ischemia and infarction..- 22. Cardiac innervation and sudden death: new strategies forprevention..

'This book will provide the cardiologist valuable information on the various mechanisms of lethal arrhythmias arising from myocardial ischemia and infarction.' Acta Cardiologica, Vol. XLIV, 1989, p. 439