Ketogenic Diet and Metabolic Therapies

Susan A. Masino is the Vernon Roosa Professor of Applied Science and Professor of Psychology and Neuroscience at Trinity College. Her research is focused on adenosine, an endogenous molecule that promotes homeostasis and links between metabolism and brain activity. In 2008 she proposed that adenosine is a key mechanism underlying ketogenic diet therapy; based on this, her research spans multiple conditions. Dr. Masino is also dedicated to educational, environmental and public policy issues affecting brain health.

• Table of ContentsPreface Contributors List Section I Ketogenic Diet for Epilepsy in the Clinic Eric Kossoff, MD, Section Editor Chapter 1 Overview- Ketogenic Diets and Pediatric Epilepsy: An UpdateEric Kossoff, MD Chapter 2 'Alternative' Ketogenic DietsElizabeth Neal, RD, MSc, PhDChapter 3 Dietary Therapy in Adults: History, Demand, and ResultsEmily L. Johnson, MD and Mackenzie C. Cervenka, MDChapter 4 How Do You Implement the Diet? Christina Bergqvist, MDChapter 5 Glut1 Deficiency and the KD Joerg Klepper, MD, PhDChapter 6 Ketogenic Diet in Established Epilepsy IndicationsAnn Bergin, MD, MB, ScM, MRCPChapter 7 Ketogenic Diet for Other EpilepsiesDavid T. Hsieh, MD and Elizabeth A. Thiele, MD, PhDChapter 8 The Ketogenic Diet and Related Therapies in "Novel" Situations: Idiopathic Generalized Epilepsy SyndromesSudha Kilaru Kessler MD, MSCEChapter 9 Ketogenic Diet in Status EpilepticusRima Nabbout, MD, PhDChapter 10 Preventing Side Effects and Diet DiscontinuationCherie L. Herren, MD and Rana R. Said, MD Section II Ketogenic Diet - Emerging Clinical Applications and Future Potential Jong M. Rho, MD, Section Editor Chapter 11 Overview: Expanded Uses of Ketogenic Therapies Jong M. Rho, MD Chapter 12 Metabolism-Based Treatments to Counter Cancer: Scientific Rationale Thomas N. Seyfried, PhD and Laura Shelton, PhD Chapter 13 Ketogenic Diet as Adjunctive Therapy for Malignant Brain CancerEric C. Woolf, PhD and Adrienne C. Scheck, PhD Chapter 14 Metabolic Therapy for Autism Spectrum Disorder and Co-MorbiditiesNing Cheng, PhD, Susan A. Masino, PhD, and Jong M. Rho, MDChapter 15 Glucose and Ketone Metabolism in the Aging Brain: Implications for Therapeutic Strategies to Delay the Progression of Alzheimer's DiseaseStephen C. Cunnane, PhD, Alexandre Courchesne-Loyer, MSc, Valerie St-Pierre, BSc, Camille Vandenberghe, PhD, Etienne Croteau, PhD, and Christian-Alexandre Castellano, PhDChapter 16 Ketogenic Diet and Ketones for the Treatment of Traumatic Brain and Spinal Cord InjuryFemke Streijger, PhD, Ward T. Plunet, PhD, and Wolfram Tetzlaff, MD, Dr.Med, PhDChapter 17 Anti-Inflammatory Effects of a Ketogenic Diet: Implications for New IndicationsNina Dupuis, PhD and Stéphane Auvin, MD, PhDChapter 18 Dietary Therapy for Neurological Disorders: Focus on Amyotrophic Lateral Sclerosis, Parkinson's Disease, Mood Disorders, and MigraineCarl E. Stafstrom, MD, PhD Section III Ketogenic Diet in the Laboratory Detlev Boison, PhD Section Editor Chapter 19 Overview of Ketogenic Diet in the Laboratory: Progress on Models and MechanismsDetlev Boison PhDChapter 20 Ketogenic Diet and PPARgTimothy A. Simeone, PhDChapter 21 Ketogenic Diet in a Hippocampal Slice: Models and MechanismsMasahito Kawamura, Jr, PhDChapter 22 Metabolic Therapy and PainDavid N. Ruskin, PhDChapter 23 Ketogenic Diet, Adenosine, Epigenetics, and AntiepileptogenesisTheresa A. Lusardi, PhD and Detlev Boison, PhDChapter 24 Ketogenic Diet, Aging, and NeurodegenerationKui Xu, MD, PhD, Joseph C. LaManna, PhD and Michelle A. Puchowicz, PhDChapter 25 Endocrine and Reproductive Effects of Ketogenic DietsJacob P. Harney, PhD, Kathryn Gudsnuk, MS, Ami Patel, MD Anantha R. Vellipuram, MD, Sathyajit Bandaru, MS and David Butler, PhDChapter 26 Alzheimer's Disease: Causes and TreatmentRichard L. Veech, MD, PhD, DPhil and M. Todd KingChapter 27 Mitigation of Damage from Reactive Oxygen Species and Ionizing Radiation by Ketone Body Esters William Curtis, Martin Kemper, PhD, Alexandra Miller, PhD, Robert Pawlosky, PhD, M. Todd King, and Richard L. Veech, MD, PhD, DPhilChapter 28 Metabolic Seizure Resistance via BAD and KATP ChannelsJuan Ramón Martínez-François, PhD, Nika Danial, PhD, and Gary Yellen, PhDChapter 29 Lactate Dehydrogenase: A Novel Metabolic TargetNagisa Sada, PhD and Tsuyoshi Inoue, PhDChapter 30 Effects of the Ketogenic Diet on the Blood-Brain BarrierManoj Banjara, PhD and Damir Janigro, PhD Section IV Ketone-Based Metabolism: General Health and Metabolic Alternatives Dominic P. D'Agostino, PhD Section Editor Chapter 31 Overview of Ketone-Based Metabolism: General Health and Metabolic AlternativesDominic P. D'Agostino, PhDChapter 32 Ketone Supplementation for Health and DiseaseAngela M. Poff, PhD, Shannon L. Kesl, PhD, and Dominic P. D'Agostino, PhDChapter 33 Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet Matthew C. Walker, PhD and Robin S.B. Williams, PhDChapter 34 Triheptanoin in Epilepsy and Beyond Karin Borges, PhD Chapter 35 Amino Acids in the Treatment of Neurological DisordersAdam L. Hartman, MDChapter 36 2-Deoxyglucose: Metabolic Control of Seizures through Inhibition of Glycolysis Carl E. Stafstrom, MD, PhD and Thomas P. Sutula, MD, PhD Chapter 37 Ketogenic Diets as Highly Effective Treatments for Diabetes Mellitus and ObesityEric C. Westman, MD, MHS, Emily Maguire, MSc, and William S. Yancy Jr., MD, MHS Chapter 38 Keto-Adaptation in Health and FitnessParker Hyde, CSCS, CISSN, Vincent J. Miller, PhD, and Jeff S. Volek, PhD, RDChapter 39 Advancing the Awareness and Application of Ketogenic Therapies Globally: The Charlie Foundation and Matthew's FriendsBeth Zupec-Kania, RD, CD, Jim Abrahams, Emma Williams, MBE, Susan A. Masino, PhD