Lethal Arrhythmias Resulting from Myocardial Ischemia and Infarction

• I. Ionic Determinants of Electrical Activity.- 1. Calcium current and excitation-contraction coupling in heart..- 2. Role of cytosolic calcium in the normal and ischemic heart: potential new insights from the second generation indicator, Indo-1..- 3. Repetitive activity: origin of the Na+ load and its physiologic effects..- 4. Ionic changes associated with acute ischemia..- 5. Mechanisms of reperfusion arrhythmias..- II. Metabolic Factors in Ischemia.- 6. Ischemia and Na+/K+ pump function..- 7. Amphipathic lipid metabolites and arrhythmogenesis: a perspective..- 8. Free radicals and myocardial injury during ischemia and reperfusion: a short-lived phenomenon?.- 9. Thyroid hormones and cardiac function..- III. Neural and Hormonal Factors.- 10. Receptor mechanisms in ischemia and infarction..- 11. Sympathetic-parasympathetic interactions in the normal heart..- 12. Central nervous system modulation of cardiac rhythm..- 13. Influence of ischemia and infarction on cardiac vagal and sympathetic innervation..- IV. Arrhythmogenic Nechanisms.- 14. On the problem of anisotropic propagation in ventricular muscle..- 15. Anisotropic reentry: A model of arrhythmias that may necessitate a new approach to antiarrhythmic drug development..- 16. Arrhythmias in the early ischemic period..- 17. Arrhythmias and the healed myocardial infarction..- V. Strategies for Prediction, Prevention and Therapy.- 18. Clinical significance and limitations of ventricular late potentials..- 19. Pacing to predict mechanism: transient entrainment and reentry..- 20. The value of programmed electrical stimulation in triggered activity-induced arrhythmias..- 21. Pharmacologic mechanisms in the treatment of arrhythmias due to ischemia and infarction..- 22. Cardiac innervation and sudden death: new strategies forprevention..

`This book will provide the cardiologist valuable information on the various mechanisms of lethal arrhythmias arising from myocardial ischemia and infarction.'Acta Cardiologica, Vol. XLIV, 1989, p. 439