Innate Immune System of Skin and Oral Mucosa

Nava Dayan PhD, is the R&D Director at Lipo Chemicals Inc. and an Associate Adjunct Professor in the Ernest Mario School of Pharmacy at Rutgers University. During her twenty four years of experience she has specialized in a variety of areas related to skin treatment, especially in the research and understanding of the interaction between topically applied compounds and the skin. Dr. Dayan has received numerous awards for excellence for various papers she has authored. She is the author and coauthor of more than a hundred and fifty publications, including book chapters, and has been granted eight patents. She is also the editor of three books, including Formulating, Packaging, and Marketing of Natural Cosmetic Products (Wiley). Philip W. Wertz PhD, is a Professor in the Department of Oral Pathology, Radiology, and Medicine at the University of Iowa College of Dentistry and in The Dows Institute for Dental Research. He is currently on the Editorial Advisory Board of the International Journal of Cosmetic Science and the Editorial Board of the TransDermal and Journal of Lipids.

• Preface ix Contributors xiPart I Overview of Skin and Muscosal Innate Immunity: History, Ethics, and ScienceChapter 1 Germ Free: Hygiene History and Consuming Antimicrobial and Antiseptic Products 3Jennifer Tebbe-Grossman and Martha N. GardnerChapter 2 Ethical Responsibilities in Formulating, Marketing, and Using Antimicrobial Personal Products 43Kenneth A. RichmanChapter 3 Role of Stratum Corneum in Permeability Barrier Function and Antimicrobial Defense 59Peter M. EliasPart II Antimicrobial Lipids and PeptidesChapter 4 Antimicrobial Lipids of the Skin and Oral Mucosa 75Kim A. Brogden, David R. Drake, Deborah V. Dawson, Jennifer R. Hill, Carol L. Bratt, and Philip W. WertzChapter 5 Resident Microflora and Antimicrobial Peptides of Skin 83Shamim A. AnsariChapter 6 Defensins 109Neelam MuizzudinChapter 7 Antimicrobial Peptides of Skin and Oral Mucosa 117Whasun O. Chung and Henrik DommischChapter 8 Vernix Caseosa and Innate Immunity 145Steven B. Hoath, Vivek Narendran, and Marty O. VisscherPart III Host Cellular Components of Innate ImmunityChapter 9 Sentinel Role of Mast Cells in Innate Immunity 173Zhenping Wang and Anna Di NardoChapter 10 Cellular Immunity of the Skin: Langerhans Cells and Dendritic Cells 195Karen E. Burke and Niroshana AnandasabapathyPart IV Innate Immunity Response to Stress and AgingChapter 11 Changes in Skin Immunity with Age and Disease 217Barbara Geusens, Iles Mollet, Chris D. Anderson, Sarah Terras, Michael S. Roberts, and Jo LambertChapter 12 Epidermis as a Sheild from Radiation and Oxidative Stress 259Giuseppe ValacchiChapter 13 The Impact of the Skin’s Innate Immunity by Cosmetic Products Applied to the Skin and Scalp 275Rudranath Persaud and Thomas ReChapter 14 UV-Induced Immunosuppression of Skin 281Roger L. McMullenPart V Innate Immunity Microbial ChallengesChapter 15 Deranged Antimicrobial Barrier in Atopic Dermatitis: Roles of Sphingosine, Hexadecenoic Acid, and Beta-Defensine-2 307Gangi ImokawaChapter 16 Resident Microflora of the Skin and Oral Mucosa 325David R. DrakeChapter 17 Corynebacterium Species and Their Role in the Generation of Human Malodor 333Carol L. Bratt and Nava DayanIndex 351

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