Industrial Guide to Chemical and Drug Safety

Turuvekere Subrahmanya Shanmukha DIKSHITH, PhD, was the head of The Pesticide Toxicology Division, Industrial Toxicology Research Centre, (CSIR), Lucknow, and later director of the Toxicology Research Laboratory, VIMTA Labs Ltd., Hyderabad, India. He is presently the Consultant, Pharmacology Division, Indian Institute for Chemical Technology (CSIR), Hyderabad, India. He is a member of the World Health Organization Task Group on Environmental Health Criteria Documents and the International Program on Chemical Safety. He is also the editor of Toxicology of Pesticides in Animals, and author of Safety Evaluation of Environmental Chemicals. PRAKASH V. DIWAN, PhD, is the Deputy Director, Pharmacology Division, Indian Institute of Chemical Technology (CSIR), Hyderabad, India. He has been elected as a Fellow of the Andhra Pradesh Academy of Sciences.

• Foreword xxiiiPreface xxvAcknowledgments xxviiChapter 1 Introduction to Chemical and Drug Safety 1Chapter 2 Principles of Toxicity and Safety 19Chapter 3 Heavy Metals 59Chapter 4 Organochlorine Pesticides 89Chapter 5 Organophosphorus Pesticides 123Chapter 6 Herbicides and Fungicides 157Chapter 7 Carbamates 184Chapter 8 Synthetic Pyrethroids, Fumigants, and Rodenticides 198Chapter 9 Industrial Solvents 207Chapter 10 Food Additives and Food Contaminants 242Chapter 11 Industrial Gases and Fumes 252Chapter 12 Drugs: Discovery and Development 259Chapter 13 Drugs and Human Diseases 275Chapter 14 Nonmedical Use of Drugs 320Chapter 15 Drugs and Pharmaceuticals: Safety Considerations 332Chapter 16 Target Organ Toxicity 377Chapter 17 Disposal of Hazardous Chemicals 408Chapter 18 Good Laboratory Practice 429Chapter 19 Safety Evaluation: Methods and Procedures 465Chapter 20 Guidance for Laboratory Students and Occupational Workers 504Appendixes 521Glossary 597Index 617

"…a readable textbook with extensive breath and adequate depth. Readers can use this text to obtain a broad foundation or to use as a quick reference…” (Veterinary Pathology, September 2004) "...concise and clear...written in an accessible narrative style...offers valuable information to the target audience..." (The British Toxicological Society, No. 24, Summer 2004)“...this book is just the right size for anyone’s bookshelf...a great textbook or resource text...” (Chemical Health & Safety, November/December 2003)"What a volume of information!...a must for beginning graduate students, enthusiastic workers...and even as a reference for experienced colleagues in toxicology." (Veterinary and Human Toxicology, Vol. 45, No. 4, August 2003)"This comprehensive work contains a vast amount of information... it is intended for laboratory personnel involved in the manufacture of chemicals, but it contains information that will be useful for anyone who handles or is exposed to chemicals or who is interested in action and effects of chemical substances.... Essential." (Choice, Vol. 41, No. 3, November 2003)"...offers the reader a good first introduction to this extensive and complex area." (Angewandte Chemie, International Edition, Vol. 42(24), 2003)